Abstract: The present invention relates to compositions and manufacturing methods of topical adapalene preparations, which include a solvent-lipid complex in order to keep the active pharmaceutical ingredient dissolved in a vehicle whose external or continuous phase is aqueous. Thus, a pleasant non-oily sensation is achieved at the moment of application, while greater retention of the active pharmaceutical ingredient is reached in targeted skin layers, thereby reducing systemic uptake in the blood.
Type:
Grant
Filed:
March 14, 2017
Date of Patent:
June 5, 2018
Assignee:
Rey Ventures, LLC
Inventors:
Julio César Villamil Torres, Camilo Rey Ferro