Abstract: Methods for inhibiting tissue ossification or calcification in a subject, comprising administering a therapeutically effective amount of BMP I inhibitor-loaded microparticles to a subject in need thereof, wherein the administration provides local and sustained release of the BMP I inhibitor thereby inhibiting tissue ossification or calcification.
Type:
Grant
Filed:
November 29, 2018
Date of Patent:
May 3, 2022
Assignees:
University of Pittsburgh—Of the Commonwealth System of Higher Education, Ri.Med Foundation
Inventors:
Riccardo Gottardi, Peter Alexander, Patrick A. Bianconi, Steven R. Little
Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.
Type:
Application
Filed:
August 30, 2021
Publication date:
December 16, 2021
Applicants:
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Ri.MED Foundation
Inventors:
Steven R. Little, Riccardo Gottardi, Mintai Peter Hwang, Daniel DeSantis
Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.
Type:
Grant
Filed:
January 7, 2019
Date of Patent:
September 28, 2021
Assignees:
UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, RI.MED FOUNDATION
Inventors:
Steven R. Little, Riccardo Gottardi, Mintai Peter Hwang, Daniel DeSantis