Patents Assigned to Rexahn Pharmaceuticals, Inc.
  • QUINOXALINYL-PIPERAZINAMIDE METHODS OF USE
    Publication number: 20200231553
    Abstract: The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 21, 2020
    Publication date: July 23, 2020
    Applicant: REXAHN PHARMACEUTICALS, INC.
    Inventors: Deog Joong Kim, Young Bok Lee, Reza Mazhari, Daniel Edward Emrich
  • Quinoxalinyl-piperazinamide methods of use
    Patent number: 10570101
    Abstract: The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: February 25, 2020
    Assignee: REXAHN PHARMACEUTICALS, INC.
    Inventors: Deog Joong Kim, Young Bok Lee, Reza Mazhari, Daniel Edward Emrich
  • FLUOROCYCLOPENTENYLCYTOSINE METHODS OF USE
    Publication number: 20190275042
    Abstract: The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof. The disclosed subject matter further provides a method of treating one or more symptoms of cancer comprising administering to a subject in need thereof a compound of formula (I) and a process for preparing such.
    Type: Application
    Filed: March 18, 2019
    Publication date: September 12, 2019
    Applicant: Rexahn Pharmaceuticals, Inc.
    Inventors: Young Bok Lee, Deog Joong Kim, Godefridus J. Peters, Reza Mazhari, Dzjemma Sarkisjan
  • Fluorocyclopentenylcytosine methods of use
    Patent number: 10278971
    Abstract: The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof. The disclosed subject matter further provides a method of treating one or more symptoms of cancer comprising administering to a subject in need thereof a compound of formula (I) and a process for preparing such.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: May 7, 2019
    Assignee: REXAHN PHARMACEUTICALS, INC.
    Inventors: Young Bok Lee, Deog Joong Kim, Godefridus J. Peters, Reza Mazhari, Dzjemma Sarkisjan
  • QUINOXALINYL-PIPERAZINAMIDE METHODS OF USE
    Publication number: 20180290985
    Abstract: The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 11, 2018
    Applicant: REXAHN PHARMACEUTICALS, INC.
    Inventors: Deog Joong Kim, Young Bok Lee, Reza Mazhari, Daniel Edward Emrich
  • Nanoparticulate compositions and formulations of piperazine compounds
    Patent number: 10052321
    Abstract: The present invention relates to storage stable nanoparticulate compositions of piperazine compounds. The pharmaceutical compositions comprising the nanoparticulate compositions that are useful for the treatment and prevention of proliferative diseases including cancer are also described.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: August 21, 2018
    Assignee: REXAHN PHARMACEUTICALS, INC.
    Inventors: Young Bok Lee, Chang-Ho Ahn, Deog Joong Kim
  • Quinoxalinyl-piperazinamide methods of use
    Patent number: 9969698
    Abstract: The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: May 15, 2018
    Assignee: REXAHN PHARMACEUTICALS, INC.
    Inventors: Deog Joong Kim, Young Bok Lee, Reza Mazhari, Daniel Edward Emrich
  • Process for the preparation of 4-amino 1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one
    Patent number: 9920016
    Abstract: Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3 -hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one(13, RX-3117) and its intermediates are described.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 20, 2018
    Assignee: REXAHN PHARMACEUTICALS, INC.
    Inventors: Deog Joong Kim, Haifeng Yin, Eliezer Falb, Leigh Andre Pearcey, Jonathan Cummins, Petra Dieterich, Jean-Francois Carniaux, Yi Wang, Vikram Chandrakant Purohit
  • FLUOROCYCLOPENTENYLCYTOSINE METHODS OF USE
    Publication number: 20180021338
    Abstract: The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof. The disclosed subject matter further provides a method of treating one or more symptoms of cancer comprising administering to a subject in need thereof a compound of formula (I) and a process for preparing such.
    Type: Application
    Filed: August 22, 2017
    Publication date: January 25, 2018
    Applicant: Rexahn Pharmaceuticals, Inc.
    Inventors: Young Bok Lee, Deog Joong Kim, Godefridus J. Peters, Reza Mazhari, Dzjemma Sarkisjan
  • NANOPARTICULATE COMPOSITIONS AND FORMULATIONS OF PIPERAZINE COMPOUNDS
    Publication number: 20180008601
    Abstract: The present invention relates to storage stable nanoparticulate compositions of piperazine compounds. The pharmaceutical compositions comprising the nanoparticulate compositions that are useful for the treatment and prevention of proliferative diseases including cancer are also described.
    Type: Application
    Filed: July 26, 2017
    Publication date: January 11, 2018
    Applicant: Rexahn Pharmaceuticals, Inc.
