Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen; or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl; R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3, alkyl, C1-3, haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.

Abstract: A method, an apparatus, and a non-transitory computer readable medium for parking assistance are provided. The method includes identifying a parking space based on information acquired from a plurality of sensors, connecting to a sensor associated with the identified parking space, acquiring measurement data from the sensor indicative of a vehicle position relative to the sensor, determining a parking trajectory based on the measurement data, and controlling at least a subsystem of a vehicle based on the parking trajectory.

Abstract: As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).

Abstract: An augmented reality (AR) device including at least one optical module is provided. Each of the at least one optical module sequentially includes a transparent display, a first lens, a second lens, and a third lens from a display side to an eye side. The first lens has a negative refractive power. The second lens has a negative refractive power. The third lens has a positive refractive power. The number of lenses of the optical module having refractive powers is three, wherein the transparent display of the optical module is configured to emit a light beam, and the light beam sequentially passes through the first lens, the second lens, and the third lens to be incident into a user's eyes at the eye side, so that an AR virtual image on the display side is seen by the eyes.

Abstract: Encapsulating cover for an electronic package is formed by a cover body having a front wall and, positioned around a through-passage, a mounting face that includes a bearing surface. A mounting face of an optical element bears against the bearing surface. The mounting face includes at least one local void that is set back with respect to the bearing surface to provide a space between the mounting face of the optical element and the bottom of the local void. The local void extends beyond an edge of the optical element. A drop of fastening adhesive extends locally into said local void and has a portion that is covered by the optical element and an uncovered portion that is located beyond the edge of the optical element.

Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.

Abstract: According to an aspect of the present invention, there is provided a light radiating probe which is flexible and uniformly radiates light emitted from a light scattering and radiating portion at all azimuth angles of 360° so as to enable the simultaneous radiation of light to cancers disposed at a plurality of places scattered in a wide region. The light radiating probe for photodynamic therapy according to the present invention includes an optical fiber which extends in an axial direction and through which light from a light source propagates, in which the optical fiber has a light guide portion which is formed by forming thin film cladding on a side surface of a flexible core, and a light scattering and radiating portion which is configured to scatter, with uniform intensity, light propagating through the light guide portion to a periphery of the light scattering and radiating portion in all azimuth angles with respect to an axial direction of the flexible core.

Abstract: A channel control method and apparatus for improving the transmission capacity of packet data and communications reliability in V2X vehicle packet communications. In V2X wireless communications, the number and bandwidths of transmission channels are predetermined. The control method monitors signal levels received between transceivers and the frequency of channel usage, and based on the result. of the monitoring, varies at least one of the bandwidth of frequency channels and the number of transmission channels. The control method is adaptive to wireless channels. The bandwidth of a transmission channel is variably assigned to, depending on whether the channel status for signal reception is good or bad. The number of transmission channels is variably assigned to, depending on whether the usage frequency of a reception channel is low or high.

Abstract: A semiconductor circuit including a clocked comparator and an offset application circuit. The clocked comparator is configured to receive a first input signal and a second input signal from a host and compare the first input signal and the second input signal. The offset application circuit is configured to apply an offset to the first input signal. The clocked comparator is configured to be driven based on a reference clock provided from the host.

Abstract: A method for fabricating metal decorations on a domed dial made of insulating material, wherein the method includes the steps of forming a photosensitive resin mould by a UV LIGA type process, and electrodepositing a layer of at least one metal starting from the conductive layer to form a block, which substantially reaches the upper surface of the photosensitive resin.

Abstract: The present invention relates to a flexible electrode and a method for manufacturing the same. According to an embodiment of the present invention, the flexible electrode includes a substrate 10, a bonding layer 20 formed by adsorbing an amino group (NH2)-containing monomolecular material on the substrate 10, and a conductive layer 30 formed by coating metal nanoparticles 31 on the bonding layer 20.

Abstract: This document relates to methods and materials involved in detecting gene amplification in a mammal. For example, methods and materials for detecting amplification at CPM and MDM2 loci to determine the presence or absence of a malignant lipomatous neoplasm in a mammal are provided.

Abstract: A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

Abstract: Disclosed is a method of printing a CNT 3D structure. The present invention provides a method of manufacturing a CNT composite material structure, the method including: providing ink, in which a carbon nanotube (CNT) composite material including a CNT and a rheological modifier is dispersed, to a nozzle; positioning the nozzle at a predetermined point on a substrate; and moving the nozzle along a predetermined path on the substrate while discharging the ink from the nozzle and printing a CNT composite material pattern corresponding to a movement path of the nozzle, in which in the printing of the CNT composite material pattern, the pattern is stacked as the CNT composite material by evaporation of a solvent within a meniscus formed by the ink extruded from the nozzle between the nozzle and the substrate.

Abstract: A tunable electro-optic modulation (EOM) comb generator includes a frequency locking optoelectronic oscillator (OEO) loop including RF electrical components including a phase shifter (PS1), a splitter, and optical components including an intensity modulator (IM) coupled to receive light from a light source and to couple modulated light generated to a frequency locking loop including a frequency shifter, a first phase modulator (PM1), and a periodic optical filter (POF), such as an etalon or resonator. The POF is for optically filtering the OEO loop to generate an optical output and the splitter is for generating RF electrical outputs including at least one RF output coupled to an input of the IM and another RF output coupled to an EO comb including at least a phase modulator. The EO comb combines the optical output and the another RF output to generate a broadband optical frequency comb output.

Abstract: The present application provides flexible radio frequency (RF) assemblies, components thereof and related methods. The present application includes at least one flexible substrate comprising first and second sides, a flexible framework portion comprising a first material composition and a plurality of discrete spaced interior portions comprising second material compositions that differ from that of the flexible framework portion. The framework portion extends fully about a portion of each interior portion. The framework portion comprises a flexibility that is greater than that of the interior portions. Each interior portion and the framework portion comprise a dielectric constant, a loss tangent, a volume resistivity, a surface resistivity and a magnetic relative permeability. At least one of the dielectric constant, the loss tangent, the volume resistivity, the surface resistivity and the magnetic relative permeability of at least one of the interior portions differs from that of the framework portion.

Abstract: Provided are methods, kits and compositions related to toxicity associated with administration of cell therapy for the treatment of diseases or conditions, e.g., cancer, including methods for use in predicting and treating a toxicity. In some embodiments, the toxicity is a neurotoxicity or cytokine release syndrome (CRS), such as a severe neurotoxicity or a severe CRS. The methods generally involve detecting a parameter of a biomarker or individually a parameter of each biomarker in a panel of biomarkers, such as a concentration, amount or activity, and comparing the detected parameter to a reference value for the parameter to determine if the subject is at risk for developing the toxicity, such as neurotoxicity or CRS or severe neurotoxicity or severe CRS.

Abstract: Disclosed is a method for focusing light to a target object within scattering medium comprising the following steps: (a) illuminating a plurality of incidence beams having different incidence patterns from each other, and obtaining reflection beams which are reflected from the target object for each incidence beams by a flight time which is a arrival time of the reflection beam to a camera; (b) forming a time-gated reflection matrix using the plurality of the incidence beams and the plurality of the reflection beams; (c) applying the time-gated reflection matrix to Single Value Decomposition such that a time-gated eigenchannel corresponding to a depth of the target object is calculated; (d) illuminating an eigen incidence beam having an incidence pattern, to which the time-gated eigenchannel is applied, to the target object.

Abstract: In the present invention, by providing a device for determining a state of an optical network terminal line including: an optical signal transfer interface configured to transfer a downlink signal transmitted from an optical line terminal to an optical network terminal line and to transfer an uplink signal transmitted from an optical network terminal connected to the optical network terminal line to the optical line terminal; an optical signal transmitter configured to transmit an optical signal to the optical signal transfer interface; an optical signal receiver configured to receive the downlink signal through the optical signal transfer interface, to receive a reflected signal corresponding to the optical signal, and to detect intensity of the downlink signal and the reflected signal; a signal converter configured to convert the reflected signal from an analog form to a digital form; a signal processor configured to analyze the reflected signal of a digital form and to determine the state of the optical ne