Patents Assigned to Reuter Chemische Apparatebau KG
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Publication number: 20230008387Abstract: The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, as in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrateand crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.Type: ApplicationFiled: September 9, 2022Publication date: January 12, 2023Applicant: REUTER CHEMISCHE APPARATEBAU KGInventors: Karl Reuter, Tobias Wedel, Viktor Meier, Mark Kantor, Vasyl Andrushko, Florian Stolz
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Publication number: 20200087257Abstract: The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, as in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrateand crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.Type: ApplicationFiled: September 23, 2019Publication date: March 19, 2020Applicant: REUTER CHEMISCHE APPARATEBAU KGInventors: Karl Reuter, Tobias Wedel, Viktor Meier, Mark Kantor, Vasyl Andrushko, Florian Stolz
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Patent number: 10464898Abstract: The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, and in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrate and crystalline (S)-3-aminopiperidine-di-hydrochloride-monohydrate.Type: GrantFiled: February 19, 2014Date of Patent: November 5, 2019Assignee: Reuter Chemische Apparatebau KGInventors: Karl Reuter, Tobias Wedel, Viktor Meier, Mark Kantor, Vasyl Andrushko, Florian Stolz
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Publication number: 20160251311Abstract: The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, and in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrate and crystalline (S)-3-aminopiperidine-di-hydrochloride-monohydrate.Type: ApplicationFiled: February 19, 2014Publication date: September 1, 2016Applicant: REUTER CHEMISCHE APPARATEBAU KGInventors: Karl Reuter, Tobias Wedel, Viktor Meier, Mark Kantor, Vasyl Andrushko, Florian Stolz
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Publication number: 20160068486Abstract: The present invention relates to a process for preparing enantiomerically enriched 3-hydroxymethylpiperidine and in particular of the S-enantiomer of (S)-3-hydroxymethyl-piperidine in high chemical and optical purity. The invention also relates to extremely pure (S)-3-hydroxymethylpiperidine and (R)-3-hydroxymethylpiperidine.Type: ApplicationFiled: April 22, 2014Publication date: March 10, 2016Applicant: REUTER CHEMISCHE APPARATEBAU KGInventors: Karl Reuter, Tobias Wedel, Vasyl Andrushko, Christian Wiegand, Florian Stolz
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Patent number: 6855176Abstract: A method for purifying substances through emulsion crystallisation is described, whereby (a) an emulsion of organic liquid droplets in a continuous water phase containing the impure substance is formed; (b) the emulsion is super-saturated in the substance; (c) crystallisation of the substance in the water phase is induced; (d) the crystals of the substance are isolated from the from emulsion, yielding an emulsion-filtrate; (e) additional impure substance is dissolved in the emulsion-filtrate; and (f) steps (b)-(d) are repeated with the emulsion obtained from step (e).Type: GrantFiled: March 8, 2000Date of Patent: February 15, 2005Assignee: Reuter Chemische Apparatebau KG [DE/DE]Inventor: Karl Reuter
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Patent number: 6570036Abstract: A process for isolating one or more enantiomer components from a mixture of enantiomers through co-crystallization is disclosed.Type: GrantFiled: August 31, 2001Date of Patent: May 27, 2003Assignee: Reuter Chemische Apparatebau KG [DE/DE]Inventor: Karl Reuter
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Patent number: 6428583Abstract: A crystallization process is described for separating a desired substance from an aggregate mixture in which an emulsion of droplets in a continuous phase containing the aggregate mixture is formed and supersaturated, characterized in that the emulsion is seeded with seed crystals of the desired substance and seed crystals of at least one other substance in the aggregate mixture to effect crystallization of the desired substance and the other substance(s) in the continuous phase. Also described are substances separated by the process, and devices for carrying out the process.Type: GrantFiled: April 27, 2000Date of Patent: August 6, 2002Assignee: Reuter Chemische Apparatebau KGInventor: Karl Reuter