Abstract: The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where R1 and R2 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts.

Abstract: Provided is a defoaming agent for a liquid detergent, comprising the following components: component A1, a modified polyorganosiloxane formed by reacting a hydrogen-containing polyorganosiloxane, an unsaturated polyether and an ?-olefin; component A2, a modified polyorganosiloxane formed by reacting a hydrogen-containing polyorganosiloxane, an unsaturated polyether and a bivinyl-terminated polyorganosiloxane; component B, an organosilicon composition composed of a hydrogen-containing polyorganosiloxane, a polymer composed of an acrylate and an ?-olefin, silica and an organosilicon resin; component C, a thickening agent; and component D, water. An excellent compatibility between the modified polyorganosiloxanes A1 and A2 enables the defoaming agent to exhibit an excellent defoaming performance, stability and clarity in a laundry detergent.

Abstract: Various nanostructures, including silicon nanowires and encapsulated silicon nanoislands, and methods of making the nanostructures are provided. The methods can include providing a fin structure extending above a substrate, wherein the fin structure has at least one silicon layer and at least two silicon:germanium alloy (SiGe) layers that define sidewalls of the fin structure; and annealing the fin structure in oxygen to form a silicon nanowire assembly. The silicon nanowire assembly can include a silicon nanowire, a SiGe matrix surrounding the silicon nanowire; and a silicon oxide layer disposed on the SiGe matrix. The annealing can be, for example, at a temperature between 800° C. and 1000° C. for five minutes to sixty minutes. The silicon nanowire can have a long axis extending along the fin axis, with perpendicular first and second dimensions extending less than 50 nm along directions perpendicular to the fin axis.

Abstract: A sound source separation apparatus includes: a separation-matrix processor that transforms a plurality of observation signals corresponding to sounds being propagated from a plurality of sound sources into a frequency-domain signal group the separation-matrix processor updating a separation matrix based on the frequency-domain signal group and transforming the updated separation matrix into time-series filter coefficients to output; a filter-coefficient transformer that partially removes non-causal components from the filter coefficients to transform the filter coefficients, and a separator that supplies the filter coefficients to a filter group, the separator generating a plurality of separation signals separated from the plurality of observation signals corresponding to the separation matrix.

Abstract: Provided are a method for manufacturing a light emitting apparatus, the light emitting apparatus, and a window. The method for manufacturing the light emitting apparatus includes preparing a liquid crystal device including a support substrate, a first electrode, a liquid crystal layer, and a sacrificial structure, separating the sacrificial structure from the liquid crystal layer to expose one surface of the liquid crystal layer, and forming a second electrode on the one surface of the liquid crystal layer.

Abstract: The present disclosure relates to a metal-containing graphene hybrid composite, a preparing method of the metal-containing graphene hybrid composite, and a preparing method of a metal-containing graphene hybrid film.

Abstract: A metal-air battery includes an anode and a passivation layer formed on the anode. The passivation layer functions as electrolyte and cathode, so that no additional electrolyte or cathode is included. During discharge, metal cations derived from oxidation of the anode migrate across the passivation layer, and react with nucleophilic gas and electrons received from a gas diffusion layer. The metal-air battery, by virtue of having no added electrolyte or cathode, is compact and contains no volatile materials.

Abstract: The present invention provides a radiation detector comprising: a scintillator for absorbing radiation to generate light; and a light detector formed in the scintillator, wherein the scintillator is composed of a two-dimensional nanomaterial for imparting ductility. The scintillator is formed by laminating the two-dimensional nanomaterial, the two-dimensional nanomaterial being at least one of graphene oxide, reduced graphene oxide, and graphene quantum dots.

Abstract: System, methods, and other embodiments described herein relate to locating an object within an image and projecting the object into a map. In one embodiment, a method includes, responsive to identifying a nearby vehicle in an image of an external environment surrounding a scanning vehicle, determining a relative location of the nearby vehicle in relation to the scanning vehicle using the image. The method includes projecting the nearby vehicle into a map according to at least the relative location determined from the image. The method includes controlling the scanning vehicle according to the map.

Abstract: An environment recognition system using vehicular millimeter wave radar includes a millimeter wave radar device detecting obstructions outside a vehicle and transforming detection results into reflection information. An energy intensity calculation device, an anti-noise calculation device, and an obstruction width calculation device are signally connected with the millimeter wave radar device to receive the reflection information, respectively calculate energy intensity information, signal-to-noise ratios and width information of the obstructions and transmit them to a control device. The control device integrates the energy intensity information, the signal-to-noise ratios and the width information to recognize types of the obstructions. The present invention can effectively recognize various obstructions outside the vehicle whereby the vehicle immediately reacts like performing a corresponding safety anti-collision system when detecting pedestrians.

