Abstract: A drug delivery system comprising propathenone or lidocaine dissolved in thermoplastic resin is shown to be useful for prolonged release antiahrrythmia medications. More generally, a compound with topical anesthetic and plasticizing properties, or another drug having a similar structures containing an aromatic ring, is dissolved in polymeric material. Extrusion, co-extrusion, coating and diffusion techniques to form orally digestible granules, fibers, films and tubes such as endotracheal tubes, drainage tubes and other medical devices with the material containing drug are disclosed. Diffusion techniques in which the drug diffuses into the thermoplastic is also disclosed. A hydrophobic anesthetic or similar compound such as the base form of lidocaine or propathenone is used which is more soluble in the polymeric material than in water. Prilocaine base and dibucaine base are also used in examples.