Abstract: A hydroxyalkylated heterocyclic base is prepared by reacting a heterocyclic base with an alkylene carbonate in dimethylacetamide as a solvent, wherein the hydroxyalkylated heterocyclic base is isolated from the solvent using isopropanol or tert-butylmethylether.
Type:
Application
Filed:
August 8, 2002
Publication date:
June 22, 2006
Applicant:
RIBAPHARM INC.
Inventors:
Kanda Ramasamy, Jean-Luc Girardet, Haoyun An, Zhi Hong, Robert Orr
Abstract: A polymerase inhibitor has first moiety coupled to a second moiety via an optional linker in which the first moiety binds to an initiation nucleotide binding site of a polymerase and forms at least two hydrogen bonds with an RNA template strand that is associated with the polymerase, and in which the second moiety comprised a compound that binds to a site proximal to the nucleotide binding site of the polymerase and thereby increases the affinity of the polymerase inhibitor to the polymerase.
Type:
Grant
Filed:
December 27, 2002
Date of Patent:
June 14, 2005
Assignee:
Ribapharm Inc.
Inventors:
Nanhua Yao, Haoyun An, Todd Appleby, Shahul Nilar, Yili Ding, Zhi Hong
Abstract: Compositions and methods for pyrrolo[2,3-d]pyrimidine nucleoside analogs having substituents at the C4′ and C5′ positions of the ribofuranose moiety are presented. Contemplated compositions exhibit, among other things, anti-cancer and immunomodulating effects at reduced cytotoxicity.
Type:
Grant
Filed:
February 28, 2001
Date of Patent:
December 14, 2004
Assignee:
Ribapharm Inc.
Inventors:
Robert Tam, Guangyi Wang, Johnson Lau, Zhi Hong
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