Patents Assigned to Retrophin, Inc.
  • Patent number: 10864197
    Abstract: Methods of treatment comprising administering a compound having structure (I), or a pharmaceutically acceptable salt thereof, or administering a pharmaceutical composition comprising the compound of structure (I) or pharmaceutically acceptable salt thereof, are provided.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: December 15, 2020
    Assignee: RETROPHIN, INC.
    Inventors: Radko Komers, Alvin Shih
  • Patent number: 10407447
    Abstract: Compounds having the following formula (E): or a pharmaceutically acceptable salt thereof, wherein R, R?, R?, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: September 10, 2019
    Assignee: Retrophin, Inc.
    Inventors: Andrew Vaino, Marek Biestek, Martin Shkreli
  • Patent number: 10364263
    Abstract: Compounds having the following formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, D, E and R1 are as defined herein, are provided. Methods comprising the use of such compounds for the treatment of neurological disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in the treatment of neurological disorders, also are provided.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: July 30, 2019
    Assignee: Retrophin, Inc.
    Inventors: Maria Beconi, Daniel Elbaum, Steven Harper, Savina Malancona
  • Patent number: 9896464
    Abstract: Compounds having the following formula (E): Formula E or a pharmaceutically acceptable salt thereof, wherein R, R?, R?, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: February 20, 2018
    Assignee: Retrophin, Inc.
    Inventors: Andrew Vaino, Marek Biestek, Martin Shkreli
  • Patent number: 9629862
    Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: April 25, 2017
    Assignee: Retrophin, Inc.
    Inventors: Andrew Vaino, Marek Biestek, Martin Shkreli
  • Patent number: 9181286
    Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: November 10, 2015
    Assignee: Retrophin, Inc.
    Inventors: Andrew Vaino, Marek Biestek, Martin Shkreli
  • Patent number: 9023793
    Abstract: Methods and compositions containing oxytocin or an oxytocin analog, such as carbetocin, are provided for the prevention and treatment of autism spectrum disorders, related disorders and symptoms of such disorders. The methods and compositions of this disclosure are effective in the treatment of social withdrawal, eye contact avoidance, repetitive behaviors, anxiety, attention deficit, hyperactivity, depression, loss of speech, verbal communication difficulties, aversion to touch, visual difficulties, comprehension difficulties, and sound and light sensitivity. Additional compositions and methods are provided which employ oxytocin or an oxytocin analog in combination with a secondary or adjunctive therapeutic agent to yield more effective treatment tools against autism spectrum disorders and related disorders.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: May 5, 2015
    Assignee: Retrophin, Inc.
    Inventors: Alexis Kays Leonard, Joshua Orion Sestak, Henry R. Costantino, Anthony P. Sileno, Lalit Raj Peddakota, Kayvon Emile Sharghi, Garland M. Bellamy, Jason Philip Gesty, Steven C. Quay
  • Publication number: 20140135294
    Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
    Type: Application
    Filed: January 16, 2014
    Publication date: May 15, 2014
    Applicant: Retrophin, Inc.
    Inventors: Andrew VAINO, Marek Biestek, Martin Shkreli
  • Patent number: 8673883
    Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: March 18, 2014
    Assignee: Retrophin, Inc.
    Inventors: Andrew Vaino, Marek Biestek, Martin Shkreli
  • Publication number: 20130289001
    Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.
    Type: Application
    Filed: April 26, 2013
    Publication date: October 31, 2013
    Applicant: Retrophin, Inc.
    Inventors: Andrew VAINO, Marek Biestek, Martin Shkreli