Abstract: The present application relates to a novel polymorphic form of cabergoline comprising cabergoline and t-amyl methyl ether, designated Form TAME cabergoline, together with a novel method of producing cabergoline.
Type:
Application
Filed:
February 7, 2007
Publication date:
August 23, 2007
Applicant:
Resolution Chemicals Limited
Inventors:
Alan Greenwood, Parveen Bhatarah, Raza Mahmood, Derek McHattie
Abstract: A sterilisable particle-size reduction apparatus, component parts thereof and a method of sterilising and validating sterility thereof are provided. Also provided is use thereof to prepare sterile suspensions of drugs.
Type:
Application
Filed:
August 19, 2004
Publication date:
December 14, 2006
Applicant:
Resolution Chemicals Limited
Inventors:
Alan Greenwood, Parveen Bhatarah, Gary Hembra, Derek McHattie
Abstract: Disclosed is a process for the synthesis of 17?-hydroxy-7?-methyl-19-nor-17?-pregn-5(10)-ene-20-yne-3-one (ti-bolone, 11) and intermediates useful for the synthesis thereof: (11).
Type:
Application
Filed:
March 3, 2004
Publication date:
August 3, 2006
Applicant:
Resolution Chemicals Limited
Inventors:
Alan Greenwood, Derek McHattie, Parveen Bhatarah
Abstract: Preparation of citalopram comprises the steps of: (a) converting the compound of Formula (I) to a compound of Formula (II), wherein R in Formula (I) represents a C2 to C5 alkylene group which may be substituted or unsubstituted, and R1 in the compounds of Formula (II) represents a carboxylic acid group or a salt or an ester thereof; and (b) converting the compound of Formula (II) to form citalopram or a pharmaceutically acceptable salt thereof, or a direct conversion of the compound of Formula (I) to citalopram
Type:
Grant
Filed:
March 7, 2001
Date of Patent:
February 21, 2006
Assignee:
Resolution Chemicals Limited
Inventors:
Alan K. Greenwood, Derek McHattie, Josef A. Rechka, Paul C. M. Hedger, Mark P. Gamble