Patents Assigned to Rice University
  • Patent number: 11371014
    Abstract: The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: June 28, 2022
    Assignee: William Marsh Rice University
    Inventors: Jordan Miller, Anderson Ta, Bagrat Grigoryan
  • Publication number: 20220184417
    Abstract: The present invention provides a brachytherapy applicator device having: an elongate body defining a plurality of brachytherapy needle channels, each adapted and configured to receive a brachytherapy needle; a proximal end defining a plurality of proximal openings, each in communication with one of the plurality of brachytherapy needle channels; and a distal end defining a plurality of distal openings, each in communication with one of the plurality of brachytherapy needle channels, wherein at least some of the plurality of brachytherapy needle channels are curved away from a central axis of the elongate body at the distal end such that a brachytherapy needle inserted therethrough will engage with tissue lateral to a cross-sectional profile of the distal end of the elongate body.
    Type: Application
    Filed: December 14, 2021
    Publication date: June 16, 2022
    Applicants: Baylor College of Medicine, William Marsh Rice University
    Inventors: Alexander Hanania, Michelle S. Ludwig, Elisa Arango, Susannah Dittmar, Krithika Kumar, Lauren Payne, Sanika Rane, Andrea Samantha Gobin
  • Publication number: 20220180080
    Abstract: Remote measuring and sensing. Some example embodiment related to optical energy harvesting by identification device, such as infrared identification device (IRID devices). Other embodiments relate to RFID device localization using low frequency source signals. Yet still other embodiments related to energy harvesting by RFID in electric fields in both conductive and non-conductive environments.
    Type: Application
    Filed: February 28, 2022
    Publication date: June 9, 2022
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Aydin Babakhani, Seyed Mohammad Kazem Pour, Mahdi Forghani, Yuxiang Sun, Yaswanth Kumar Cherivirala
  • Publication number: 20220168579
    Abstract: The disclosure describes new apparatus, systems and methods utilizing magnetoelectric neural stimulators with tunable amplitude and waveform. Specific embodiments of the present disclosure include a magnetoelectric film, a magnetic field generator and an electrical circuit coupled to the magnetoelectric film, in particular embodiments, the electrical circuit comprises components configured modify an electrical output signal produced by the magnetoelectric film. In certain embodiments, the electrical circuit is configured to modify the electric signal to charge a charge storage element, to transmit data to an implantable wireless neural stimulator, and to provide a stimulation output to electrodes.
    Type: Application
    Filed: April 3, 2020
    Publication date: June 2, 2022
    Applicant: William Marsh Rice University
    Inventors: Jacob ROBINSON, Kaiyuan YANG, Zhanghao YU, Joshua CHEN, Amanda SINGER, Benjamin AVANTS, Nishant VERMA
  • Patent number: 11331627
    Abstract: In some embodiments, the present disclosure pertains to systems and methods for distilling a fluid by exposing the fluid to a porous membrane that includes a surface capable of generating heat. In some embodiments, the heat generated at the surface propagates the distilling of the fluid by converting the fluid to a vapor that flows through the porous membrane and condenses to a distillate. In some embodiments, the surface capable of generating heat is associated with a photo-thermal composition that generates the heat at the surface by converting light energy from a light source to thermal energy. In some embodiments, the photo-thermal composition includes, without limitation, noble metals, semiconducting materials, dielectric materials, carbon-based materials, composite materials, nanocomposite materials, nanoparticles, hydrophilic materials, polymers, fibers, meshes, fiber meshes, hydrogels, hydrogel meshes, nanomaterials, and combinations thereof.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: May 17, 2022
    Assignee: William Marsh Rice University
    Inventors: Qilin Li, Jinjian Wu, Nancy C. Halas, Katherine R. Zodrow, Haoli Guo, Jiarui Xu, Cong Yu
  • Publication number: 20220143270
    Abstract: The disclosure describes new devices and methods for vascularizing devices and methods for implanted diagnostics and therapeutics. The present disclosure provides, in certain embodiments, a device containing a degradable shell and a non-degradable core. In certain embodiments, the non-degradable core can include encapsulated therapeutic cells and/or biosensors, wherein the degradable shell serves as a scaffold for blood vessel growth, resulting in enhanced blood flow to the cells and/or biosensors.
    Type: Application
    Filed: February 17, 2020
    Publication date: May 12, 2022
    Applicant: William Marsh Rice University
    Inventors: Omid VEISEH, Bagrat GRIGORYAN, Daniel Warren SAZER, Siavash PARKHIDEH, Jordan MILLER, Sudip MUKHERJEE
  • Publication number: 20220125581
    Abstract: Some embodiments are directed to methods for serially expanding an artificial heart valve within a pediatric patient. For example, the artificial heart valve can be implanted into the pediatric patient during a first procedure, and then expanded during a second procedure to accommodate for the pediatric patient's growth. Some embodiments include introducing an expander into the implanted valve when the frame is expanded to a first working diameter, and then actuating the expander to expand the frame to a second working diameter greater than the first working diameter, to accommodate for the pediatric patient's growth.
