Patents Assigned to Rhone-Poulenc
  • Pre-adherized polyester filament yarn for tire cord
    Patent number: 5547755
    Abstract: The method of making a pre-adherized polyester filament yarn with adhesion properties for rubber includes applying a pre-adherizing agent to a polyester filament yarn having a boiling water shrinkage value of <20% while spinning it at not less than 3200 m/min, heat treating the pre-adherized polyester filament yarn with hot air on a bobbin for several days at from 50.degree. to 90.degree. C., and then subjecting the conditioned POY to a single drawing step in which the take-off speed is 1.7 to 2.2 times faster than the inlet speed. Impregnated tire cord made from the polyester filament yarn so treated has a tensile strength of 60 to 70 cN/tex and a tempered shrinkage test value at 190.degree. C. of less than 3.5%, an adhesive power of 18 to 25 daN to rubber, an appearance grade of 2.5-4.0 and a dimensional stability value of greater than 24,000 cN/tex.sup.2.
    Type: Grant
    Filed: September 5, 1995
    Date of Patent: August 20, 1996
    Assignee: Rhone-Poulenc Viscosuisse SA
    Inventors: Peter Reinthaler, Armin Mueller
  • 1-Alkoxy-2-(alkoxy- or cycloalkoxy-)-4-(cyclothioalkyl- or cyclothioalkenyl-) benzenes as inhibitors of cyclic AMP phosphodiesterase and tumor necrosis factor
    Patent number: 5541219
    Abstract: This invention is directed to 1-alkoxy-2-(alkoxy- or cycloalkyloxy-)-4-(cyclothioalkyl- or cyclothioalkenyl-)benzene compounds that inhibit cyclic AMP phosphodiesterase or tumor necrosis factor (TNF) and are useful in treating patients suffering from disease state capable of being modulated by inhibiting production of cyclic AMP phosphodiesterase or TNF by administering the compound to the patient. The invention is also directed to the preparation of these compounds, pharmaceutical compositions containing these compounds and methods for their pharmaceutical use.
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: July 30, 1996
    Assignee: Rhone-Poulenc Rorer Limited
    Inventors: Garry Fenton, Jonathan S. Mason, Malcolm N. Palfreyman, Andrew J. Ratcliffe
  • Expression cloning of c-src SH3-domain binding proteins
    Patent number: 5541109
    Abstract: This invention provides a unique SH3 binding domain core motif of the sequence RPLPXXP and cDNA clones encoding proteins which interact with the SH3 domain of c-src, as well as the amino acid sequences which mediate this binding.Another embodiment of this invention is a method of identifying SH3-binding proteins and elucidating the sequences which mediate binding. This method may be used as an assay to select compounds which bind to this site and which inhibit or enhance the binding of the SH3 domain.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: July 30, 1996
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: George H. Searfoss, III, Yuri D. Ivashchenko, Michael C. Jaye, Victoria J. South, Stephen M. French, Christopher Cheadle, George A. Ricca
  • Non-yellowing textile softening process in which a composition comprising a polyorganosiloxane is used
    Patent number: 5540952
    Abstract: Process for conditioning textile materials in order to enable them to have, especially, a pleasant handle and a very low or even non-existent yellowing, characterized in that the textile materials are brought into contact with a composition comprising a polyorganosiloxane having, per mole, at least one unit of general formula: ##EQU1## in which: R can represent a C.sub.1 -C.sub.4 alkyl radical;X can represent a hydrolysable radical;Z represents a residue containing (a) sterically hindered piperidyl group(s) of formulae: ##STR1## in which R.sup.1 is a divalent hydrocarbon radical, R'.sup.1 is a trivalent hydrocarbon radical, U and U' represent --O--, --NH-- or --N(alkyl)--, R.sup.2 can represent a C.sub.1 -C.sub.3 alkyl radical and R.sup.3 is H or R.sup.2,a and b are chosen from 0, 1 and 2,the sum a+b being not greater than 2.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: July 30, 1996
    Assignee: Rhone-Poulenc Chimie
    Inventors: Edith Canivenc, Jose-Luis Roca-Ortega, Andrew Van Der Spuy
  • Derivatized guar gum composition and process for making it
    Patent number: 5536825
    Abstract: Derivatized guar gum which demonstrates greater than 75% light transmission at a wavelength of from about 500-600 nanometers when dispersed in water in the amount of 0.5 parts per 100 parts water and the process for producing such guar gum is disclosed.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: July 16, 1996
    Assignee: Rhone-Poulenc Inc.
