Abstract: Systems and methods for monitoring subdermal fluid are disclosed. The subdermal fluid monitoring system may include a flexible substrate, at least six temperature sensors and at least three thermal actuators supported by the flexible substrate, an adhesive substrate, a power source configured to supply power to the at least six temperature sensors and to the at least three thermal actuators; a memory storage device; and a microprocessor in communication with the memory storage device. The microprocessor may be configured to activate the power source to supply power to at least one thermal actuator to cause heating of a subdermal fluid, receive information associated with a temperature of the subdermal fluid from at least one temperature sensor; calculate an alert condition based on a set of instructions received from a memory storage device and the temperature of the subdermal fluid; and trigger an alert if the alert condition is met.