    Type: Application
    Filed: September 17, 2021
    Publication date: April 28, 2022
    Applicants: Baylor College of Medicine, William Marsh Rice University
    Inventors: Henri JUSTINO, Daniel HARRINGTON, Kwonsoo CHUN
  • Publication number: 20220117731
    Abstract: Some embodiments are directed to a transcatheter and serially-expandable artificial heart valve, e.g., to be minimally-invasively implanted into a pediatric patient during a first procedure, and then expanded during a second procedure to accommodate for the pediatric patient's growth. Some embodiments include an expandable frame having a compressed, delivery configuration, and an expanded, deployed configuration, in which the valve is implantable within the patient. The valve can have a first working condition when the frame is expanded to a first diameter and a second working condition when the frame is expanded to a second diameter greater than the first diameter. The valve can include a plurality of leaflets configured to accommodate the expansion of the frame and growth of the patient.
    Type: Application
    Filed: September 13, 2021
    Publication date: April 21, 2022
    Applicants: Baylor College of Medicine, William Marsh Rice University
    Inventors: Henri JUSTINO, Daniel HARRINGTON, Kwonsoo CHUN
  • Publication number: 20220098642
    Abstract: Provided herein are methods of quantitative amplicon sequencing, for labeling each strand of targeted genomic loci in a DNA sample with an oligonucleotide barcode sequence by polymerase chain reaction, and amplifying the genomic region(s) for high-throughput sequencing. The methods can be used for the simultaneous detection of copy number variation (CNV) in a set of genes of interest, by quantifying the frequency of extra copies of each gene. In addition, these methods provide for the quantitation of the allele ratio of different genetic identities for targeted genomic loci using multiplexed PCR. In addition, these methods provide for the detection of mutations and quantitation of the variant allele frequency.
    Type: Application
    Filed: January 2, 2020
    Publication date: March 31, 2022
    Applicant: William Marsh Rice University
    Inventors: David ZHANG, Peng DAI, Ruojia WU
  • Publication number: 20220090168
    Abstract: The present invention provides an oligonucleotide composition including a blocker and a first primer oligonucleotide. The blocker oligonucleotide includes a first sequence having a target-neutral subsequence and a blocker variable subsequence. The non-target specific subsequence is flanked on its 3? and 5? ends by the target-neutral subsequence and is continuous with the target-neutral subsequence. The first primer oligonucleotide is sufficient to induce enzymatic extension; herein the first primer oligonucleotide includes a second sequence. The second sequence overlaps with the 5? end of the target-neutral subsequence by at least 5 nucleotides; herein the second sequence includes an overlapping subsequence and a non-overlapping subsequence. The second sequence does not include the non-target specific subsequence.
    Type: Application
    Filed: November 29, 2021
    Publication date: March 24, 2022
    Applicant: William Marsh Rice University
    Inventors: David Yu ZHANG, Ruojia WU, Juexiao WANG
  • Patent number: 11274124
    Abstract: In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: March 15, 2022
    Assignee: William Marsh Rice University
    Inventors: Kyriacos C. Nicolaou, Rohan Diliprao Erande, Dionisios Vourloumis, Kiran Kumar Pulukuri, Stephan Rigol
  • Patent number: 11263412
    Abstract: Remote measuring and sensing. Some example embodiment related to optical energy harvesting by identification device, such as infrared identification device GRID devices). Other embodiments relate to RFID device localization using low frequency source signals. Yet still other embodiments related to energy harvesting by RFID in electric fields in both conductive and non-conductive environments.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: March 1, 2022
    Assignee: William Marsh Rice University
    Inventors: Aydin Babakhani, Seyed Mohammad Kazem Pour, Mahdi Forghani, Yuxiang Sun, Yaswanth Kumar Cherivirala
  • Publication number: 20220055904
    Abstract: Resistive memory devices having laser-induced graphene (LIG) composites, and methods of making resistive memory devices having LIG composites.
    Type: Application
    Filed: December 30, 2019
    Publication date: February 24, 2022
    Applicants: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY, WILLIAM MARSH RICE UNIVERSITY
    Inventors: James Mitchell Tour, Duy X. Luong, Kaichun Yang, Christopher John Arnusch, Swatantra Pratap Singh, Amit Kumar Thakur, Michael G. Stanford, John T. Li, Steven E. Presutti
  • Publication number: 20220048033
    Abstract: The disclosure describes apparatus and methods for multiplexed amplification and detection of nucleic acid targets in a sample. Embodiments of the present disclosure include a mechanical system configured to provide loading, vertical positioning and clamping of a chip; a thermal control system configured to maintain distinct temperatures of the chip, and an optical fluorescence imaging system.
