Patents Assigned to Ribokine LLC
  • INTRACELLULAR TRANSLATION OF CIRCULAR RNA
    Publication number: 20180080041
    Abstract: A circular mRNA molecule possessing features resembling native mammalian mRNA demonstrates improved translation, while retaining the properties of an extremely long half-life inside cells. This circular mRNA is functional inside mammalian cells, being able to compete against native cellular mRNAs for the eukaryotic translation initiation machinery. The invention possesses additional RNA elements compared to a previous invention containing only an IRES element for successful in vitro or in vivo translation.
    Type: Application
    Filed: November 14, 2017
    Publication date: March 22, 2018
    Applicant: Ribokine LLC
    Inventor: Robert KRUSE
  • INTRACELLULAR TRANSLATION OF CIRCULAR RNA
    Publication number: 20160083747
    Abstract: A circular mRNA molecule possessing features resembling native mammalian mRNA demonstrates improved translation, while retaining the properties of an extremely long half-life inside cells. This circular mRNA is functional inside mammalian cells, being able to compete against native cellular mRNAs for the eukaryotic translation initiation machinery. The invention possesses additional RNA elements compared to a previous invention containing only an IRES element for successful in vitro or in vivo translation.
    Type: Application
    Filed: May 13, 2014
    Publication date: March 24, 2016
    Applicant: Ribokine LLC
    Inventor: Robert KRUSE