Patents Assigned to RETROTOPE, INC.
  • Publication number: 20240091188
    Abstract: Disclosed are methods or dosing protocols for administering deuterated arachidonic acid or a prodrug thereof to a patient in order to accelerate the time required to achieve of a therapeutic concentration of 13,13-D2-arachidonic acid in vivo.
    Type: Application
    Filed: February 4, 2022
    Publication date: March 21, 2024
    Applicant: Retrotope, Inc.
    Inventors: Peter Milner, Mikhail Sergeevich Shchepinov
  • Patent number: 11510889
    Abstract: Disclosed are methods for inhibiting the progression of neurodegenerative disease. The methods include administering to a patient suffering from such a disease a composition comprising either deuterated arachidonic acid or an ester thereof.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: November 29, 2022
    Assignee: Retrotope, Inc.
    Inventors: Peter Milner, Mikhail Sergeevich Shchepinov
  • Patent number: 11510888
    Abstract: Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD).
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: November 29, 2022
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov
  • Patent number: 11491130
    Abstract: Disclosed are methods for inhibiting the progression of neurodegenerative disease. The methods include administering to a patient suffering from such a disease a composition comprising either deuterated linoleic acid or an ester thereof.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: November 8, 2022
    Assignee: Retrotope, Inc.
    Inventors: Peter Milner, Mikhail Sergeevich Shchepinov
  • Patent number: 11453637
    Abstract: Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: September 27, 2022
    Assignee: Retrotope, Inc.
    Inventors: Dragoslav Vidovic, Mikhail Sergeevich Shchepinov
  • Patent number: 11447441
    Abstract: Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.
    Type: Grant
    Filed: August 26, 2021
    Date of Patent: September 20, 2022
    Assignee: Retrotope, Inc.
    Inventors: Dragoslav Vidovic, Mikhail Sergeevich Shchepinov
  • Patent number: 11351143
    Abstract: Disclosed are methods for inhibiting the progression of Amyotrophic Lateral Sclerosis (ALS). The methods include administering to a patient suffering from ALS a composition comprising either deuterated linoleic acid or an ester or deuterated arachidonic acid or an ester thereof.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: June 7, 2022
    Assignee: RETROTOPE, INC.
    Inventors: Peter Milner, Mikhail Sergeevich Shchepinov
  • Patent number: 11285125
    Abstract: Some aspects of the invention provide for a method of treating Wet and/or Dry Age-related Macular Degeneration, Retinitis Pigmentosa, Diabetic Retinopathy, cataracts, and/or Stargardt Disease using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: March 29, 2022
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov
  • Patent number: 11241409
    Abstract: Some aspects of the invention provide for a method of treating Alzheimer's Disease, Mild Cognitive Impairment, Frontotemperal Dementia, Amyotrophic Lateral Sclerosis and/or Multiple Sclerosis using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: February 8, 2022
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov
  • Patent number: 11166930
    Abstract: Methods are provided of identifying a subject having impaired aldehyde dehydrogenase activity; and administering to the subject a compound comprising an isotopically-modified polyunsaturated fatty acid, an isotopically-modified polyunsaturated fatty acid ester, an isotopically-modified polyunsaturated fatty acid thioester, an isotopically-modified polyunsaturated fatty acid amide, a polyunsaturated fatty acid mimetic, or an isotopically-modified polyunsaturated fatty acid pro-drug, the compound having an isotopic modification that reduces oxidation of the compound, thereby reducing production in the subject of substrate for aldehyde dehydrogenase. Some aspects provide coadministering an isotopically-modified polyunsaturated fatty acid and an oxylipin.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: November 9, 2021
    Assignee: RETROTOPE, INC.
    Inventor: Mikhail Sergeevich Shchepinov
  • Publication number: 20210252173
    Abstract: Methods are provided for treating a subject having, or at risk of, a lysosomal storage disease, particularly Tay-Sachs, Gaucher disease, Sandhoff disease or Niemann-Pick disease, neuronal ceroid lipofuscinosis, or a condition associated with impaired Phospholipase A2 Group VI (PLA2G6) activity, particularly infantile neuroaxonal dystrophy or PLA2G6 associated neurodegeneration (PLAN), or a sleeping disorder, using a substituted polyunsaturated fatty acid, polyunsaturated fatty acid ester, polyunsaturated fatty acid thioester, fatty acid amide, polyunsaturated fatty acid mimetic, polyunsaturated fatty acid pro-drug, or combinations thereof, where the substituted compound comprises at least one substitution that reduces oxidation of the compound. Preferably, the substituted compound is a deuterated polyunsaturated fatty acid, or an ethyl ester thereof, such as 11,11-D2-linoleic acid, 11,11-D2-linoleic acid ethyl ester, 11,11,14,14-D4-linolenic acid, or 11,11,14,14-D4-linolenic acid ethyl ester.
    Type: Application
    Filed: April 18, 2019
    Publication date: August 19, 2021
    Applicant: Retrotope, Inc.
    Inventors: Mikhail S. SHCHEPINOV, Robert J. MOLINARI, Peter MILNER
  • Patent number: 10918126
    Abstract: A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is 2H and/or at least one C atom is 13C. The nutrient is thus protected from, inter alia, active oxygen species.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: February 16, 2021
    Assignee: Retrotope, Inc.
    Inventor: Mikhail Sergeevich Shchepinov
  • Patent number: 10730821
    Abstract: Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: August 4, 2020
    Assignee: Retrotope, Inc.
    Inventors: Dragoslav Vidovic, Mikhail Sergeevich Shchepinov
  • Patent number: 10577304
    Abstract: Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: March 3, 2020
    Assignee: Retrotope, Inc.
    Inventors: Dragoslav Vidovic, Mikhail Sergeevich Shchepinov
  • Patent number: 10154983
    Abstract: Some aspects of the invention provide for a method of treating Alzheimer's Disease, Mild Cognitive Impairment, Frontotemperal Dementia, Amyotrophic Lateral Sclerosis and/or Multiple Sclerosis using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: December 18, 2018
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov
  • Patent number: 10154978
    Abstract: Some aspects of the invention provide for a method of treating hepatic disorders, lipidemias and cardiac-related risk factors using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: December 18, 2018
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov
  • Patent number: 10058522
    Abstract: Some aspects of the invention provide for a method of treating Wet and/or Dry Age-related Macular Degeneration, Retinitis Pigmentosa, Diabetic Retinopathy, cataracts, and/or Stargardt Disease using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: August 28, 2018
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov
  • Patent number: 10058612
    Abstract: Some aspects of the invention provide for a method of treating Impaired Energy Processing Disorders and Mitochondrial Deficiencies using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: August 28, 2018
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov
  • Patent number: 10052299
    Abstract: Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD).
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: August 21, 2018
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov
  • Patent number: RE49238
    Abstract: Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD).
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: October 11, 2022
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov