Patents Assigned to Ribozyme Pharmaceuticals, Incorporated
  • Synthetic ribonucleic acids with RNAse activity
    Patent number: 6528640
    Abstract: Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: March 4, 2003
    Assignee: Ribozyme Pharmaceuticals, incorporated
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
  • Nucleoside triphosphates and their incorporation into oligonucleotides
    Patent number: 6482932
    Abstract: Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: November 19, 2002
    Assignee: Ribozyme Pharmaceuticals, Incorporated
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
  • Synthesis, deprotection, analysis and purification of RNA and ribozymes
    Patent number: 6469158
    Abstract: Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: October 22, 2002
    Assignee: Ribozyme Pharmaceuticals, Incorporated
    Inventors: Nassim Usman, Francine Wincott, David Sweedler, Leonid Beigelman, Lech W. Dudycz, Susan Grimm, Anthony DiRenzo, Danuta Tracz
  • 2?-O-alkylthioalkyl and 2?-C-alkythioalkyl containing nucleic acids
    Patent number: 6451540
    Abstract: A compound having the formula: wherein, R1 represents 2′-O-alkylthioalkyl or 2′-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: September 17, 2002
    Assignee: Ribozyme Pharmaceuticals, Incorporated
    Inventors: Leonid Beigelman, Alex Karpeisky
  • Amido and peptido modified catalytic oligonucleotides
    Patent number: 6379954
    Abstract: Oligonucleotide comprising a nucleotide base having the formula: wherein B is a nucleotide base or hydrogen; R1, R2 and R3 independently is selected from the group consisting of hydrogen, an alkyl group containing between 2 and 10 carbon atoms inclusive, an amine, an amino acid, and a peptide containing between 2 and 5 amino acids inclusive; and the zigzag lines are independently hydrogen or a bond.
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: April 30, 2002
    Assignee: Ribozyme Pharmaceuticals, Incorporated
    Inventors: Lech Dudycz, Jasenka Matulic-Adamic, Leonid Beigelman