Abstract: Methods and devices are provided for switching fluid flow through a body part, such as all or portions of an organ or extremity. In general, fluid inflow and fluid outflow vessels to at least a portion of a body part can be switched such that all fluid in at least a portion of the inflow and outflow vessels flows in an opposite direction. In other words, the fluid inflow vessel (or at least a portion thereof) becomes the fluid outflow vessel that receives fluid from a body part, and the fluid outflow vessel (or at least a portion thereof) becomes the fluid inflow vessel that delivers fluid to a body part.