Abstract: Disclosed herein is a visual analytics system and method that provides a proactive and predictive environment in order to assist decision makers in making effective resource allocation and deployment decisions. The challenges involved with such predictive analytics processes include end-users' understanding, and the application of the underlying statistical algorithms at the right spatiotemporal granularity levels so that good prediction estimates can be established. In the disclosed approach, a suite of natural scale templates and methods are provided allowing users to focus and drill down to appropriate geospatial and temporal resolution levels. The disclosed forecasting technique is based on the Seasonal Trend decomposition based on Loess (STL) method applied in a spatiotemporal visual analytics context to provide analysts with predicted levels of future activity.

Abstract: The present invention relates to the use of cannabidiol (CBD) in the treatment of focal seizures. In one embodiment the patients suffering from focal seizures are children and young adults. CBD appears particularly effective in reducing focal seizures in patients suffering with etiologies that include: Lennox-Gastaut Syndrome; Tuberous Sclerosis Complex; Dravet Syndrome; CDKL5; Neuronal ceroid lipofuscinoses (NCL); febrile infection related epilepsy syndrome (FIRES); Aicardi syndrome and brain abnormalities in comparison to other seizure types. Significantly CBD additionally is very effective in the reduction of a sub-type of focal seizures, focal seizures with impairment.

Abstract: The present invention relates to a near-ultraviolet stimulated light-emitting compound, and more specifically relates to a fluorescent quinazolinone compound which is stimulated in the near ultraviolet region. The fluorescent quinazolinone compound according to the present invention is colourless in daylight but exhibits a high fluorescent intensity when irradiated with light in the near ultraviolet region. Also, the fluorescent quinazolinone compound can be easily used with printed and plastic moulded products since the compound not only has a high degree of light fastness and thermal stability but also high dispersibility.

Abstract: The invention relates to C-3 novel triterpenone with C-28 reverse amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.

Abstract: A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof.

Abstract: The present disclosure relates to methods of expressing therapeutic proteins in photosynthetic organisms and the therapeutic proteins produced by the methods. The therapeutic proteins include high-mobility group box 1 (HMGB1) protein, fibronectin domain (10) (10FN3), fibronectin domain (14) (14FN3), interferon beta (IFN?), proinsulin and vascular endothelial growth factor (VEGF). The photosynthetic organisms include prokaryotes such as cyanobacteria and eukaryotes such as alga and plants. Transformation of eukaryotes is preferably the plastid genome, more preferably the chloroplast genome.

Abstract: The present disclosure relates to an oral, extended release pill containing a drug which is homogenously spread throughout a matrix. The pill can be prepared using a hot melt extrusion process and a forming unit. The formed pill meets regulatory guidelines for extended release formulations and can be abuse deterrent to parenteral administration due at least to particle size, viscosity, or purity limitations.

Abstract: The present disclosure relates to an apparatus and method for discriminating biological tissue, and a surgical apparatus using the same, the biological tissue discriminating method being capable of exactly discriminating the biological tissue by measuring an impedance value per frequency, teaching the measured impedance value per frequency in a single classifier according to learning algorithms that are different from one another having the measured impedance value per frequency as an input variable to discriminate the biological tissue, and re-teaching the biological tissue discriminated from each single classifier in a meta classifier to finally discriminate the biological tissue.

Abstract: Gas separation processes are provided for separating dehydrogenation reaction products from a raw gas stream to recover hydrocarbons, specifically olefins, such as propylene and iso-butene, as well as unreacted feedstock. The processes employ a sequence of partial condensation steps, interspersed with membrane separation steps to raise the hydrocarbon dewpoint of the uncondensed gas, thereby avoiding the use of low-temperature or cryogenic conditions.

Abstract: Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using novel capsid-protein-mutated rAAV vector constructs in a variety of diagnostic and therapeutic applications including, inter alia, as delivery agents for diagnosis, treatment, or amelioration of one or more diseases, disorders, or dysfunctions of the mammalian eye. Also disclosed are methods for intravitreal delivery of therapeutic gene constructs to retinal neuron cells, and specifically to ON bipolar cells, of the mammalian eye, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications including the treatment of retinitis pigmentosa, melanoma-associated retinopathy, and congenital stationary night blindness.

Abstract: By supporting a space generated by a settlement of the track bed gravel or asphalt roadbed underneath a concrete rail tie with cylindrical rods, and installing the present invention, one each separately, on the left and right sides of the concrete rail tie, recovery from settlements is automatic, and the response to differential settlements of the left and right rails of the track due to the train load can be easily facilitated, and by installing pressure reducing valves on the upper part of the concrete rail ties, pressure can be reduced while maintaining the track system as is without having to dismantle the concrete rail ties, and accordingly the usability of the concrete rail ties can be improved.