    Inventors: Michael H. Yeh, Ian William Cottrell
  • Detersive polyanhydroaspartic acids and biodegradable hydrolysates thereof
    Patent number: 5536813
    Abstract: Novel polyanhydroaspartic acids (containing not more than 3% of NH groups of the imide moieties thereof relative to the total amount of CH moieties of the succinimide moieties thereof) and the at least 90%.+-.5% biodegradable hydrolysates thereof (containing not more than 3% of primary amide groups relative to the secondary amide groups of the aspartic moieties thereof) are well suited as detergent (co)builders, the former being prepared by thermally polymerizing aspartic acid in the presence of an effective amount of at least one boron compound having at least one B-OH group, or precursor thereof, and the latter by hydrolyzing the polyanhydroaspartic acid thus obtained.
    Type: Grant
    Filed: April 25, 1994
    Date of Patent: July 16, 1996
    Assignee: Rhone-Poulenc Chimie
    Inventors: Maurice Charpenel, Jean-Luc Lepage
  • Aliphatic amino bis-aryl squalene synthase inhibitors
    Patent number: 5534532
    Abstract: This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: July 9, 1996
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Robert A. Groneberg, John R. Regan, Kent W. Neuenschwander, Anthony C. Scotese
  • Zirconium/cerium mixed oxide catalyst/catalyst support compositions having high/stable specific surfaces
    Patent number: 5532198
    Abstract: Zirconium/cerium mixed oxides (optionally including thermally stabilizing dopant values), comprising solid solutions thereof, having contents of zirconium of up to 99% by weight, and having high specific surface areas, are well suited as catalysts and/or catalyst supports, notably for the treatment/conversion of vehicular exhaust gases; such ZrO.sub.2 /CeO.sub.2 mixed oxides are conveniently prepared by (i) intimately admixing a zirconium sol with a cerium sol, the ratio r of the mean diameter r.sub.1 of the particles of the zirconium sol to the diameter r.sub.2 of the particles of the cerium sol being at least 5, (ii) spray drying the admixture thus obtained, and (iii) calcining the dried material.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: July 2, 1996
    Assignee: Rhone-Poulenc Chimie
    Inventors: Thierry Chopin, Gabriel Vilmin
  • Taxoids, their preparation and pharmaceutical compositions containing them
    Patent number: 5532388
    Abstract: New taxoids of general formula (I), their preparation and pharmaceutical compositions containing them.In general formula (I),Ar represents an aryl radicalR represents a hydrogen atom or an acetyl, alkoxyacetyl or alkyl radical,R.sub.1 represents a benzoyl radical or a radical of formula R.sub.2 --O--CO-- in which R.sub.2 represents an optionally substituted alkyl radical, an alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radicalThe new products of general formula (I) have a remarkable antitumour activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 2, 1996
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herve Bouchard, Jean-Dominique Bourzat, Alain Commercon
  • Twin-screw extrusion of silicone doughs suited for SiH/SiVi RTV compositions
    Patent number: 5531923
    Abstract: Silicone doughs suitable for incorporation into diorganopolysiloxane compositions crosslinkable into elastomeric state are rapidly and conveniently formulated by continuously and simultaneously individually introducing along the longitudinal axis of a twin-screw extruder, via a plurality of longitudinally spaced discrete inlet entries, and twin-screw extruding (a) a polydiorganosiloxane oil having a viscosity at 25.degree. C. of less than 500,000 mPa.s and containing at least two .tbd.Si-CH=CH.sub.2 functional groups per molecule, (b) water, (c) silica, and (d) a polysilazane which is liquid under normal conditions of temperature and pressure.
    Type: Grant
    Filed: May 4, 1994
    Date of Patent: July 2, 1996
    Assignee: Rhone-Poulenc Chimie
    Inventors: Loic Le Blanc, Rene Pagliari
  • Crosslinked polysaccharides useful as absorbent materials
    Patent number: 5532350
    Abstract: A solid composition of matter comprising one or more polysaccharides which has been cross-linked with either titanium or zirconium cross-linking agents is provided. The composition demonstrates absorbent properties and is useful in absorbent articles of manufacture. Also provided is a method for preparing the compositions.
