Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

Abstract: Systems and methods of controlling a charging status indicator in a charging system for a device having a rechargeable power supply are provided. The charging system determines whether a device connected thereto supports remote control of the charging status indicator, and controls the charging status indicator as directed by the device where the device supports remote control of the charging status indicator.

Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.

Abstract: The invention provides a separation method for object and glue membrane, and it is characterized: an external force such as tearing apart is pre-applied for appropriately separating the glue membrane and the object, such that the binding ability between the object and the glue membrane is reduced, and a taking-and-placing head then sucks up the object; to achieve said objective, it can arrange a vacuum sucking-up seat that is moveable and has vacuum adsorption hole under the glue membrane, and the sucking force of the vacuum sucking-up seat may generate an external force such as tearing apart to the glue membrane, and the object is then sucked up by the taking-and-placing head; it is also possible to arrange a connection rod to lower down and lift up the taking-and-placing head simultaneously and, before the taking-and-placing head is lowered down to contact the object, it may bring along the connection rod to press down the glue membrane and generate an external force such as tearing apart to the glue membra

Abstract: In the IS process, the reaction between sulfur and water is performed on the positive electrode side of a cation exchange membrane and the iodine-involving reaction is on the negative electrode side, so that the subsequent separating operation is eliminated to reduce the amounts of recycling iodine and water.

Abstract: Particles which include a bioactive agent are prepared to have a desired matrix transition temperature. Delivery of the particles via the pulmonary system results in modulation of drug release from the particles. Sustained release and/or sustained pharmacologic action of the drug can be obtained by forming particles which include a combination of phospholipids that are miscible in one another and have a high matrix transition temperature.

Abstract: A composite bipolar plate of polymer electrolyte membrane fuel cells (PEMFC) is prepared as follows: a) preparing a bulk molding compound (BMC) material containing a vinyl ester resin and a graphite powder, the graphite powder content of BMC material ranging from 60 wt % to 80 wt %, based on the compounded mixture; b) molding the BMC material from step a) to form a bipolar plate having a desired shape at 80-200° C. and 500-4000 psi, wherein the graphite powder is of 40 mesh-80 mesh.

Abstract: The present invention describes methods for inhibition angiogenesis in tissues using vitronectin ?v?3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in tumor tissues and metastases using therapeutic compositions containing ?v?3 antagonists.

Abstract: The shaft includes two electrically conducting connecting pieces (2, 3), which can be connected to different electric potentials, and also an insulating tube (4), which can be subjected to torsional loading. The two connecting pieces (2, 3) are respectively fastened to one of the two ends of the insulating tube (4). In order that the shaft can also transmit great torques, the following means are provided for fastening at least one of the two connecting pieces (2, 3): An adhesive joint (5), which is formed by a cone (6) formed into one end of the insulating tube (4) and made to run from the circumferential surface (7) to the inner surface (8) of the insulating tube (4) and also by a mating cone (9) formed into the at least one connecting piece (2, 3), and by a gap (10) formed by the cone (6) and mating cone (9) and filled with adhesive.

Abstract: The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester ? N-acetyl glucosimanidase (phosphodiester ?-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal bydrolases having an N-acetylglucosamine-1-phosphate.

Abstract: The genomic structure including the sequence of the intron/exon junctions is disclosed for KVLQT1 and KCNE1 which are genes associated with long QT syndrome. Additional sequence data for the two genes ARE also disclosed. Also disclosed are newly found mutations in KVLQT1 which result in long QT syndrome. The intron/exon junction sequence data allow for the design of primer pairs to amplify and sequence across all of the exons of the two genes. This can be used to screen persons for the presence of mutations which cause long QT syndrome. Assays can be performed to screen persons for the presence of mutations in either the DNA or proteins. The DNA and proteins may also be used in assays to screen for drugs which will be useful in treating or preventing the occurrence of long QT syndrome.

Abstract: Multiple function current-sharing charging systems aid methods are provided. Where first and second rechargeable power supplies are connected to a charging system, a first charging current is provided to the first rechargeable power supply and a second charging current is provided to the second rechargeable power supply. Upon detection of a predetermined charge level of one of the rechargeable power supplies, a third charging current is provided to the first rechargeable power supply and a fourth charging current is provided to the second rechargeable power supply.

Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

Abstract: The present invention discloses a concept of natural index contrast (NIC) for producing photonic waveguides and methods of fabrication thereof. Such waveguide forms the basis of a class of chip-scale micro- and nano-photonic integrated circuits (PICs). The NIC method utilizes the built-in refractive index difference between two layers of dielectric thin films of two different materials, one laid on top of another. This new class of waveguides simplifies the PIC fabrication process significantly. Based on the NIC based waveguides, PICs can be fabricated for a number of photonic applications such as arrayed waveguide grating (AWG), reflective arrayed waveguide grating (RAWG), interleaver, interferometer, and optical sensor. Additionally, several other PICs can also be fabricated via tiers of integration, such as triple-phase integration.

Abstract: The present invention relates to pharmaceutical compositions and formulations comprising a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor.

Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.

Abstract: An optical waveguide platform and a method of manufacturing the same are disclosed. The optical waveguide platform comprises an optical waveguide having a lower clad layer, a patterned core layer and an upper clad layer which are laminated on one area of said substrate sequentially, a terrace formed by patterning said lower clad layer, on the other area of said substrate, a metal and a solder formed on said terrace and an optical device mounted on said terrace containing said metal and said solder. According to the present invention, the optical waveguide platform can be manufactured in a simple method without damaging the optical waveguide and the manufacturing cost thereof can be reduced.

Abstract: The present invention provided with novel 5-benzyloxymethyl-1,2-isoxazoline derivatives of the formula (1), their preparation method and their use as herbicides. The 5-benzyloxymethyl-1,2-isoxazoline derivatives according to the present invention have sufficiently high herbicidal activity against the weeds in the paddy field rice even at low dose rates and excellent selectivity to transferred rice in particular. As thus, the compounds of the present invention are typically useful as herbicides for control of paddy weeds in rice.

Abstract: A digital receiver detects symbols in a baseband signal in a DS-CDMA network. The receiver includes multiple spaced apart antennas. A time-frequency rake receiver is connected to each of the antennas. An interference canceller is connected to each output of each of the rake receiver. Each interference canceller produces a contributing symbol in parallel. A diversity combiner determines a decision symbol corresponding to the baseband signal from the contributing symbols.

Abstract: This invention relates to a fluid driven agitator used in densified gas cleaning system, which comprises a hydraulic motor mounted to a cleaning vessel of the densified gas cleaning system, wherein the hydraulic motor comprises a fluid in-port for charging the fluid into the hydraulic motor from outside of the cleaning vessel, and a fluid out-port for discharging the fluid from the hydraulic motor out of the cleaning vessel. An output shaft of the hydraulic motor can be joined to a rotatable component, such as a rotary basket or an impeller, subjecting circulation of the fluid and resulting in stirring.