Abstract: A wrist endoprosthesis (2) for functional replacement of the human wrist, containing a radius component (4) that has a shaft (10) for anchoring in the radius, a head (12), and a first joint surface (16), which is implemented on a distal head face (14), and a carpal component (6) that has a proximal carpal face (22), a distal carpal face (20) and a second joint surface (24) which is formed on the proximal carpal face (22) and interacts with the first joint surface (169) of the radius component (4), characterized in that the carpal component (6) is substantially trough-shaped, in order to at least partially surround the carpal bones. Also, a wrist endoprosthesis (2) that has anti-luxation protection (8), a method for producing wrist endoprostheses (2) and a computer program product.

Abstract: A hearing aid for compensating for an occlusion effect while emitting an acoustic useful signal into an auditory canal of a human ear comprises an earbud that can be inserted into the auditory canal, a speaker for emitting a compensation signal into the auditory canal, a microphone for receiving an error signal from the auditory canal, and a control unit for processing a recorded signal to be emitted. The controller is designed by measuring a nominal secondary path between a speaker and the microphone and determining a transmission function that describes behavior of the nominal secondary path, determining a first requirement as a tolerance band about the transmission function, determining a second requirement as a desired sensitivity function of the hearing aid, designing the controller using an optimization method while simultaneously taking the first and second requirements into consideration, and implementing the controller in the control unit.

Abstract: Complexes suitable for targeting and killing a human target cell comprising a first polypeptide with a binding structure for binding the complex to the cellular surface receptor CD89 (e.g. with an anti CD89 antibody) presented on the cell surface of the human target cell and a second polypeptide comprising a toxic effector domain, preferably Pseudomonas exotoxin A); to nucleic acid molecules encoding said complexes, vectors, host cells containing the nucleic acids and methods for preparation and producing such complexes; compositions and methods for using said complexes for the treatment of diseases, in particular of cancer diseases like leukemia.

Abstract: The invention relates to a rotary piston pump, in particular for pumping blood, comprising a piston rotor (1) which has particularly two or three faces when seen in cross-section, which is mounted in a piston chamber (2) and eccentrically rotates, the piston rotor (1) having in its interior a plurality of magnetically interacting elements (4, 4a, 4b), in particular permanent magnets and/or coils, and being driven by the magnetic interaction of these elements (4, 4a, 4b) with at least one moving magnetic field.

Abstract: A superstructure for thermal desalination is optimized by controlling various parameters, wherein the variable parameters include a feed routing for flow of a liquid feed; brine routings for flow of concentrated brine from the liquid feed; vapor routings for vapor generated from the liquid feed; a series of multi-effect distillation effects, each of the effects coupled with at least one routing selected from the feed routing and the brine routings and with one of the vapor routings; and a series of multi-stage flash stages coupled with at least one routing selected from the feed routing and the brine routings and with one of the vapor routings. The superstructure may or may not contain a thermal vapor compressor.

Abstract: The technology provided herein relates to novel isolated polypeptides and peptides having a growth inhibitory effect on human cancer cells. Nucleic acid molecules encoding said polypeptides/peptides, vectors, host cells containing the nucleic acids and methods for preparation and producing said polypeptides/peptides. Compositions and methods for using such polypeptides/peptides for the prevention and treatment of cancer are also encompassed by the present disclosure.

Abstract: The invention relates to a device for performing respiratory training, in particular altitude training, comprising a mouthpiece (1) through which a person can exhale respiratory gas into a volume (2, 3a, 7) or can inhale it out of the volume (2, 3a, 7), wherein this volume (2, 3a, 7) is formed at least in part by a container (2) which is adjustable in terms of its volume and which is connected to the mouthpiece, wherein the volume (2, 3a, 7) adjoins one side of at least one gas-permeable membrane (4), to the other side of which at least one gas exchange chamber (3b) is connected, through which a fluid provided for the gas exchange, in particular CO2 and/or O2 gas exchange, can actively flow.

Abstract: The present invention relates to kits comprising plus-sense single stranded RNA viral vectors, as well as mixtures of these vectors and uses thereof, and methods for producing in a plant, or plant tissue, or plant cell simultaneously two or more polypeptides using the kits and vectors.

Abstract: The invention relates to a system for monitoring a substratum (1) with regard to damage and/or for protecting a substratum (1) from damage. The system comprises: an electrolytically active layer (4), which has a moisture-dependent electrical resistance; at least one electrode pair, the spaced-apart electrodes (3a, 3b) of which are connected to each other by means of the electrolytically active layer (4); and a measuring device, by means of which a property, in particular an electrical quantity of the electrolytically active layer (4) or of the electrodes (3a, 3b), can be measured by using electrodes (3a, 3b) of at least one electrode pair, in particular of each electrode pair, and/or a control device, by means of which a voltage can be applied to the electrodes (3a, 3b) of at least one electrode pair, in particular of each electrode pair.

Abstract: The present invention relates to a method for determining the propensity of a fluid for calcification.