Abstract: Motion of multiple agents with identical non-linear dynamics is controlled to change density of the agents from the initial to the final density. A first control problem is formulated for optimizing a control cost of changing density of the agents from the initial density to the final density subject to dynamics of the agents in a density space. The first control problem, which is a non-linear non-convex problem over a multi-agent control and a density of the agents, is transformed into a second control problem over the density of the agents and a product of the multi-agent control and the density of the agents. The second control problem is a non-linear convex problem that is solved to produce the control input for each section of the state space. A motion of each agent is controlled according to a control input corresponding to its section of the state space.

Abstract: Disclosed is a biosensor, comprising: a sensor part including a capillary chip configured to detect a target material; and a pre-treatment part connected to the sensor part and configured to provide a mixed solution including a substrate to the sensor part, in which the capillary chip includes a capillary, at least one of antibody for antigen-antibody reaction with the target material inside the capillary, and a photo sensor detecting a color of the substrate.

Abstract: A substrate supporting apparatus includes a rotatable chuck, a first mass flow controller, a second mass flow controller, a plurality of locating pins and guiding pillars, and a motor in which the rotatable chuck defines a plurality of first injecting ports and second injecting ports, the first injecting ports are connected with a first gas passage for supplying gas to the substrate and sucking the substrate by Bernoulli effect, the second injecting ports are connected with a second gas passage for supplying gas to the substrate and lifting the substrate, the first and the second mass flow controllers are respectively installed on the first and the second gas passages, the plurality of locating pins and guiding pillars are disposed at the top surface of the rotatable chuck and every guiding pillar protrudes to form a holding portion, and the motor is used for rotating the rotatable chuck.

Abstract: A primary coil circuit of a ground assembly for wirelessly transferring power to a secondary coil includes: a primary coil magnetically coupled to the secondary coil and having a first terminal and a second terminal; a second capacitor having a first terminal and a second terminal connected to the first terminal of the primary coil; a first inductor having a first terminal coupled to a first input terminal of a power source and a second terminal coupled to the first terminal of the second capacitor; and a first capacitor having a first terminal coupled commonly to the second terminal of the first inductor and the first terminal of the second capacitor and a second terminal coupled commonly to the second terminal of the primary coil and a second input terminal of the power source.

Abstract: A motion of a vehicle is controlled according to a sequential compositions of the elementary paths following a transformation of one of a first pattern, a second pattern, and a third pattern. These three patterns are predetermined and form an exhaustive set of patterns. The three patterns are represented by corresponding functions stored in a memory. The functions representing the patterns are used, in response to receiving an initial state and a target state of the vehicle, to determine parameters of the minimum-curvature path. The motion of the vehicle is controlled according to the parameters of the minimum-curvature path.

Abstract: A measurement device for assessing knee movement comprises: an elongated base member; a moveable (or sliding) member configured for movement along and relative to the elongated base member; and indicia on an upper surface of the elongated base member to reflect the relative position of the moveable member with respect to the elongated base member. The measurement device may also include multiple blocks arranged in a stack on the elongated base member to measure knee extension of a patient.

Abstract: This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.

Abstract: A method of operating a rolling piston rotary compressor includes obtaining an angular position and an angular speed of a rolling piston of the compressor, for example, using a tachometer or shaft encoder or observer. The method further includes obtaining an electromagnetic torque applied by an electric motor that is mechanically coupled to the rolling piston. The method further includes calculating a load torque exerted on the rolling piston based on these obtained values by using a load torque observer model that is formulated using known geometries of the compressor and thermodynamic models for the gas compression process. The operation of the electric motor is then adjusted such that the electromagnetic torque applied by the motor is equivalent to the calculated load torque such that noise and vibrations are minimized.

Abstract: An apparatus 1 comprises a subject data obtaining unit 11 for obtaining subject data M4 of an inter-organ cross talk indicator in each organ other than a specific organ, a pattern similarity calculation unit 12 for calculating, by comparing the subject data M4 with standard data 1 of the inter-organ cross talk indicator, similarity of patterns of the inter-organ cross talk indicators, and a prediction unit 13 for predicting the presence of a specific disease and/or the stage of the specific disease by using the similarity as a measure.

Abstract: A method and apparatus for cleaning semiconductor wafer, combining batch cleaning and single wafer cleaning together. The method includes: taking at least two wafers from a cassette in a load port and putting said wafers into a first tank filled with chemical solution; after processing said wafers in the first tank, taking said wafers out of the first tank and keeping said wafers wet; putting said wafers into a second tank filled with liquid; after processing said wafers in the second tank, taking said wafers out of the second tank and keeping said wafers wet; putting one of said wafers on a chuck inside a single wafer cleaning module; rotating the chuck while applying chemical solution on said wafer; applying deionized water on said wafer; drying said wafer; taking said wafer out of the single wafer cleaning module and putting said wafer back to the cassette in the load port.