Patents Assigned to Ribozyme Pharmaceutical
  • 2'-O-alkylthioalkyl and 2'-c-alkylthioalkyl-containing nucleic acids
    Patent number: 6239272
    Abstract: A compound having the formula: wherein, R1 represents 2′-O-R3-thio-R3 and/or 2′-C-R3-thio-R3, wherein R3 is a compound independently selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester, X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: May 29, 2001
    Assignee: Ribozyme Pharmaceutical
    Inventors: Leonid Beigelman, Alex Karpeisky