Patents Assigned to Reva Medical, Inc.
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Patent number: 10717810Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.Type: GrantFiled: June 12, 2019Date of Patent: July 21, 2020Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, REVA MEDICAL, INC.Inventors: Durgadas Bolikal, Joachim B. Kohn, Lioubov Kabalnova
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Patent number: 10329379Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogs, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.Type: GrantFiled: August 7, 2014Date of Patent: June 25, 2019Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, REVA MEDICAL, INC.Inventors: Durgadas Bolikal, Joachim B. Kohn, Lioubov Kabalnova
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Patent number: 10143493Abstract: Various polymeric materials and delivery systems are described, along with systems and methods for using them for bone and tissue augmentation, such as for the stabilization and/or correction of spinal compression fractures.Type: GrantFiled: June 27, 2016Date of Patent: December 4, 2018Assignee: Reva Medical, Inc.Inventors: Moni Stein, Donald K. Brandom, Lioubov Kabalnova, Steve Howard, Robert F. Dennis
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Patent number: 9782523Abstract: Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.Type: GrantFiled: May 5, 2011Date of Patent: October 10, 2017Assignee: Reva Medical, Inc.Inventors: Donald K. Brandom, James E. McGrath, Joan Zeltinger, Eric V. Schmid, Robert K. Schultz
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Patent number: 9452068Abstract: An expandable slide and lock stent comprises a tubular member that can be expanded from a collapsed state to an expanded state. The tubular member can comprise a reversing helical backbone and at least one rail member extending from the helical backbone in a circumferential direction. The backbone can have at least one engagement element that can be configured to receive a rail member to form the tubular member. In some embodiments, the reversing helical backbone can comprise a plurality of discrete segments having a variable profile and/or wave form.Type: GrantFiled: August 28, 2013Date of Patent: September 27, 2016Assignee: REVA Medical, Inc.Inventors: Eric Schmid, Keith Weier, Keith A. Esser, Steven C. Howard, John Hobson, Craig Bonsignore
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Patent number: 9408732Abstract: An expandable slide and lock stent comprises a tubular member that can be expanded from a collapsed state to an expanded state. The tubular member can comprise a reversing helical backbone and at least one rail member extending from the helical backbone in a circumferential direction. The backbone can have at least one engagement element that can be configured to receive a rail member to form the tubular member. In some embodiments, the reversing helical backbone can comprise a plurality of discrete segments having a variable profile and/or wave form. A plurality of regions of each backbone may have a recessed or “nesting” profile providing for a smaller overall stent profile in a compacted configuration, and improved stent retention as mounted on a balloon catheter.Type: GrantFiled: March 11, 2014Date of Patent: August 9, 2016Assignee: REVA Medical, Inc.Inventors: Keith Weier, Steven C. Howard
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Patent number: 9402859Abstract: Various polymeric materials and delivery systems are described, along with systems and methods for using them for bone and tissue augmentation, such as for the stabilization and/or correction of spinal compression fractures.Type: GrantFiled: February 4, 2014Date of Patent: August 2, 2016Assignee: REVA Medical, Inc.Inventors: Moni Stein, Donald K. Brandom, Lioubov Kabalnova, Steve Howard, Robert F. Dennis
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Patent number: 9314354Abstract: Expandable medical implants for maintaining support of a body lumen are disclosed. These implants comprise an axially-radially nested, diametrically expandable, moveable vascular device for enlarging an occluded portion of a vessel. The device can be configured to allow for motion such as translating and/or slide and lock. One advantage of the axially-radially nested stent is that it maintains the expanded size, without significant recoil.Type: GrantFiled: May 10, 2013Date of Patent: April 19, 2016Assignee: Reva Medical, Inc.Inventors: Andrew Morris, Jeffrey T. Sheriff, Keith Esser
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Patent number: 9173751Abstract: The invention relates to an expandable stent comprising circumferentially adjacent modules. The modules comprise longitudinally adjacent slide-and-lock radial elements which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.Type: GrantFiled: September 13, 2012Date of Patent: November 3, 2015Assignee: REVA MEDICAL, INC.Inventors: Eric V. Schmid, John D. Nguyen, Steven C. Howard, Orlando M. Padilla, Andrew Morris, Robert F. Eisele, Daniel Moore, Thomas R. Jackson, Joan Zeltinger
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Patent number: 9149378Abstract: The inventions relate generally to expandable medical implants for maintaining support of a body lumen and, in particular, to an axially nested, diametrically expandable, slide and lock vascular device for enlarging an occluded portion of a vessel. The axially nested vascular device desirably achieves both competitive crossing profiles while maintaining other key features, such as, for example, radial strength and luminal patency. The collapsed profile can also be made very thin without compromising radial strength. Thus, the vascular device can advantageously be deployed in small and difficult to reach areas or vessels. The axial nesting substantially eliminates radial overlap between mating structural elements thereby desirably allowing for a low, uniform profile.Type: GrantFiled: August 18, 2008Date of Patent: October 6, 2015Assignee: REVA MEDICAL, INC.Inventors: Andrew Morris, Eric Schmid, Jeffrey Sheriff, Brandon Felkins
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Patent number: 9066827Abstract: An expandable slide and lock stent is provided that comprises a plurality of radial elements interconnected to form a tubular member. Each radial element can comprise a helical backbone and at least one elongate member extending from the helical backbone in a circumferential direction. Each backbone can have at least one slot that can be configured to receive an elongate member of an adjacent radial element.Type: GrantFiled: September 4, 2013Date of Patent: June 30, 2015Assignee: REVA Medical, Inc.Inventors: Eric Schmid, Andrew Morris, Keith Weier, Craig Bonsignore, Keith Esser, Steven C. Howard, Joseph A. DiPari