    Type: Application
    Filed: September 13, 2019
    Publication date: February 17, 2022
    Applicant: William Marsh Rice University
    Inventors: David Yu ZHANG, Dmitriy A. KHODAKOV, Xuemeng ZHANG
  • Patent number: 11246962
    Abstract: Graphene compositions used for neuronal repair and treatments, and, in particular neuronal scaffold-water soluble graphene for treatment of severed spinal cords and other neuronal repairs. The neuronal scaffold-water soluble graphene can be PEGylated GNR used in combination with a fusogen agent, such as PEG600.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: February 15, 2022
    Assignee: William Marsh Rice University
    Inventors: James M. Tour, William Sikkema
  • Publication number: 20220011646
    Abstract: A harmonic light-generating metasurface includes a base substrate and a plurality of structures, that include nonlinear material, that are disposed in a pattern on a surface of the base substrate. Each structure of the plurality of structures individually supports a magnetic dipole mode. An electromagnetic field enhancement of the magnetic dipole mode induces generation of a harmonic signal by the plurality of structures. Alternatively, a harmonic light-generating metasurface, includes a base substrate, a supporting substrate that includes a nonlinear material, and a plurality of paired structures disposed in a pattern on a surface of the supporting substrate. Each paired structure, of the plurality of paired structures, collectively supports a toroidal dipole mode. An electromagnetic field enhancement of the toroidal dipole mode penetrates the supporting substrate to induce generation of a harmonic signal by the supporting substrate.
    Type: Application
    Filed: October 1, 2019
    Publication date: January 13, 2022
    Applicants: William Marsh Rice University, Academia Sinica
    Inventors: Michael Semmlinger, Ming Lun Tseng, Jian Yang, Ming Zhang, Din Ping Tsai, Liangliang Dong, Arash Ahmadivand, Peter Nordlander, Nancy Jean Halas
  • Publication number: 20220007692
    Abstract: The present disclosure is directed to poly-albumen polymer based edible film for fruit and vegetable preservation and methods for use thereof. This multifunctional bionanocomposite is comprised largely of egg-derived polymers and cellulose nanomaterials as a conformal coating onto fresh produce that slows down food decay by retarding ripening, dehydration, and microbial invasion. The coating is edible, washable, and made from readily available inexpensive or waste materials which makes it a promising economic alternative to commercially available fruit coatings and a solution to combat food wastage that is rampant in the world.
    Type: Application
    Filed: July 12, 2021
    Publication date: January 13, 2022
    Applicant: William Marsh Rice University
    Inventors: Muhammad M. RAHMAN, Seohui JUNG, Neethu POTTACKAL, Pulickel M. AJAYAN
  • Patent number: 11203013
    Abstract: This disclosure describes enantiomerically enriched chiral molecular sieves and methods of making and using the same. In some embodiments, the molecular sieves are silicates or germanosilicates of STW topology.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: December 21, 2021
    Assignees: California Institute of Technology, William Marsh Rice University
    Inventors: Mark E. Davis, Stephen Kramer Brand, Joel E. Schmidt, Michael W. Deem
  • Publication number: 20210386907
    Abstract: Provided herein are peptide-based hydrogels, or neutral multidomain peptide hydrogel (NMDP), as well as uses thereof. The uses include encapsulating cells to induce quiescence for long-term storage and administering to a subject to induce collagen deposition and macrophage infiltration. The disclosed hydrogel is useful for the preservation of stem cells, including maintaining their quiescence and differentiation potential.
    Type: Application
    Filed: October 16, 2019
    Publication date: December 16, 2021
    Applicant: William Marsh Rice University
    Inventors: Jeffrey HARTGERINK, David LEACH, Tania LOPEZ-SILVA
  • Patent number: 11199514
    Abstract: An Electron Paramagnetic resonance (EPR) system and method allows the measurement paramagnetic characteristics of materials in real-time, such as heavy oil, hydrocarbons, asphaltenes, heptane, vanadium, resins, drilling fluid, mud, wax deposits or the like. The EPR systems and methods discussed herein are low cost, small and light weight, making them usable in flow-assurance or logging applications. The EPR sensor is capable of measuring paramagnetic properties of materials from a distance of several inches. In some embodiments, a window will be used to separate the EPR sensor from the materials in a pipeline or wellbore. Since the sensor does need to be in direct contact with the materials, it can operate at a lower temperature or pressure. In other embodiments, the EPR sensor may be placed in the materials.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: December 14, 2021
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Aydin Babakhani, Xuebei Yang