Abstract: A polymer composition useful for controlling the formation, growth and/or agglomeration of clathrate hydrate comprising two different polymers, designated Polymer x and Polymer y respectively, characterized in that Polymer x is a material whose In(WBF) is greater than that of Polymer y, which satisfy the following conditions: a) In(WBF) of x-In(WBF) of y is greater than 3 and b) the Synergism Index is greater than 0.05.