Abstract: Provided is a method of synthesizing boron nitride, comprising the steps of: preparing a boron compound and a nitrogen compound; mixing the boron compound and the nitrogen compound in a non-aqueous solvent; forming an ester compound by melting the mixture in the non-aqueous solvent; dehydrating the ester compound; and forming boron nitride by nitriding the ester compound in a reductive atmosphere.

Abstract: A method for producing devulcanized rubber and an apparatus (100) therefor. The method for producing devulcanized rubber comprises the steps of (1) providing vulcanized rubber particles with a pre-determined particle size and (2) devulcanizing the vulcanized rubber particles. The vulcanized rubber particles are devulcanized mechanically by impact forces and devulcanized chemically by a chemical composition. The impact forces break sulphur-sulphur and sulphur-carbon bonds of the vulcanized rubber particles causing surfaces of the rubber to become receptive in reacting with the chemical composition and the chemical composition renders the sulphur passive to prevent reattachment of the bonds, of which the chemical composition comprises at least one accelerator, at least one inorganic activator and at least one organic activator.

Abstract: This document provides methods and materials related to making and using differentiated induced pluripotent stem cells. For example, methods and materials for making differentiated induced pluripotent stem cells (e.g., insulin-producing cells) that do not form cancer cells within a mammal (e.g., a human), cells that underwent guided differentiation from induced pluripotent stem cells, compositions containing cells that underwent guided differentiation from induced pluripotent stem cells, and methods for using cells that underwent guided differentiation from induced pluripotent stem cells (e.g., methods for using such cells to treat diabetes or to repair cardiovascular tissue) are provided.

Abstract: A photoelectric hybrid device includes an optical connector on a flat optical surface at one end of vertical optical waveguides for inputting and outputting an optical signal. Integration of the photoelectric hybrid device into an interposer or the like is standardized. The photoelectric hybrid device includes: conductive pins connected to an electric signal pathway for a photoelectric hybrid substrate; a translucent member having a flat optical surface and a translucent part; and self-organizing optical waveguides that form an optical path between the translucent part and an optical waveguide. The flat optical surface is not lower than the tops of the electrical connection parts on the conductive pins. Collision of the optical connector and the tops of the electrical connection parts can be avoided when an optical connector on which an optical waveguide that transmits an optical signal among the optical waveguides.

Abstract: An adeno-associated virus filler component comprising a nucleic acid of between 3300 and 4200 nucleotides in length is disclosed.

Abstract: The system for testing stress corrosion cracking (SCC) includes an autoclave having at least one heating element selectively actuated to heat the interior portion of the autoclave, the autoclave being configured for receiving a liquid and/or gas and for forming a corrosive fluid. The system also includes a circulation assembly having a flow line and a test section line. A plurality of test sections is positioned in series along the test section line and configured for receiving the corrosive fluid via the test section line once the required temperature is reached to expose the specimens directly to the corrosive fluid, the fluid flowing through a section of the flow line parallel to the test section line until the required temperature is reached. The circulation assembly includes a circulating pump, a flowmeter positioned along the flow line, and a pressure assembly mounted on the autoclave.

Abstract: A method for facilitating secured data processing, the method includes generating, for each client out of at least two clients, a private key, and a public key; and storing at least the private keys at highly secured entity; whereas the highly secured entity is operable to utilize at least a the private key to perform public key infrastructure processing.

Abstract: The invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis. In particular, the invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis by decreasing the expression of a cytoplasmic granule toxin in astrocytes of a patient, or by increasing the expression of MHC class I in motor neurons of the patient.

Abstract: A high-speed stack molding device utilizing a rotary multi-mould, including a base having a moving rail formed on an upper surface thereof; a mould-rotating unit disposed on the base and supporting both ends of a multi-mould to selectively rotate the multi-mould; a movable driving frame including vertical frames extending upward from slide-coupling parts, which are moved forward and rearward along the moving rail and an upper frame connecting upper end portions of the vertical frames to cover an upper portion of the multi-mould; a fiber-reinforced resin supplying unit connected to the movable driving frame and supplying a fiber discharged from a supplying roller to the upper frame through pressure rollers; and a stacking head provided at an end portion of an articulated robot arm connected operably to the upper frame for pressurizing and stacking the fiber-reinforced resin.