Abstract: A monolithic integrated circuit including an image sensor for capturing image information; at least one analog to digital convertor for converting analog signals corresponding to the image information into digital image data; and an image processor, the image processor including a low-pass filter for filtering the image data, thereby to generate filtered image data.

Abstract: An extensive series of CBI analogues of the duocarmycins and CC-1065 exploring substituent effects within the first indole DNA binding subunit is detailed. In general, substitution at the indole C5 position led to cytotoxic potency enhancements that can be ?1000-fold providing simplified analogues containing a single DNA binding subunit that are more potent (IC50=2-3 pM) than CBI-TMI, duocarmycin SA, or CC-1065. The increases in cytotoxicity correlate well with accompanying increases in the rate and efficiency of DNA alkylation. This effect is more pronounced with the CBI versus DSA or CPI based analogues. Moreover, this effect is largely insensitive to the electronic character of the C5 substituent but is sensitive to the size, rigid length, and shape (sp, sp2, sp3 hybridization) of this substituent consistent with expectation that the impact is due simply to its presence.

Abstract: Microfluidics packages and methods of use are described, comprising in one embodiment a substrate having a top surface and means to lower pressure on the top surface; a fluidics card having a bottom surface and means to allow fluids to traverse through the card; and a polymeric barrier film, the polymeric barrier film positioned between the top surface of the substrate and the bottom surface of the fluidics card.

Abstract: A method is used to remove an unreacted alcohol from an ester product mixture by a gas stripping. The method involves the feeding of the ester product mixture into proximity of an axis of a rotating packed bed, so as to enable the ester product mixture to flow radially to come in contact with a gas which is introduced into the rotating packed bed. The unreacted alcohol and any other volatile component of low molecular weight are thus stripped from the ester product mixture by the gas entrainment, thereby resulting in production of a purified ester product which is collected at the bottom of the rotating packed bed. The unreacted alcohol and the volatile component, which are entrained in the gas, are discharged via an exit located at the top of the rotating packed bed.

Abstract: Mechanisms for passive gravity compensation for a system of linkage arms are provided. Gravity compensation is provided through a pair of non-circular gear profiles, with an end of each linkage arm connected to a separate gear set of two non-circular cam bodies, by way of separate cables. Springs in the gear sets provide tension in the cables. The tension in each cable varies according to the angle through which the cam bodies have turned as a result of the co-operating non-circular surfaces of the cam bodies. This, in turn is based on the amount the arms have turned and thereby allows the tension in the cables to compensate for the moments on the arms due to gravity, whatever angles they are at, independently of the angle of the other arm. To achieve this for the first arm of the linkage, the tension in the cable leading to the second arm of the linkage is also transmitted as a torque to the first arm through a pulley mounted on the rotation axis of the first arm.

Abstract: A monolithic integrated circuit including an image sensor for capturing image information; at least one analog to digital converter for converting analog signals corresponding to the image information into digital image data; and a first framestore for storing frames of the digital image data.

Abstract: A single monolithic semiconductor substrate comprises a first side and a second side. The first side includes an air bearing surface. A laser integrates with the first side. The laser has an emission facet substantially co-planer with the air bearing surface. A contact pad on the second side electronically bridges to the laser.

Abstract: A printing assembly for printing on porous sheets of media from a stack of such sheets includes a retaining structure that is configured to retain the stack in an aligned condition. A pick-up device on the retaining structure includes a gas conduit that is in fluid communication with a gas supply and a nozzle arrangement that is in fluid communication with the gas conduit. The nozzle arrangement is shaped to define a pick-up surface. The pick-up device is displaceable along a feed path relative to the retaining structure. The nozzle arrangement is capable of directing a flow of gas onto a first sheet of the stack such that the gas passes partially through the first sheet and impinges on a second sheet, generating a cushion of air between the first and second sheets to separate the first and second sheets. The gas supply is reversible so that the first sheet can be drawn towards the pick-up surface and retained against the pick-up surface.

Abstract: A camera and method for the creation of texturing effects in output images. The camera includes a sensor for sensing an image and a texture mapper for adding texturing effect to the sensed image to produce a textured image. The camera also includes a display for displaying the textured image. In one form, the display is a printer for printing out immediate photos by the camera.

Abstract: An optical fiber includes a core for guiding light of a specified range of wavelengths therethrough, each wavelength in the specified range of wavelengths traveling through the core at a particular group velocity and the light potentially producing a nonlinear optical effect. The optical fiber also includes a cladding formed around the core for substantially containing the light within the core. The optical fiber further includes a predetermined amount of at least one dopant uniformly dispersed throughout the core such that no two distinct wavelengths in the specified range of wavelengths travel through the core at the same, particular group velocity, thereby causing the nonlinear optical effect to be suppressed.