    Type: Grant
    Filed: February 15, 1994
    Date of Patent: July 2, 1996
    Assignee: Rhone-Poulenc Inc.
    Inventors: Ian W. Cottrell, Animesh Goswami, Manjit S. Chowdhary
  • Methods for purification of recombinantly produced proteins
    Patent number: 5530100
    Abstract: Recovery of the 52/48 kDa tryptic fragment of vWF or peptide subfragments thereof produced in the form of inclusion bodies from recombinant host cells is carried out by providing a washed recombinant host cell suspension, adding a detergent and subjecting the cells to mechanical disruption. A second detergent is added, followed by another mechanical disruption and centrifugation to a pellet. The pellet is resuspended in a buffer and subjected to another mechanical disruption. Inclusion bodies are washed, resuspended and then recovered. In addition, endotoxins and DNA are removed from inclusion bodies containing the 52/48 kDa tryptic fragment of vWF or peptide subfragments thereof by mechanically disrupting the inclusion bodies in an aqueous buffer containing a detergent. A washed pellet is formed from these mechanically disrupted inclusion bodies and dissolved in a denaturant.
    Type: Grant
    Filed: May 7, 1990
    Date of Patent: June 25, 1996
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Thomas L. J. Darling, Lida Y. Akhnana, Jonathan J. Mitschelen, Michael E. Hrinda
  • Process for the preparation of L-aspartic acid from ammonium aspartate
    Patent number: 5530160
    Abstract: Process for the preparation of L-aspartic acid by treatment of ammonium aspartate using an alcoholic (preferably methanolic or ethanolic) fumaric acid solution according to an added fumaric acid/ammonium aspartate present molar ratio of the order of 0.05 to 0.8 and preferably of the order of 0.1 to 0.65, the said alcoholic solution containing of the order of 1 to 15% and preferably of 3 to 10% of its weight of fumaric acid.
    Type: Grant
    Filed: April 17, 1995
    Date of Patent: June 25, 1996
    Assignee: Rhone-Poulenc Chimie
    Inventors: Olivier Nore, Andre Pilot
  • B.E.T. specific surface-stabilized ceria
    Patent number: 5529969
    Abstract: Ceric oxide (ceria) particulates exhibiting a particularly small crystallite size, well suited for catalyst/catalyst carrier applications, include a specific surface-stabilizing amount of silicon values (preferably less than 1% by weight thereof, expressed as SiO.sub.2) and have a specific surface of at least 40 m.sup.2 /g after calcination at 800.degree. C. for 6 hours and of at least 20 m.sup.2 /g after calcination at 1,000.degree. C. for 6 hours; such CeO.sub.2 particulates are advantageously prepared by (a) suspending certain ceric hydroxides in a basic aqueous reaction medium containing a silicon compound, (b) autoclaving the resulting suspension, (c) cooling and depressurizing such medium of reaction, (d) separating a ceric hydroxide therefrom, and (e) calcining the ceric hydroxide thus separated.
    Type: Grant
    Filed: December 9, 1992
    Date of Patent: June 25, 1996
    Assignee: Rhone-Poulenc Chimie
    Inventors: Lionel Bonneau, Thierry Chopin, Olivier Touret
  • Use of 2-amino-6-(trifluoromethoxy)benzothiazole for obtaining a medicament for the treatment of amyotrophic lateral sclerosis
    Patent number: 5527814
    Abstract: Use of 2-amino-6-(trifluoromethoxy)benzothiazole, or a salt of this compound with a pharmaceutically acceptable acid, for obtaining a medicament intended for the treatment of motor neuron diseases, in particular amyotrophic lateral sclerosis, and especially amyotrophic lateral sclerosis with early bulbar involvement or the bulbar form of the disease.
    Type: Grant
    Filed: October 21, 1994
    Date of Patent: June 18, 1996
    Assignee: Rhone Poulenc Rorer S.A.
