Patents Assigned to Rhodes Technology
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Patent number: 10988480Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.Type: GrantFiled: May 4, 2016Date of Patent: April 27, 2021Assignee: Rhodes TechnologiesInventors: Robert J. Kupper, Raymond C. Glowaky
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Publication number: 20210094964Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.Type: ApplicationFiled: September 8, 2020Publication date: April 1, 2021Applicant: RHODES TECHNOLOGIESInventors: Stuart James GEBBIE, Joshua R. GIGUERE, Keith MCCARTHY, Lonn S. RIDER
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Publication number: 20210094963Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.Type: ApplicationFiled: June 12, 2020Publication date: April 1, 2021Applicants: Purdue Pharma L.P., Purdue Pharmaceuticals L.P., Rhodes TechnologiesInventors: Robert CHAPMAN, Lonn S. RIDER, Qi HONG, Donald KYLE, Robert KUPPER
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Publication number: 20210061815Abstract: This invention relates to novel opioid derivatives of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R3, R4 and Z are as defined herein in the disclosure. The invention also relates to the use of such compounds for the treatment or prevention of, for example, pain.Type: ApplicationFiled: February 22, 2019Publication date: March 4, 2021Applicant: RHODES TECHNOLOGIESInventors: Ping CHANG, Raymond GLOWAKY, Michael David ROGERS
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Publication number: 20210046066Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.Type: ApplicationFiled: October 29, 2020Publication date: February 18, 2021Applicant: Rhodes TechnologiesInventors: C. Frederick M. HUNTLEY, Erik Wayne KATAISTO, Helge Alfred REISCH, Archana SHARMA
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Patent number: 10874662Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.Type: GrantFiled: June 19, 2019Date of Patent: December 29, 2020Assignee: Rhodes TechnologiesInventors: C. Frederick Huntley, Erik Wayne Kataisto, Helge Alfred Reisch, Archana Sharma
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Patent number: 10844072Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.Type: GrantFiled: July 31, 2019Date of Patent: November 24, 2020Assignee: RHODES TECHNOLOGIESInventors: Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
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Patent number: 10835528Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.Type: GrantFiled: June 19, 2019Date of Patent: November 17, 2020Assignee: Rhodes TechnologiesInventors: C. Frederick M. Huntley, Erik Wayne Kataisto, Helge Alfred Reisch, Archana Sharma
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Publication number: 20200325146Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.Type: ApplicationFiled: April 28, 2020Publication date: October 15, 2020Applicant: Rhodes TechnologiesInventors: Robert J. KUPPER, Raymond C. GLOWAKY
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Publication number: 20200317684Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.Type: ApplicationFiled: March 13, 2020Publication date: October 8, 2020Applicant: Rhodes TechnologiesInventors: Robert J. KUPPER, Raymond C. GLOWAKY
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Publication number: 20200223859Abstract: The disclosure relates to processes for reducing the amount of a compound of formula (I) or a salt or a solvate thereof present in a composition comprising compounds of formulae (I) and (II) or a salt or a solvate thereof.Type: ApplicationFiled: September 20, 2019Publication date: July 16, 2020Applicant: Rhodes TechnologiesInventors: Keith Edward MCCARTHY, Helge Alfred REISCH, Christopher SPROUT
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Patent number: 10696684Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.Type: GrantFiled: November 20, 2019Date of Patent: June 30, 2020Assignees: PURDUE PHARMA L.P., PURDUE PHARMACEUTICALS L.P, RHODES TECHNOLOGIESInventors: Robert Chapman, Lonn S. Rider, Qi Hong, Donald Kyle, Robert Kupper
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Publication number: 20200199134Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.Type: ApplicationFiled: July 31, 2019Publication date: June 25, 2020Applicant: RHODES TECHNOLOGIESInventors: Joshua Robert GIGUERE, Keith Edward MCCARTHY, Marcel SCHLEUSNER
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Patent number: 10689389Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.Type: GrantFiled: August 30, 2019Date of Patent: June 23, 2020Assignees: PURDUE PHARMA L.P., PURDUE PHARMACEUTICALS L.P., RHODES TECHNOLOGIESInventors: Robert Chapman, Lonn S. Rider, Qi Hong, Donald Kyle, Robert Kupper
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Patent number: 10624859Abstract: Disclosed in certain embodiments is a system and method of providing a dronabinol oral solid dosage form with increased stability.Type: GrantFiled: August 20, 2013Date of Patent: April 21, 2020Assignee: Rhodes TechnologiesInventor: Robert J. Kupper
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Publication number: 20200048269Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.Type: ApplicationFiled: July 22, 2019Publication date: February 13, 2020Applicant: RHODES TECHNOLOGIESInventors: Robert J. KUPPER, Raymond C. GLOWAKY
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Publication number: 20190367526Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.Type: ApplicationFiled: April 17, 2019Publication date: December 5, 2019Applicant: RHODES TECHNOLOGIESInventors: Stuart James Gebbie, Joshua R. Giguere, Keith McCarthy, Lonn S. Rider
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Publication number: 20190314364Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.Type: ApplicationFiled: June 19, 2019Publication date: October 17, 2019Applicant: Rhodes TechnologiesInventors: C. Frederick M. HUNTLEY, Erik Wayne KATAISTO, Helge Alfred REISCH, Archana SHARMA
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Publication number: 20190308986Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.Type: ApplicationFiled: February 8, 2019Publication date: October 10, 2019Applicant: RHODES TECHNOLOGIESInventors: Stuart James GEBBIE, Joshua R. Giguere, Keith McCarthy, Lonn S. Rider
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Publication number: 20190298713Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.Type: ApplicationFiled: June 19, 2019Publication date: October 3, 2019Applicant: Rhodes TechnologiesInventors: C. Frederick M. HUNTLEY, Erik Wayne KATAISTO, Helge Alfred REISCH, Archana SHARMA