Abstract: The invention provides bridged diindole compounds, related pharmaceutical compositions and methods of use thereof, for the prevention, palliation and/or treatment of nervous system disorders.

Abstract: A lithium ion battery comprising (i) at least one anode, (ii) at least one cathode containing a cathode active material selected from lithium ion containing transition metal compounds having a content of Manganese of from 50 to 100 wt.

Abstract: An electrolyte composition (A) containing at least one aprotic organic solvent and at least one compound of formula (I) wherein A+ is selected from Li+, Na+, K+, Cs+, and ammonium; is a bidentate radical derived from a (hetero)aromatic 1,2-, 1,3- or 1,4-diol, from a (hetero)aromatic 1,2-, 1,3- or 1,4-dicarboxylic acid or from a (hetero)aromatic 1,2-, 1,3- or 1,4-hydroxycarboxylic acid by abstracting the two H atoms of pairs of adjacent OH groups; and R1 and R2 are organic substituents.

Abstract: The invention provides wearable devices for effecting transcranial magnetic stimulation to be used by patients who have suffered brain injuries. Permanent magnets are shifted or rotated to deliver a time-varying magnetic field, preferably about the locus of the injury. In an embodiment, the strong magnetic fields of the permanent magnets are directed to the injured area for therapeutic purposes. A novel mechanism is provided that uses a small battery-powered electromagnet to interact with the weak peripheral magnetic fields of the permanent magnets and to shift the permanent magnets between two or more stable positions. As a result, a lightweight, quiet, wearable device with low power consumption is provided.

Abstract: The invention provides bridged diindole compounds, related pharmaceutical compositions and methods of use thereof, for the prevention, palliation and/or treatment of nervous system disorders.

Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents front the fabric upon uptake of water from the ambient environment.

Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.

Abstract: The present disclosure provides a novel distributed coaxial cable strain sensor that can measure a strain profile over the entire length of a cable. Individual strain sensing elements are constructed using Fabry-Perot interferometers, coaxial cable Bragg gratings, or other reflectometry-based sensing structures. By assembling three or more strain sensors together in a bundle, a coaxial cable shape sensing device can be constructed which is capable of accurate three dimensional position measurement.

Abstract: The present disclosure provides methods and apparatus to improve the dynamic coherent length of a sweep velocity-locked laser pulse generator (SV-LLPG) in an all-electronic fashion. A digital SV-LLPG is disclosed with two operation modes, i.e., unidirectional and bidirectional sweep modes; self-adaptive and time-dependent loop parameters (gain and location of poles/zeros); and, self-adaptive initial input curve. High frequency locking architectures, both single-side band (SSB) modulation method and direct phase measurement method, are provided to suppress the linewidth, or improve the coherent length, of the swept laser. A combination of high and low frequency locking, or a combination of multiple architectures disclosed in this invention, is utilized to achieve a higher level of linewidth reduction.

Abstract: The present disclosure provides methods and apparatus to improve the dynamic coherent length of a sweep velocity-locked laser pulse generator (SV-LLPG) in an all-electronic fashion. A digital SV-LLPG is disclosed with two operation modes, i.e., unidirectional and bidirectional sweep modes; self-adaptive and time-dependent loop parameters (gain and location of poles/zeros); and, self-adaptive initial input curve. High frequency locking architectures, both single-side band (SSB) modulation method and direct phase measurement method, are provided to suppress the linewidth, or improve the coherent length, of the swept laser. A combination of high and low frequency locking, or a combination of multiple architectures disclosed in this invention, is utilized to achieve a higher level of linewidth reduction.

Abstract: An electrolyte composition (A) containing at least one aprotic organic solvent and at least one compound of formula (I) wherein A+ is selected from Li+, Na+, K+, Cs+, and ammonium; is a bidentate radical derived from a (hetero)aromatic 1,2-, 1,3- or 1,4-diol, from a (hetero)aromatic 1,2-, 1,3- or 1,4-dicarboxylic acid or from a (hetero)aromatic 1,2-, 1,3- or 1,4-hydroxycarboxylic acid by abstracting the two H atoms of pairs of adjacent OH groups; and R1 and R2 are organic substituents.

