Abstract: This disclosure is directed to methods of treating or preventing mitochondrial dysfunction or mitochondrial disease in a subject comprising administration of probucol, or a pharmaceutically acceptable salt thereof. This disclosure is also directed to methods of diagnosing genetic mitochondrial disease in a subject prior to and in association with said treatment or prevention. This disclosure is also directed to methods of assessing and managing a subject with mitochondrial dysfunction or mitochondrial disease using a composite measurement.
Type:
Application
Filed:
August 5, 2024
Publication date:
January 2, 2025
Applicant:
RIBONOVA INC.
Inventors:
Marni J. Falk, Shana E. McCormack, Zaraxuela Zolkipli-Cunningham, Nigel L. Webb, Eric C. Yuen, Anthony W. Ford-Hutchinson
Abstract: This disclosure is directed to methods of methods of computing a composite measurement comprising employing two or more sub-instruments to measure one or more clinical symptoms of mitochondrial dysfunction or mitochondrial disease. This disclosure is also directed to methods of assessing and managing a subject with mitochondrial dysfunction or mitochondrial disease using a composite measurement.
Type:
Application
Filed:
June 26, 2019
Publication date:
December 2, 2021
Applicants:
RIBONOVA INC., The Children's Hospital of Philadelphia
Inventors:
Marni J. Falk, Nigel L. Webb, Shana E. McCormack, Eric C. Yuen, Zarazuela Zolkipli-Cunningham, Anthony W. Ford-Hutchinson
Abstract: This disclosure is directed to methods of treating or preventing mitochondrial dysfunction or mitochondrial disease in a subject comprising administration of probucol, or a pharmaceutically acceptable salt thereof. This disclosure is also directed to methods of diagnosing genetic mitochondrial disease in a subject prior to and in association with said treatment or prevention. This disclosure is also directed to methods of assessing and managing a subject with mitochondrial dysfunction or mitochondrial disease using a composite measurement.
Type:
Application
Filed:
June 26, 2019
Publication date:
September 16, 2021
Applicant:
RIBONOVA INC.
Inventors:
Marni J. Falk, Shana E. McCormack, Zaraxuela Zolkipli-Cunningham, Nigel L. Webb, Eric C. Yuen, Anthony W. Ford-Hutchinson