Abstract: Methods of treatment comprising administering a compound having structure (I), or a pharmaceutically acceptable salt thereof, or administering a pharmaceutical composition comprising the compound of structure (I) or pharmaceutically acceptable salt thereof, are provided.
Abstract: Compounds having the following formula (E): or a pharmaceutically acceptable salt thereof, wherein R, R?, R?, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.
Type:
Grant
Filed:
January 5, 2018
Date of Patent:
September 10, 2019
Assignee:
Retrophin, Inc.
Inventors:
Andrew Vaino, Marek Biestek, Martin Shkreli
Abstract: Compounds having the following formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, D, E and R1 are as defined herein, are provided. Methods comprising the use of such compounds for the treatment of neurological disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in the treatment of neurological disorders, also are provided.
Type:
Grant
Filed:
December 8, 2016
Date of Patent:
July 30, 2019
Assignee:
Retrophin, Inc.
Inventors:
Maria Beconi, Daniel Elbaum, Steven Harper, Savina Malancona
Abstract: Compounds having the following formula (E): Formula E or a pharmaceutically acceptable salt thereof, wherein R, R?, R?, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.
Type:
Grant
Filed:
October 27, 2014
Date of Patent:
February 20, 2018
Assignee:
Retrophin, Inc.
Inventors:
Andrew Vaino, Marek Biestek, Martin Shkreli
Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
Type:
Grant
Filed:
September 30, 2015
Date of Patent:
April 25, 2017
Assignee:
Retrophin, Inc.
Inventors:
Andrew Vaino, Marek Biestek, Martin Shkreli
Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
Type:
Grant
Filed:
January 16, 2014
Date of Patent:
November 10, 2015
Assignee:
Retrophin, Inc.
Inventors:
Andrew Vaino, Marek Biestek, Martin Shkreli
Abstract: Methods and compositions containing oxytocin or an oxytocin analog, such as carbetocin, are provided for the prevention and treatment of autism spectrum disorders, related disorders and symptoms of such disorders. The methods and compositions of this disclosure are effective in the treatment of social withdrawal, eye contact avoidance, repetitive behaviors, anxiety, attention deficit, hyperactivity, depression, loss of speech, verbal communication difficulties, aversion to touch, visual difficulties, comprehension difficulties, and sound and light sensitivity. Additional compositions and methods are provided which employ oxytocin or an oxytocin analog in combination with a secondary or adjunctive therapeutic agent to yield more effective treatment tools against autism spectrum disorders and related disorders.
Type:
Grant
Filed:
August 5, 2011
Date of Patent:
May 5, 2015
Assignee:
Retrophin, Inc.
Inventors:
Alexis Kays Leonard, Joshua Orion Sestak, Henry R. Costantino, Anthony P. Sileno, Lalit Raj Peddakota, Kayvon Emile Sharghi, Garland M. Bellamy, Jason Philip Gesty, Steven C. Quay
Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
Type:
Application
Filed:
January 16, 2014
Publication date:
May 15, 2014
Applicant:
Retrophin, Inc.
Inventors:
Andrew VAINO, Marek Biestek, Martin Shkreli
Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
Type:
Grant
Filed:
April 26, 2013
Date of Patent:
March 18, 2014
Assignee:
Retrophin, Inc.
Inventors:
Andrew Vaino, Marek Biestek, Martin Shkreli
Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
Type:
Application
Filed:
April 26, 2013
Publication date:
October 31, 2013
Applicant:
Retrophin, Inc.
Inventors:
Andrew VAINO, Marek Biestek, Martin Shkreli