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Publication number: 20140277375Abstract: An expandable slide and lock stent comprises a tubular member that can be expanded from a collapsed state to an expanded state. The tubular member can comprise a reversing helical backbone and at least one rail member extending from the helical backbone in a circumferential direction. The backbone can have at least one engagement element that can be configured to receive a rail member to form the tubular member. In some embodiments, the reversing helical backbone can comprise a plurality of discrete segments having a variable profile and/or wave form. A plurality of regions of each backbone may have a recessed or “nesting” profile providing for a smaller overall stent profile in a compacted configuration, and improved stent retention as mounted on a balloon catheter.Type: ApplicationFiled: March 11, 2014Publication date: September 18, 2014Applicant: REVA Medical, Inc.Inventors: Keith Weier, Steven C. Howard
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Patent number: 8702716Abstract: Various polymeric materials and delivery systems are described, along with systems and methods for using them for bone and tissue augmentation, such as for the stabilization and/or correction of spinal compression fractures.Type: GrantFiled: September 20, 2010Date of Patent: April 22, 2014Assignee: REVA Medical Inc.Inventors: Moni Stein, Don Brandom, Lioubov Kabalnova, Steve Howard, Robert F. Dennis
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Patent number: 8703113Abstract: Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.Type: GrantFiled: January 18, 2006Date of Patent: April 22, 2014Assignee: REVA Medical Inc.Inventors: Donald K. Brandom, James E. McGrath, Joan Zeltinger, Eric V. Schmid, Robert K. Schultz
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Publication number: 20140094897Abstract: An expandable slide and lock stent is provided that comprises a plurality of radial elements interconnected to form a tubular member. Each radial element can comprise a helical backbone and at least one elongate member extending from the helical backbone in a circumferential direction. Each backbone can have at least one slot that can be configured to receive an elongate member of an adjacent radial element.Type: ApplicationFiled: September 4, 2013Publication date: April 3, 2014Applicant: REVA Medical, Inc.Inventors: Eric Schmid, Andrew Morris, Keith Weier, Craig Bonsignore, Keith Esser, Steven C. Howard, Josepth A. DiPari
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Publication number: 20140025159Abstract: Expandable medical implants for maintaining support of a body lumen are disclosed. These implants comprise an axially-radially nested, diametrically expandable, moveable vascular device for enlarging an occluded portion of a vessel. The device can be configured to allow for motion such as translating and/or slide and lock. One advantage of the axially-radially nested stent is that it maintains the expanded size, without significant recoil.Type: ApplicationFiled: May 10, 2013Publication date: January 23, 2014Applicant: Reva Medical, Inc.Inventors: Andrew Morris, Jeffrey T. Sheriff, Keith Esser
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Patent number: 8617235Abstract: The invention relates generally to expandable medical implants for maintaining support of a body lumen and, in particular, to an axially nested, diametrically expandable, slide and lock vascular device for enlarging an occluded portion of a vessel. The axially nested vascular device desirably achieves both competitive crossing profiles while maintaining other key features, such as, for example, radial strength and luminal patency. The collapsed profile can also be made very thin without compromising radial strength. Thus, the vascular device can advantageously be deployed in small and difficult to reach areas or vessels. The axial nesting substantially eliminates radial overlap between mating structural elements thereby desirably allowing for a low, uniform profile.Type: GrantFiled: March 28, 2011Date of Patent: December 31, 2013Assignee: REVA Medical, Inc.Inventors: Eric V. Schmid, John D. Nguyen, Orlando Padilla, Andrew Morris, Daniel Moore, Thomas R. Jackson
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Patent number: 8545547Abstract: An expandable slide and lock stent is provided that comprises a plurality of radial elements interconnected to form a tubular member. Each radial element can comprise a helical backbone and at least one elongate member extending from the helical backbone in a circumferential direction. Each backbone can have at least one slot that can be configured to receive an elongate member of an adjacent radial element.Type: GrantFiled: May 23, 2011Date of Patent: October 1, 2013Assignee: Reva Medical Inc.Inventors: Eric Schmid, Andrew Morris, Keith Weier, Craig Bonsignore, Keith Esser, Steven C. Howard, Joseph A. DiPari
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Publication number: 20130253631Abstract: The invention relates to an expandable stent comprising circumferentially adjacent modules. The modules comprise longitudinally adjacent slide-and-lock radial elements which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.Type: ApplicationFiled: September 13, 2012Publication date: September 26, 2013Applicant: REVA MEDICAL, INC.Inventors: Eric V. Schmid, John D. Nguyen, Steven C. Howard, Orlando M. Padilla, Andrew Morris, Robert F. Eisele, Joseph Anthony DiPari, David G. Matsuura, Philip J. Simpson, Walter D. Gillespie, Daniel Moore, Thomas R. Jackson, Joan Zeltinger, Keith Allen Esser, Donald K. Brandom
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Patent number: 8540762Abstract: Expandable medical implants for maintaining support of a body lumen are disclosed. Some embodiments of these implants comprise a circumferentially nested, diametrically expandable, moveable vascular device for enlarging an occluded portion of a vessel. The device can be configured to allow for motion such as rotating, translating, and/or slide and lock.Type: GrantFiled: May 7, 2012Date of Patent: September 24, 2013Assignee: REVA Medical, Inc.Inventors: Eric Schmid, Andrew Morris, Orlando Padilla