Abstract: The present invention provides therapy and prophylaxis against HIV-induced AIDS, as well as methods for ascertaining the susceptibility of an individual to HIV-induced AIDS, the invention being based on the discovery that AIDS results from gp120 of HIV mimicking the antigen-presenting component of the immune system, thereby spuriously activating certain CD4+ T cells in susceptible individuals, leading to a condition similar to graft versus host disease, the condition being treatable by eliminating the responsible T cells, for example.
Type:
Grant
Filed:
October 14, 1994
Date of Patent:
August 10, 1999
Assignee:
Retroscreen Limited
Inventors:
John Anthony Habeshaw, Angus George Dalgleish, Elizabeth Hounsell, Lynne Bountiff