    Inventors: Young Bok Lee, Chang-Ho Ahn, Deog Joong Kim
  • Fluorocyclopentenylcytosine methods of use
    Patent number: 9782410
    Abstract: The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof. The disclosed subject matter further provides a method of treating one or more symptoms of cancer comprising administering to a subject in need thereof a compound of formula (I) and a process for preparing such.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: October 10, 2017
    Assignee: REXAHN PHARMACEUTICALS, INC.
    Inventors: Young B. Lee, Deog J. Kim, Reza Mazhari, Godefridus J. Peters, Dzjemma Sarkisjan
  • Nanoparticulate compositions and formulations of piperazine compounds
    Patent number: 9744167
    Abstract: The present invention relates to storage stable nanoparticulate compositions of piperazine compounds. The pharmaceutical compositions comprising the nanoparticulate compositions that are useful for the treatment and prevention of proliferative diseases including cancer are also described.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: August 29, 2017
    Assignee: Rexahn Pharmaceuticals, Inc.
    Inventors: Young B. Lee, Chang-Ho Ahn, Deog J. Kim
  • Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds
    Patent number: 9713615
    Abstract: Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone derivatives represented by formula (I), pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for treating hyperproliferative disorders by administering the compounds are also described. 1,2,3,4-tetrahydroisoquinoline derivatives for making tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds are also described.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: July 25, 2017
    Assignee: Rexahn Pharmaceuticals, Inc.
    Inventors: Young Bok Lee, Jae Min Kim, Deog Joong Kim, Chang-Ho Ahn
  • Process for the Preparation of 4-Amino-1-((1S,4R,5S)-2-Fluoro-4,5-Dihydroxy-3-Hydroxymethyl-Cyclopent-2-Enyl)-1H-Pyrimidin-2-One
    Publication number: 20170158662
    Abstract: Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one (13, RX-3117) and its intermediates are described.
    Type: Application
    Filed: December 15, 2016
    Publication date: June 8, 2017
    Applicant: Rexahn Pharmaceuticals, Inc.
    Inventors: Deog Joong Kim, Haifeng Yin, Eliezer Falb, Leigh Andre Pearcey, Jonathan Cummins, Petra Dieterich, Jean-Francois Carniaux, Yi Wang, Vikram Chandrakant Purohit
  • QUINOXALINYL-PIPERAZINAMIDE METHODS OF USE
    Publication number: 20170066726
    Abstract: The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 2, 2016
    Publication date: March 9, 2017
    Applicant: REXAHN PHARMACEUTICALS, INC.
    Inventors: Deog Joong Kim, Young Bok Lee, Reza Mazhari, Daniel Edward Emrich
  • FLUOROCYCLOPENTENYLCYTOSINE METHODS OF USE
    Publication number: 20170014411
    Abstract: The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof. The disclosed subject matter further provides a method of treating one or more symptoms of cancer comprising administering to a subject in need thereof a compound of formula (I) and a process for preparing such.
    Type: Application
    Filed: June 9, 2016
    Publication date: January 19, 2017
    Applicant: Rexahn Pharmaceuticals, Inc.
    Inventors: Young Bok Lee, Deog Joong Kim, Reza Mazhari, Godefridus J. Peters, Dzjemma Sarkisjan
  • Process or the preparation of 4-amino 1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-Enyl)-1H-pyrimidin-2-one
    Patent number: 9533958
    Abstract: Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one (13, RX-3117) and its intermediates are described.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: January 3, 2017
    Assignee: Rexahn Pharmaceuticals, Inc.
    Inventors: Haifeng Yin, Deog Joong Kim, Eliezer Falb, Leigh Andre Pearcey, Jonathan Cummins, Petra Dieterich, Jean-Francois Carniaux, Yi Wang, Vikram Chandrakant Purohit
  • HPMA—docetaxel conjugates and uses therefore
    Patent number: 9434610
    Abstract: Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: September 6, 2016
    Assignees: REXAHN PHARMACEUTICALS, INC., University of Maryland, Baltimore
    Inventors: Young B. Lee, Deog J. Kim, Chang H. Ahn, Anjan Nan, Hamidreza Ghandehari, Abhijit Ray
  • Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds
    Patent number: 9193707
    Abstract: Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone derivatives represented by formula (I), pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for treating hyperproliferative disorders by administering the compounds are also described. 1,2,3,4-tetrahydroisoquinoline derivatives for making tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds are also described.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 24, 2015
    Assignee: Rexahn Pharmaceuticals, Inc.
    Inventors: Young Bok Lee, Jae Min Kim, Deog Joong Kim, Chang-Ho Ahn
  • Process for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one
    Patent number: 9150520
    Abstract: Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one (13, RX-3117) and its intermediates are described.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: October 6, 2015
    Assignee: Rexahn Pharmaceuticals, Inc.
    Inventors: Haifeng Yin, Deog J. Kim, Eliezer Falb, Leigh A. Pearcey, Jonathan Cummins, Petra Dieterich, Jean-Francois Carniaux, Yi Wang, Vikram Chandrakant Purohit