Abstract: A compound comprising a photosensitizer covalently coupled to a protein selected from the group consisting of antibodies or their derivatives or fragments thereof, synthetic peptides such as scFv, mimotopes which bind CD antigens, cytokine receptors, interleukin receptors, hormone receptors, growth factor receptors, more particularly tyrosine kinase growth factor receptor of the ErbB family, wherein the photosensitizer is coupled to the binding protein via O6-alkylguanine-DNA alkyltransferase (hAGTm), a modified human DNA repair protein.

Abstract: The present invention relates to a method for determining the propensity of a fluid for calcification.

Abstract: A method for producing a bonded joint between a light metal of a first component and a steel material of a second component, wherein a protective-gas joining process is used, a zinc-based filler material is used, and wherein an arc of the protective-gas joining process reaches at least the steel material of the second component, wherein a phase space of at least intermetallic phase composed of iron and the light metal is produced in a joining region adjacent to the steel material. Introduction of heat occurs so that the joint to the steel material is a solder or brazed connection and, during joining, a detachment of part of the solidified intermetallic phase(s) from the steel material of the second component starts in a melt of a solder or brazed matrix formed by the filler material and the at least one intermetallic phase is embedded in the solder matrix.

Abstract: The invention relates to a liquid column damping system, particularly for damping building vibrations, comprising a tank (B, S1, S2) filled with a liquid, said tank having, in particular, a substantially U-shaped geometry in at least one direction. At least two columns (S1, S2) of the tank arranged at a distance from each other, particularly for forming communicating liquid columns, are connected by a base region (B) of the tank, and means for adjusting the damping of the liquid column damping system and/or the natural frequency of the liquid column damping system are provided. At least one column wall region (W1) in at least one of the columns (S1, S2), preferably in all columns, can be moved in order to change the column cross-section.

Abstract: An axial-flow blood pump has a rotatable impeller assembly rotatable about an axis and itself having a radially projecting blade and permanent magnets, A stationary stator assembly has stator windings interacting with the permanent magnets and a bearing system supporting the rotatable impeller assembly for rotation about the axis relative to the stator assembly. A stent implantable into a blood vessel is connected to ends of supports for coaxially mounting the stator assembly carrying the impeller assembly in the stent.

Abstract: A device and a method is disclosed for detecting an undesired escape of fluids, in that electric potentials are measured using a grid of non-polarizable measuring electrodes above an underground storage facility. Potential differences are determined in such a way that disturbances due to injection borehole or due to the exchange of fluids in the underground storage facility are eliminated. This is done either through the use of the symmetry of the potential distribution around the injection borehole in that the potential differences of pairs of measuring electrodes are observed whose mid-points coincide with the injection borehole or else through the computational simulation of the potentials that arise due to the fluid movement in the underground storage facility without a leak. These are then subtracted from the measured potentials. If the ascertained potential differences exceed a limit value, this is considered as an indication of a leak.

Abstract: The invention relates to a hydraulic coupling bush (1), comprising a bush housing (4), in particular a sleeve-shaped hush housing (4), in which a hush tappet (12), an axially movable compression sleeve (13) that surrounds the hush tappet (12) in an axially parallel manner, in particular coaxially, and an axially movable retaining sleeve (16) that surrounds the compression sleeve (13) in an axially parallel manner, in particular coaxially, are arranged in an axially parallel manner, in particular coaxially, the outer surface of the retaining sleeve supporting or releasing securing elements (18) arranged in the bush housing (4) in the dial direction and the in particular annular end face (16a) of the retaining sleeve lying at least substantially in one plane with the end faces (12a) of the bush tappet (12) and of the bush housing (4) in the decoupled state, wherein the compression sleeve is ex posed from the inside to a hydraulic fluid to be conveyed through the bush at least substantially without applying axia

Abstract: The application relates to a method for determining the cut quality of a laser cutting process, said quality being assessed on the basis of the formation of solidification ridges along the cut face and/or burr formation on the lower edge of the cut face. In said method, a virtual laser cutting machine in a simulation program can be virtually operated with a set of values P0 from a parameter space P.

Abstract: A method for reading out a memory element comprises a series connection. of at least two memory cells A and B each have a stable state A0 or B0 having higher resistance and a stable state A1 or B1 having lower electrical resistance. An electrical variable of the series circuit is measured and an electrical variable is selected for this measurement, to which the memory cell A in state A0 makes a different contribution than the memory cell B in state B0 and/or to which the memory cell A instate A1 makes a different contribution than the memory cell B in state B1. The two state combinations A1 and B0 or A0 and B1 then result in differing values for the electrical variable that is measured by way of the series circuit. These state combinations can thus be distinguished from each other without having to change the logic state of the memory element during reading.

Abstract: The invention relates to a method for determining the location of the corrosion sites in reinforced concrete, wherein a value (UB, UC) of a voltage potential (UB, UC) present at each measurement location is measured at at least two measurement locations relative to a reference voltage potential (UA) present at a reference location, and information about the direction to the corrosion site (K) and/or the distance to the corrosion site (K) is determined from the location information (XB, YB, XC, YC) for each measurement location, particularly also the reference location, and the voltage potential (UA, UB, UC) present at each location.