Patents Assigned to Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
  • Publication number: 20200248265
    Abstract: A method of diagnosing a disease associated with a DNA repeat sequence is disclosed. The method comprises: (a) determining the number of repeats of a DNA sequence in DNA molecules of a sample of the subject; and (b) determining the CpG methylation status of the DNA molecules, wherein the number of repeats of the DNA sequence and the CpG methylation status of the DNA molecules is indicative of the disease.
    Type: Application
    Filed: April 15, 2020
    Publication date: August 6, 2020
    Applicants: Ramot at Tel-Aviv University Ltd., Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
    Inventors: Yuval EBENSTEIN, Elmar WEINHOLD, Assaf GRUNWALD, Tslil GABRIELI
  • Patent number: 10608522
    Abstract: An electrical circuit comprising an n-port m-phase active bridge converter with n?2 and m?1, where each port can be operated as an input or an output port, wherein each of the n ports has m phase legs with multiple active switches with parallel connected snubber or resonant capacitors, whereby the n ports can convert a DC-voltage into an AC voltage, the n ports connected via an m-phase transformer or over m separate transformers each connected to each of the m phase legs of each of the n ports to transfer power between the ports, wherein an auxiliary circuit is connected to the transformers to convert a part of a transformer input voltage and energy via an auxiliary voltage source into a DC mid-point capacitor of a DC-link of at least one of the n-port m-phase active bridge converters to recharge the DC mid-point capacitor.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: March 31, 2020
    Assignee: Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
    Inventors: Rik W. De Doncker, Johannes Voss
  • Patent number: 10434504
    Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: October 8, 2019
    Assignee: RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Jürgen Klankermayer, Walter Leitner, Markus Meuresch
  • Publication number: 20190134618
    Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.
    Type: Application
    Filed: November 27, 2018
    Publication date: May 9, 2019
    Applicant: RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Jürgen KLANKERMAYER, Walter Leitner, Markus Meuresch
  • Patent number: 10279933
    Abstract: The invention relates to an androgynous coupling device (10) for connecting modules, in particular for constructing a spacecraft of modular design, wherein, in order to connect the modules, the coupling device (10) can be coupled to an identically constructed further androgynous coupling device and has a plurality of coupling elements (30, 32). It is provided that the androgynous coupling device (10) has a covering element (18) which covers the coupling elements (30, 32) in a passive state of the coupling device (10), wherein a first of the coupling elements (30) can be moved outwardly through the covering element (18) for active coupling to the identically constructed further coupling device. The invention furthermore relates to a module, in particular a module for constructing a spacecraft of modular design, having at least one such coupling device (10).
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: May 7, 2019
    Assignee: Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
    Inventors: Martin Anand Lakshmanan, Marc André Adomeit, Patric Seefeldt, Viktor Reimer
  • Publication number: 20190091636
    Abstract: The subject of the invention is new membranes in which tailor-made membrane transport proteins (such as e.g. TCDB classified proteins) act as pore-forming proteins (e.g. FhuA) or peptides which act as pores in the membrane. The membranes can preferably be produced both by linking synthesised protein-polymer conjugates and by direct linking of the pore-forming proteins and peptides. Such membranes are distinguished by many outstanding features which existing membranes have not been able to offer to date.
    Type: Application
    Filed: March 1, 2017
    Publication date: March 28, 2019
    Applicants: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Himanshu CHARAN, Ulrich GLEBE, Alexander BÖKER, Murat TUTUS, Ulrich SCHWANEBERG, Leilei ZHU, Marco BOCOLA, Tayebeh MIRZAEIGARAKANI, Julia KINZEL, Deepak ANAND
  • Publication number: 20190017124
    Abstract: The present invention relates in a first aspect to new methods for diagnosing or identifying breast cancer or pre-forms thereof in a subject as well as methods for monitoring the development or progress of breast cancer or pre-forms thereof in a subject and methods for the stratification of the therapeutic regimen of a subject suspected to be afflicted with breast cancer or being at risk of developing breast cancer or pre-forms thereof whereby the level or amount of methylation of at least one of the promoters selected from SPAG6-, PER1- and NKX2-6-gene in a sample of said subject is determined followed by the step of diagnosing or identifying breast cancer or pre-forms thereof based on the level on amount of methylation of the at least one promoter. Further, the present invention relates to the use of a kit in a method according to the present invention.
    Type: Application
    Filed: October 28, 2016
    Publication date: January 17, 2019
    Applicant: RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Edgar DAHL, Vera KLOTEN, Jolein MIJNES
  • Publication number: 20170015443
    Abstract: The invention relates to an androgynous coupling device (10) for connecting modules, in particular for constructing a spacecraft of modular design, wherein, in order to connect the modules, the coupling device (10) can be coupled to an identically constructed further androgynous coupling device and has a plurality of coupling elements (30, 32). It is provided that the androgynous coupling device (10) has a covering element (18) which covers the coupling elements (30, 32) in a passive state of the coupling device (10), wherein a first of the coupling elements (30) can be moved outwardly through the covering element (18) for active coupling to the identically constructed further coupling device. The invention furthermore relates to a module, in particular a module for constructing a spacecraft of modular design, having at least one such coupling device (10).
    Type: Application
    Filed: March 30, 2015
    Publication date: January 19, 2017
    Applicant: Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
    Inventors: Martin Anand Lakshmanan, Marc André Adomeit, Patric Seefeldt, Viktor Reimer