    Inventor: Erik Louvel
  • Phenylpyrazole fungicides
    Patent number: 5523280
    Abstract: Phenylpyrazoles of the formula: ##STR1## in which: X.dbd.H, hal, NO.sub.2, CN, SCN, alkyl (C.sub.1 -C.sub.4), alkenyl (C.sub.2 -C.sub.4), alkynyl (C.sub.2 -C.sub.4), alkoxy (C.sub.1 -C.sub.4), alkylthio (C.sub.1 -C.sub.4), phenyl, phenoxy; mono- or di- alkyl- or phenyl- amino; alkylcarbonyl, carbamoyl, carboxyl, benzoyl; alkyl- sulphinyl or sulphonyl;Y, Z.dbd.H, hal, OH, NO.sub.2, NO, CN, SCN, alkyl (C.sub.1 -C.sub.4), alkenyl (C.sub.2 -C.sub.4), alkynyl (C.sub.2 -C.sub.4), alkoxy (C.sub.1 -C.sub.4), alkylthio (C.sub.1 -C.sub.4), phenyl, phenoxy; mono- or di- alkyl- or phenyl- amino; alkylcarbonyl, carbamoyl, carboxyl, benzoyl; alkyl- sulphinyl or sulphonyl, for example; andY, Z may also form a bridge of 1 to 4 atoms, of which at least one can be a hetero atom, optionally substituted. The products are useful as fungicides in agriculture.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: June 4, 1996
    Assignee: Rhone-Poulenc Agrochimie
    Inventors: Alain Chene, Raymond Peignier, Jean-Pierre A. Vors, Jacques Mortier, Richard Cantegril, Denis Croisat
  • N-acylphosphatidylethanolamines as anti-oxidants
    Patent number: 5523429
    Abstract: A method of inhibiting oxidation of products containing unsaturated fatty acids and their derivatives comprises treating the unsaturated fatty acids and their derivatives with N-acylphosphatidylethanolamines. Preferred N-acylphosphatidylethanolamines are N-acetylphosphatidylethanolamine and N-oleoylphosphatidylethanolamine.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: June 4, 1996
    Assignee: Rhone-Poulenc Rorer-GmbH
    Inventor: Miklos Ghyczy
  • Powder inhaler having capsule holding structure and anti-static walls
    Patent number: 5522383
    Abstract: An inhaler for inhaling pulverulent medicament from within a capsule comprises a chamber (24) within which the capsule is free to rotate while having its longitudinal axis in the median plane of the chamber and thus generally parallel to the front and rear walls (30) and (31) of the chamber, by virtue of the fact that the spacing between said front and rear walls is less than the axial length of the capsule but just greater than the diameter of the capsule. The device includes pins (21) serving as opening means to pierce the ends of the capsule while it is seated in a recess (25), whereupon the retraction of the pins (21) allows the capsule to be entrained into swirling airflow in the chamber (24) during inhalation of air through air inlets (26) and out through a mouthpiece nozzle (27).
    Type: Grant
    Filed: February 16, 1993
    Date of Patent: June 4, 1996
    Assignee: Rhone-Poulenc Rorer Ltd.
    Inventors: John R. Calvert, Robert S. Cook, Michael A. Hobbs, Ann-Marie Leighton, Gordon T. Simpkin, Roy Trunley, Anthony D. West
  • Optically active alkylammonium 1-(3-aminophenyl)-ethanesulphonate derivatives, their preparation and their use
    Patent number: 5523469
    Abstract: This invention relates to levogyral isomers of alkylammonium (amino-3 phenyl)-1 ethanesulphonate derivatives of formula (I) in which R+ denotes a tetraalkylammonium or trialkylphenylalkylammonium residue. The invention also concerns the preparation and use of said derivatives.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: June 4, 1996
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventor: Claude Guyon
  • Pesticide substituted diketonitriles
    Patent number: H1552
    Abstract: The invention relates to diketontrile derivatives which have been discovered useful against arthropods, plant nematodes, helminth protozoan pests or as intermediates for such useful compounds which have a general formula: ##STR1##
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: June 4, 1996
    Assignee: Rhone-Poulenc Inc.
    Inventors: Paul A. Cain, David T. Chou, Themistocles D. J. D'Silva, Daniel B. Gant, Nancy D. Herman