Patents Assigned to RETROTOPE, INC.
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Publication number: 20240091188Abstract: Disclosed are methods or dosing protocols for administering deuterated arachidonic acid or a prodrug thereof to a patient in order to accelerate the time required to achieve of a therapeutic concentration of 13,13-D2-arachidonic acid in vivo.Type: ApplicationFiled: February 4, 2022Publication date: March 21, 2024Applicant: Retrotope, Inc.Inventors: Peter Milner, Mikhail Sergeevich Shchepinov
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Patent number: 11510889Abstract: Disclosed are methods for inhibiting the progression of neurodegenerative disease. The methods include administering to a patient suffering from such a disease a composition comprising either deuterated arachidonic acid or an ester thereof.Type: GrantFiled: August 20, 2021Date of Patent: November 29, 2022Assignee: Retrotope, Inc.Inventors: Peter Milner, Mikhail Sergeevich Shchepinov
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Patent number: 11510888Abstract: Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD).Type: GrantFiled: October 30, 2019Date of Patent: November 29, 2022Assignee: Retrotope, Inc.Inventor: Mikhail S. Shchepinov
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Patent number: 11491130Abstract: Disclosed are methods for inhibiting the progression of neurodegenerative disease. The methods include administering to a patient suffering from such a disease a composition comprising either deuterated linoleic acid or an ester thereof.Type: GrantFiled: August 2, 2021Date of Patent: November 8, 2022Assignee: Retrotope, Inc.Inventors: Peter Milner, Mikhail Sergeevich Shchepinov
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Patent number: 11453637Abstract: Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.Type: GrantFiled: December 9, 2019Date of Patent: September 27, 2022Assignee: Retrotope, Inc.Inventors: Dragoslav Vidovic, Mikhail Sergeevich Shchepinov
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Patent number: 11447441Abstract: Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.Type: GrantFiled: August 26, 2021Date of Patent: September 20, 2022Assignee: Retrotope, Inc.Inventors: Dragoslav Vidovic, Mikhail Sergeevich Shchepinov
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Patent number: 11351143Abstract: Disclosed are methods for inhibiting the progression of Amyotrophic Lateral Sclerosis (ALS). The methods include administering to a patient suffering from ALS a composition comprising either deuterated linoleic acid or an ester or deuterated arachidonic acid or an ester thereof.Type: GrantFiled: February 5, 2021Date of Patent: June 7, 2022Assignee: RETROTOPE, INC.Inventors: Peter Milner, Mikhail Sergeevich Shchepinov
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Patent number: 11285125Abstract: Some aspects of the invention provide for a method of treating Wet and/or Dry Age-related Macular Degeneration, Retinitis Pigmentosa, Diabetic Retinopathy, cataracts, and/or Stargardt Disease using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.Type: GrantFiled: August 21, 2018Date of Patent: March 29, 2022Assignee: Retrotope, Inc.Inventor: Mikhail S. Shchepinov
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Patent number: 11241409Abstract: Some aspects of the invention provide for a method of treating Alzheimer's Disease, Mild Cognitive Impairment, Frontotemperal Dementia, Amyotrophic Lateral Sclerosis and/or Multiple Sclerosis using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.Type: GrantFiled: October 26, 2018Date of Patent: February 8, 2022Assignee: Retrotope, Inc.Inventor: Mikhail S. Shchepinov
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Patent number: 11166930Abstract: Methods are provided of identifying a subject having impaired aldehyde dehydrogenase activity; and administering to the subject a compound comprising an isotopically-modified polyunsaturated fatty acid, an isotopically-modified polyunsaturated fatty acid ester, an isotopically-modified polyunsaturated fatty acid thioester, an isotopically-modified polyunsaturated fatty acid amide, a polyunsaturated fatty acid mimetic, or an isotopically-modified polyunsaturated fatty acid pro-drug, the compound having an isotopic modification that reduces oxidation of the compound, thereby reducing production in the subject of substrate for aldehyde dehydrogenase. Some aspects provide coadministering an isotopically-modified polyunsaturated fatty acid and an oxylipin.Type: GrantFiled: November 16, 2017Date of Patent: November 9, 2021Assignee: RETROTOPE, INC.Inventor: Mikhail Sergeevich Shchepinov