Abstract: A reaction cassette has been designed for the highly sensitive detection of the making and breaking of chemical bonds. The system may be employed as a companion device to be used in the search for antibody and other novel catalysts. The cassette also has important clinical applications in the design of diagnostic reagents. In its fully encoded format this methodology is capable of both detecting and decoding chemical events.

Abstract: The invention relates to a novel lipid kinase which is part of the PI3 Kinase family. PI3 Kinases catalyze the addition of phosphate to inositol generating inositol mono, di and triphosphate. Inositol phosphates have been implicated in regulating intracellular signaling cascades resulting in alternations in gene expression which, amongst other effects, can result in cytoskeletal remodeling and modulation of cellular motility. More particularly the invention relates to a novel human PI3 Kinase, p110? which interacts with p85, has a broad phosphinositide specificity and is sensitive to the same kinase inhibitors as PI3 Kinase p110A. However, in contrast to previously identified PI3 Kinases which show a ubiquitous pattern of expression, p110? is selectively expressed in leucocytes. Importantly, p110? shows enhanced expression in most melanomas tested and therefore may play a crucial role in regulating the metastatic property exhibited by melanomas.

Abstract: The present invention provides a method of clonal propagation of Pandanus amaryllifolius and further provides a composition for the clonal propagation of scented Pandanus amaryllifolius.

Abstract: The present invention pertains to a method for efficiently introducing exogenous genes into stem cells, particularly human stem cells. The method optionally includes the steps of inducing the proliferation of target cells by pre-stimulation with cytokines and/or growth factors, followed by incubating these cells with RD114-pseudotyped vector particles. In a specific embodiment, the vector particles are retronectin-immobilized or ultracentrifugation-concentrated retroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein. The present invention further discloses a method for somatic gene therapy, which can be used for various therapeutic applications and involves introducing a gene of interest contained within the retroviral genome into human repopulating stem cells followed by introducing these cells into a human host.

Abstract: A computer product for determining thermodynamic properties of a natural gas hydrocarbon, when the speed of sound in the gas is known at an arbitrary temperature and pressure. Thus, the known parameters are the sound speed, temperature, pressure, and concentrations of any dilute components of the gas. The method uses a set of reference gases and their calculated density and speed of sound values to estimate the density of the subject gas. Additional calculations can be made to estimate the molecular weight of the subject gas, which can then be used as the basis for mass flow calculations, to determine the speed of sound at standard pressure and temperature, and to determine various thermophysical characteristics of the gas.

Abstract: A system for executing diagnosis of vehicle performance using satellite telemetry technology includes a diagnostic unit for compiling telemetry data, transmitted in real-time, of an engine and various parts of a vehicle, comparing the telemetry data with specific values of the engine and various parts to determine if there are any abnormalities in vehicle performance, and monitoring diagnostic results of vehicle performance; and a communications unit for performing communications in real-time through a network with an external user requesting vehicle performance diagnostic results of the diagnostic unit. Accordingly, the driver or external user may easily determine if there are abnormalities in vehicle performance, take steps to cope with vehicle malfunctions before they occur, and know the precise location of any abnormal areas of vehicle performance.

Abstract: This invention provides for a method of inducing a current in the heart in a subject which comprises contacting a cell of the heart of a subject with a compound in a sufficient amount to induce a current in the cell of the heart of a subject. This invention also provides a method of treating a cardiac condition in a subject which comprises contacting a cell of the heart of the subject with a compound in an amount sufficient to increase the current expression of the cell, thereby treating the cardiac condition in the subject.

Abstract: Carbonaceous, composite tooling fabricated from pitch-based or coal-based cellular or porous products, “carbonaceous foams” having a density of preferably between about 0.1 g/cm3 and about 0.8 g/cm3 that are produced by: 1) conventional pitch foaming processes or; 2) the controlled beating of coal particulate preferably up to ¼ inch in diameter in a “mold” and under a non-oxidizing atmosphere. According to a specifically preferred embodiment, the starting material coal has a free swell index as determined by ASTM test D720 of between about 3.5 and about 5.0.

Abstract: The invention provides methods to detect VZV in biological samples using real-time PCR. Primers and probes for the detection of VZV are provided by the invention. Articles of manufacture containing such primers and probes for detecting VZV are further provided by the invention.

Abstract: A finite impulse response filter of 1:4 interpolation with 108 taps for outputting filter output data of 8 bits with respect to filter input data of 4 bits includes four shifting and storing unit of 27 bits for unifying bits of filter input data of 4 bits, which is 2's complement to shift and store the bi-unified input data, first selection unit for selecting any one of the input data stored in the four shifting and storing unit of 27 bits, address generating unit for generating addresses of lookup tables corresponding to each of a plurality of filter coefficients groups, first to fourth lookup table groups for generating filter outputs of each filter coefficients group, four accumulating unit for shifting the filter outputs of the filter coefficients groups respectively outputted in parallel from the first to the fourth lookup table groups, and second selection unit for serially converting the outputs from each of the four accumulators in accordance with filter coefficients groups.