Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: The present disclosure relates to methods for the treatment of diseases or disorders (e.g., cancer) with mTOR inhibitors. Specifically, the disclosure relates to methods of treating a subject having a cancer by administering a particular dosage of an mTOR inhibitor. In some embodiments this disclosure includes methods for delaying, preventing, or treating acquired resistance to RAS inhibitors using a dosage of an mTOR inhibitor. In some embodiments, this disclosure relates to methods of treating or preventing adverse events associated with administration of an mTOR inhibitor using tacrolimus.

Abstract: The present invention relates to a process of manufacturing skiing equipment using a high-entropy alloy, especially manufacturing for a bottom member of a ski, a blade of an ice skate shoe or the bottom member of a skiing vehicle. The high-entropy alloy is used to prepare skiing equipment, so that the skiing equipment has a small friction coefficient, obtains good speed, and can be driven with less energy, which realizes energy-saving effect.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: Software creation platforms are disclosed, including platforms which provide to users templates and text-based prompts for filling out the provided templates and creating games that incorporate non-fungible token technology. Also disclosed are methods of creating software, such as video games, using the disclosed platform.

Abstract: A system configured to receive health data pertaining to a user; select a user health profile from a plurality of user health profiles based on the collected health data, each of the plurality of user health profiles being associated with a health and wellness program and a set of interventions; receive user activity data and updated health data pertaining to, or during the user's participation in the associated health and wellness program from health devices; select a new set of interventions based on the user activity data; and select a new user health profile from the plurality of user health profiles based on at least one of the user activity data and the updated health data.

Abstract: The present disclosure is directed to compounds of Formula IV: as inhibitors of SHP2 and their use in the treatment of diseases associated with SHP2. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: A zinc-air battery cell assembly comprising: a layer of anode material; one or more layers of cathode material; a separator directly between and engaging both the layer of anode material and the layer of cathode material that acts as both an electronic insulator and an ion conductive path between the layer of anode material and the layer of cathode material; and a diffusion member directly engaging the layer of cathode material.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2, such as pyrazine compounds, and their use in the treatment of disease associated with SHP2 modulation, such as Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: A zinc-air battery cell assembly comprising: a cathode can that includes: a planar base, and an elongated cathode sidewall that extends to a terminal cathode sidewall end, and an anode can that includes: a planar top end, and an elongated anode sidewall that extends to a terminal anode sidewall end, the anode can disposed nested within the cathode can with the elongated anode sidewall disposed parallel and adjacent to the elongated cathode sidewall. The zinc-air battery assembly further includes a cavity defined by the cathode can and the anode can disposed nested within the cathode can, and a grommet that provides a seal between the cathode can and the anode can while also keeping the anode can and the cathode can separate.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: A power generation system includes one or more micro-turbine electric generators (“MTEGs”). The MTEGs include a housing having an inlet for receiving pressurized gas and an outlet for releasing expanded gas. The MTEGs also include a rotor, a user-replaceable nozzle for directing pressurized gas over blades of the rotor, and a stator for generating alternating current (“AC”) responsive to rotation of the rotor. The power generation system also includes a programmable logic controller (“PLC”) coupled to the MTEGs that operates flow control valves (“FCVs”) coupled to the MTEGs to modulate the flow of gas to the MTEGs to generate output power suitable to support an electrical load. The system also includes power conversion circuitry configured to convert AC generated by the MTEGs to direct current (“DC”) and to provide the DC to an electrical load. The system also includes a skid for mounting multiple and MTEGs and FCVs.

Abstract: A system configured to receive health data pertaining to a user; select a user health profile from a plurality of user health profiles based on the collected health data, each of the plurality of user health profiles being associated with a health and wellness program and a set of interventions; receive user activity data and updated health data pertaining to, or during the user's participation in the associated health and wellness program from health devices; select a new set of interventions based on the user activity data; and select a new user health profile from the plurality of user health profiles based on at least one of the user activity data and the updated health data.

Abstract: The invention relates to a cooling system for a mould, in particular a mould for vertical continuous casting, comprising at least one cooling unit (11), wherein the mould has a running surface (10) with an inner side and an outer side and the inner side of the running surface (10a) limits a continuous casting during operation, wherein the cooling unit (11) is designed to be moveably arranged on the mould and the cooling unit (11) has an adjusting element (13), wherein the cooling unit (11) is arranged on the mould in such a way that a gap (12) is formed between the cooling unit (11) and the outer side of the running surface (10) and the width of the gap (12) can be adjusted by the adjusting element (13).

Abstract: A balance board system, comprising, a rotatable roller, a balance board having a lower surface that sits atop the rotatable roller and reciprocally rides on the rotatable roller, the balance board lower surface having a plurality of attachment points, a plurality of board connectors disposed at the plurality of attachment points, a plurality of stop connectors and a plurality of roller stops coupled to at least two of the plurality of stop connectors, the plurality of roller stops are attachable to the balance board at a respective one of the plurality of attachment points.