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Publication number: 20210252173Abstract: Methods are provided for treating a subject having, or at risk of, a lysosomal storage disease, particularly Tay-Sachs, Gaucher disease, Sandhoff disease or Niemann-Pick disease, neuronal ceroid lipofuscinosis, or a condition associated with impaired Phospholipase A2 Group VI (PLA2G6) activity, particularly infantile neuroaxonal dystrophy or PLA2G6 associated neurodegeneration (PLAN), or a sleeping disorder, using a substituted polyunsaturated fatty acid, polyunsaturated fatty acid ester, polyunsaturated fatty acid thioester, fatty acid amide, polyunsaturated fatty acid mimetic, polyunsaturated fatty acid pro-drug, or combinations thereof, where the substituted compound comprises at least one substitution that reduces oxidation of the compound. Preferably, the substituted compound is a deuterated polyunsaturated fatty acid, or an ethyl ester thereof, such as 11,11-D2-linoleic acid, 11,11-D2-linoleic acid ethyl ester, 11,11,14,14-D4-linolenic acid, or 11,11,14,14-D4-linolenic acid ethyl ester.Type: ApplicationFiled: April 18, 2019Publication date: August 19, 2021Applicant: Retrotope, Inc.Inventors: Mikhail S. SHCHEPINOV, Robert J. MOLINARI, Peter MILNER
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Patent number: 10918126Abstract: A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is 2H and/or at least one C atom is 13C. The nutrient is thus protected from, inter alia, active oxygen species.Type: GrantFiled: June 22, 2018Date of Patent: February 16, 2021Assignee: Retrotope, Inc.Inventor: Mikhail Sergeevich Shchepinov
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Patent number: 10730821Abstract: Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.Type: GrantFiled: September 9, 2016Date of Patent: August 4, 2020Assignee: Retrotope, Inc.Inventors: Dragoslav Vidovic, Mikhail Sergeevich Shchepinov
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Patent number: 10577304Abstract: Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.Type: GrantFiled: November 15, 2018Date of Patent: March 3, 2020Assignee: Retrotope, Inc.Inventors: Dragoslav Vidovic, Mikhail Sergeevich Shchepinov
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Patent number: 10154983Abstract: Some aspects of the invention provide for a method of treating Alzheimer's Disease, Mild Cognitive Impairment, Frontotemperal Dementia, Amyotrophic Lateral Sclerosis and/or Multiple Sclerosis using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.Type: GrantFiled: April 24, 2012Date of Patent: December 18, 2018Assignee: Retrotope, Inc.Inventor: Mikhail S. Shchepinov
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Patent number: 10154978Abstract: Some aspects of the invention provide for a method of treating hepatic disorders, lipidemias and cardiac-related risk factors using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.Type: GrantFiled: April 24, 2012Date of Patent: December 18, 2018Assignee: Retrotope, Inc.Inventor: Mikhail S. Shchepinov
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Patent number: 10058522Abstract: Some aspects of the invention provide for a method of treating Wet and/or Dry Age-related Macular Degeneration, Retinitis Pigmentosa, Diabetic Retinopathy, cataracts, and/or Stargardt Disease using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.Type: GrantFiled: April 24, 2012Date of Patent: August 28, 2018Assignee: Retrotope, Inc.Inventor: Mikhail S. Shchepinov
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Patent number: 10058612Abstract: Some aspects of the invention provide for a method of treating Impaired Energy Processing Disorders and Mitochondrial Deficiencies using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.Type: GrantFiled: April 24, 2012Date of Patent: August 28, 2018Assignee: Retrotope, Inc.Inventor: Mikhail S. Shchepinov
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Patent number: 10052299Abstract: Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD).Type: GrantFiled: October 29, 2010Date of Patent: August 21, 2018Assignee: Retrotope, Inc.Inventor: Mikhail S. Shchepinov
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Patent number: RE49238Abstract: Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD).Type: GrantFiled: August 19, 2020Date of Patent: October 11, 2022Assignee: Retrotope, Inc.Inventor: Mikhail S. Shchepinov