Abstract: Disclosed is a method of measuring tacrolimus levels in a subject. In exemplary embodiments, the method comprises the steps of: collecting oral fluid from the subject; homogenizing the oral fluid; combining the homogenized oral fluid with a precipitating solvent; separating oral fluid components on a liquid chromatography column by gradient elution with a mixture of a solvent A and a solvent B, wherein the solvent A is about 2 mM ammonium acetate/0.1% (v/v) formic acid in water and solvent B is about 2 mM ammonium acetate/0.1% (v/v) formic acid in MeOH and wherein the amount of solvent B is increased from about 50% (v/v) to about 98% (v/v); and quantifying the amount of tacrolimus in the oral fluid by mass spectrometry.

Abstract: An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.

Abstract: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.

Abstract: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.

Abstract: The present teachings are directed toward hexagonally patterned porous titania synthesized from a titanium isopropoxide precursor using a viscous template of surface-active agents separating nanoscopic bicontinuous channels of water and isooctane. Subsequent catalyst metal salt reduction in the aqueous nanochannels deposits well-separated catalyst metal nanoparticles on the pore surfaces. These nanocomposites exhibit significantly higher carbon monoxide oxidation efficiency than that obtained with known supports with higher specific surface area; efficiency is believed to be due to decreased mass transfer resistance provided the presently disclosed support material.

Abstract: The invention generally features methods for the prevention and detection of a tick infestation. The present invention also features methods for decreasing the ability of a tick to feed on a subject.

Abstract: A networked storage server has a bottom-up caching hierarchy. The bottom level cache is located on an embedded controller that is a combination of network interface card (NIC) and host bus adapter (HBA). Storage data coming from or going to network are cached at this bottom level cache and metadata related to these data are passed to server host for processing. When cached data exceed the capacity of the bottom level cache, data are moved to the host memory that is usually much larger than the memory on the controller. For storage read requests from the network, most data are directly passed to the network through the bottom level cache from the storage device such as a hard drive or RAID. Similarly for storage write requests from the network, most data are directly written to the storage device through the bottom level cache without copying them to the host memory. Such data caching at the controller level dramatically reduces bus traffic resulting in great performance improvement for networked storages.

Abstract: A hardware environment for low-overhead profiling (HELP) technology significantly reduces profiling overhead and supports runtime system profiling and optimization. HELP utilizes a specifically designed embedded board. An embedded processor on the HELP board offloads tasks of profiling/optimization activities from the host, which reduces system overhead caused by profiling tools and makes HELP especially suitable for continuous profiling on production systems. By processing the profiling data-in parallel and providing feedback promptly, HELP effectively supports on-line optimizations including intelligent prefetching, cache managements, buffer control, security functions and more.