Abstract: The invention is based on the finding of specific surface markers for M1-like (classically activated) and M2-like (alternatively activated) macrophages and provides for a method for the identification, characterization and isolation of M1-like and M2-like macrophages based on the abundance of said surface markers and for means for performing such method.
Type:
Application
Filed:
March 13, 2013
Publication date:
February 26, 2015
Applicants:
BECTON DICKINSON AND COMPANY, RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT-BONN
Abstract: The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.
Type:
Grant
Filed:
December 13, 2011
Date of Patent:
September 30, 2014
Assignees:
Rheinische Friedrich-Wilhelms Universität Bonn, Universität Konstanz
Inventors:
Günter Mayer, Christina Elsbeth Luense, Valentin Wittmann, Magnus S. Schmidt
Abstract: The present invention relates to a method for producing vanillin, which comprises an electrochemical oxidation of an aqueous, lignin-comprising suspension or solution at an anode, wherein the anode used is a silver electrode.
Type:
Grant
Filed:
August 8, 2012
Date of Patent:
August 19, 2014
Assignees:
BASF SE, Rheinische Friedrich-Wilhelms-Universitaet Bonn
Inventors:
Florian Stecker, Itamar Michael Malkowsky, Andreas Fischer, Siegfried R. Waldvogel, Carolin Regenbrecht
Abstract: A method of detecting a peroxidic explosive includes providing a sample which may comprise the peroxidic explosive. A mixture comprising at least one ionic liquid and at least one volatile organic solvent is provided. The sample is taken up in the mixture so as to provide a sample for detection. The sample for detection is analytically detected so as to determine whether it includes the peroxidic explosive.
Abstract: The present invention relates to DNA polymerases with a special mutation which have an enhanced mismatch discrimination, the preparation and use thereof. The thermostable DNA polymerases with this mutation are particularly suitable for diagnostic and molecular-biological methods, e.g., allele-specific PCR.
Abstract: A compound for use in a therapeutic treatment of filariasis or a prophylactic treatment of filariasis of the general formula (1) or at least one of racemates, enantiomers, diastereomers, solvates, hydrates, pharmaceutically acceptable salts, and esters of the general formula (1), a nematicidal composition comprising as an active ingredient a compound according to the general formula (1), and a method for treating filariasis.
Inventors:
Kenneth Michael Pfarr, Achim Hoerauf, Gabriele Maria Koenig, Sabine Specht, Andrea Schiefer, Till Friedrich Schaeberle, Alexander Schmitz, Stefan Kehraus
Abstract: The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.
Type:
Application
Filed:
December 13, 2011
Publication date:
March 6, 2014
Applicants:
UNIVERSITÄT KONSTANZ, RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT BONN
Inventors:
Günter Mayer, Christina Elsbeth Luense, Valentin Wittmann, Magnus S. Schmidt
Abstract: The present invention relates to a method of preparing triphosphate-modified oligonucleotides using a capture tag. The method allows the synthesis and purification of triphosphate-modified oligonucleotides in high yield and purity suitable for pharmaceutical applications.
Abstract: The present invention is related to a method of determining a test compound's ability to modify the biological activity of a GPR17. Said method comprises, among others, the step of contacting the test compound with a GPR17, or a functional GPR17 fragment in the presence of a suitable amount of a GPR17 agonist of formula I.
Abstract: The present invention is related to a method of determining a test compound's ability to modify the biological activity of a GPR17. Said method comprises, among others, the step of contacting the test compound with a GPR17, or a functional GPR17 fragment in the presence of a suitable amount of a GPR17 agonist of formula I.
Abstract: The present invention provides a method of using a neutral ionic liquid to at least one of stabilize a peroxidic explosive and to produce a stable solution of the peroxidic explosive which includes providing the neutral ionic liquid and using the neutral ionic liquid to at least one of stabilize the peroxidic explosive and to produce the stable solution of the peroxidic explosive. The present invention further provides a stable composition which includes a solution of at least one neutral ionic liquid and a detectable amount of a peroxidic explosive, a method of production thereof, and a method of use thereof as an odor sample.
Abstract: A method of using peripheral blood monocytes of a patient to at least one of diagnose and assess a risk of a patient of developing Parkinson's disease includes obtaining peripheral blood monocytes from the patient, and determining a methylation pattern of the SNCA(?926/?483) region of the SNCA gene of the DNA of the peripheral blood monocytes.
Abstract: The present invention relates to phenyl diamides according to the general formula (1) and their use as a medicament and a pharmaceutical preparation comprising as an active ingredient a phenyl diamide according to the general formula (1). Further, the present invention relates to phenyl diamides according to the formulas (16), (17) and (18) for use in the treatment of gliomas.
Abstract: The present invention is related to a method of determining a test compound's ability to modify the biological activity of a GPR17. Said method comprises, among others, the step of contacting the test compound with a GPR17, or a functional GPR17 fragment in the presence of a suitable amount of a GPR17 agonist of formula I.
Abstract: A method of detecting a peroxidic explosive includes providing a sample which may comprise the peroxidic explosive. A mixture comprising at least one ionic liquid and at least one volatile organic solvent is provided. The sample is taken up in the mixture so as to provide a sample for detection. The sample for detection is analytically detected so as to determine whether it includes the peroxidic explosive.
Abstract: The present invention relates to a method for producing vanillin, which comprises an electrochemical oxidation of an aqueous, lignin-comprising suspension or solution at an anode, wherein the anode used is a silver electrode.
Type:
Application
Filed:
August 8, 2012
Publication date:
February 14, 2013
Applicants:
Rheinische Friedrich-Wilhelms-Universitaet Bonn, BASF SE
Inventors:
Florian STECKER, Itamar Michael MALKOWSKY, Andreas FISCHER, Siegfried R. WALDVOGEL, Carolin REGENBRECHT
Abstract: A nucleic acid expression construct which encodes a fusion protein includes a reporter protein and a protein with a wild-type destruction signal. A sequence encoding the fusion protein is operably linked to a non-endogenous promoter. The fusion protein localizes during a cell cycle progression to subcellular structures selected from a cell cortex, a contractile ring, and a midbody.
Abstract: The present invention provides a method of using a neutral ionic liquid to at least one of stabilize a peroxidic explosive and to produce a stable solution of the peroxidic explosive which includes providing the neutral ionic liquid and using the neutral ionic liquid to at least one of stabilize the peroxidic explosive and to produce the stable solution of the peroxidic explosive. The present invention further provides a stable composition which includes a solution of at least one neutral ionic liquid and a detectable amount of a peroxidic explosive, a method of production thereof, and a method of use thereof as an odor sample.
Abstract: The invention relates to a method for isolating neural cells using tenascin-R compounds, tenascin-R fragments particularly suited for said method and tenascin-R fusion proteins, to recombinant preparation of said tenascin-R compounds, and to a kit for carrying out said method and to the use of said method for preparing high-purity neural cell populations. The invention further relates to antibodies suitable for detecting and isolating tenascin-R compounds.