Patents Assigned to RESET THERAPEUTICS, INC.
  • Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
    Patent number: 10214507
    Abstract: The subject matter herein is directed to carbazole-containing amide, carbamate, and urea derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, D, E, G, J, L, M, Q, a, and b are accordingly described. Also provided are pharmaceutical compositions containing the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, complications associated with diabetes, Cushing's syndrome, NASH, NAFLD, asthma, and COPD.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: February 26, 2019
    Assignee: Reset Therapeutics, Inc.
    Inventors: Ross Bersot, Paul Humphries
  • Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
    Patent number: 10005759
    Abstract: The subject matter herein is directed to carbazole-containing amide, carbamate, and urea derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, D, E, G, J, L, M, Q, a, and b are accordingly described. Also provided are pharmaceutical compositions containing the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, complications associated with diabetes, Cushing's syndrome, NASH, NAFLD, asthma, and COPD.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: June 26, 2018
    Assignee: Reset Therapeutics, Inc.
    Inventors: Ross Bersot, Paul Humphries
  • Carbazole-containing sulfonamides as cryptochrome modulators
    Patent number: 9775845
    Abstract: The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C?, D, E, F, G, H?, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: October 3, 2017
    Assignee: Reset Therapeutics, Inc.
    Inventors: Ross Bersot, Paul Humphries
  • Carbazole-containing sulfonamides as cryptochrome modulators
    Patent number: 9265772
    Abstract: The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: February 23, 2016
    Assignee: RESET THERAPEUTICS, INC.
    Inventors: Ross Bersot, Paul Humphries