Abstract: Disclosed is a method of measuring tacrolimus levels in a subject. In exemplary embodiments, the method comprises the steps of: collecting oral fluid from the subject; homogenizing the oral fluid; combining the homogenized oral fluid with a precipitating solvent; separating oral fluid components on a liquid chromatography column by gradient elution with a mixture of a solvent A and a solvent B, wherein the solvent A is about 2 mM ammonium acetate/0.1% (v/v) formic acid in water and solvent B is about 2 mM ammonium acetate/0.1% (v/v) formic acid in MeOH and wherein the amount of solvent B is increased from about 50% (v/v) to about 98% (v/v); and quantifying the amount of tacrolimus in the oral fluid by mass spectrometry.

Abstract: A flexible, electrically conductive composite is disclosed that includes a plurality of particles of elastomeric material and a conductive material. The conductive material at least partially covers the plurality of particles of elastomeric material. A first portion of the composite has undergone a force that has deformed a first portion of the particles of elastomeric material and broken up the conductive coating material.

Abstract: The present disclosure provides a novel fiber optic sensing device using ultra-weak, terahertz-range reflector structures. A fiber optic sensor device for distributed measurements (strain/temperature) includes an optical fiber detection arm having an inner core extending along a length of the optical fiber, an outer cladding surrounding the inner core, and at least one ultra-weak, terahertz-range reflector structure. Each reflector structure is comprised of two or more ultra-weak range reflectors (gratings) written at a spacing corresponding to the terahertz range and formed along a length of the inner core of the optical fiber. A narrow bandwidth, tunable laser interrogation system interrogates the optical fiber and measures changes in reflections and interference patterns caused by physical changes in the optical fiber.

Abstract: The present disclosure provides a sweep velocity-locked laser pulse generator (SV-LLPG) controlled using a digital phase locked loop (DPLL) circuit. The SV-LLPG is utilized for the interrogation of sub-terahertz-range fiber structures for sensing applications that require real-time data collection with mm-level spatial resolution. A laser generates chirped laser pulses via injection current modulation and a DPLL circuit locks the optical frequency sweep velocity. A high-quality linearly chirped laser pulse with a frequency excursion of 117.69 GHz at optical communication bands using a distributed feedback laser is provided.

Abstract: The present disclosure provides a novel distributed coaxial cable strain sensor that can measure a strain profile over the entire length of a cable. Individual strain sensing elements are constructed using Fabry-Perot interferometers, coaxial cable Bragg gratings, or other reflectometry-based sensing structures. By assembling three or more strain sensors together in a bundle, a coaxial cable shape sensing device can be constructed which is capable of accurate three dimensional position measurement.

Abstract: The present disclosure provides a sweep velocity-locked laser pulse generator (SV-LLPG) controlled using a digital phase locked loop (DPLL) circuit. The SV-LLPG is utilized for the interrogation of sub-terahertz-range fiber structures for sensing applications that require real-time data collection with mm-level spatial resolution. A laser generates chirped laser pulses via injection current modulation and a DPLL circuit locks the optical frequency sweep velocity. A high-quality linearly chirped laser pulse with a frequency excursion of 117.69 GHz at optical communication bands using a distributed feedback laser is provided.

Abstract: The present disclosure provides a novel fiber optic sensing device using ultra-weak, terahertz-range reflector structures. A fiber optic sensor device for distributed measurements (strain/temperature) includes an optical fiber detection arm having an inner core extending along a length of the optical fiber, an outer cladding surrounding the inner core, and at least one ultra-weak, terahertz-range reflector structure. Each reflector structure is comprised of two or more ultra-weak range reflectors (gratings) written at a spacing corresponding to the terahertz range and formed along a length of the inner core of the optical fiber. A narrow bandwidth, tunable laser interrogation system interrogates the optical fiber and measures changes in reflections and interference patterns caused by physical changes in the optical fiber.

Abstract: A microfluidic valve system is disclosed that includes a matrix, a hydrophilic acceptor region a hydrophilic transfer region, and a hydrophobic gap between the acceptor region and the transfer region.

Abstract: The present invention employed a method to control electrical activity in a target area of an animal's body by administering transcranial focal stimulation to the target area to adjust activity to normal levels. An advanced automated control system would first detect the abnormal electrical activity using tripolar concentric ring electrodes and then provides transcranial focal electrical stimulation to the target area using noninvasive tripolar concentric ring electrode system in a closed-loop continuous feedback. The automated control system would be adaptable to include the use of therapeutic drugs, either non-continuously or continuously, as a more comprehensive treatment of the abnormal electric activity.