Patents Assigned to Richter Gedeon Vegyeszeti Gyar Rt.
  • Process for the production of heparin-containing particulate products
    Patent number: 4518771
    Abstract: A heparin-enriched material capable of long-term storage and particularly adapted for use as a raw material in processes for the extraction of heparin is produced by storing the animal organ material for a period of 0.5 to 15 hours (preferably 4 to 6 hours) at a temperature of 10.degree. to 50.degree. C. (preferably 30.degree. to 50.degree. C.), then injecting steam to effect a heat treatment at a temperature between 75.degree. and 100.degree. C. The heat treatment precipitates heparin-containing aggregate which is filtered from the aqueous phase and dried to a dry substance content of 90 to 95%.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: May 21, 1985
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Istvan Takacs, Gyorgy Kerey, Janos Illes, Peter Rudolf, Pal Gere, Laszlo Czebe, Erzsebet Neszmelyi
  • Resorcin derivatives, process for their preparation and pharmaceutical compositions containing them
    Patent number: 4510338
    Abstract: The invention relates to new resorcin derivatives of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 3 carbon atoms or alkoxy having from one to 3 carbon atoms.According to another aspect of the invention there are provided processes for the preparation of these compounds.The compounds of the formula (I) are pharmacologically active. In particular, they are suitable for the treatment of acute ethanolic intoxication. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: April 9, 1985
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Gyorgy Fekete, Laszlo Szporny, Laszlo Vereczkey, Eva Palosi, Imre Klebovich, Pal Vittay, Sandor Gorog, Istvan Hajdu
  • 4-Hydroxy-benzhydrols, process for their preparation and pharmaceutical compositions containing them
    Patent number: 4508926
    Abstract: The invention relates to new 4-hydroxy-benzhydrols of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms, with the proviso that if R.sub.1 is hydrogen, R.sub.2 is other than hydrogen or a 3-trifluoromethyl group, or if R.sub.1 is a 2-methyl group, R.sub.2 is other than a 5-methyl group.According to another aspect of the invention there are provided processes for the preparation of these compounds.The compounds of the formula (I) are pharmacologically active. In particular, they are suitable for the treatment of acute ethanolic intoxication. Pharmaceutical compositions containing them as active ingredients are also within the scope of the invention.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: April 2, 1985
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Gyorgy Fekete, Laszlo Szporny, Laszlo Vereczkey, Eva Palosi, Imre Klebovich, Pal Vittay, Sandor Gorog, Istvan Hajdu
  • Benzhydrylpiperazine derivatives, process for their preparation and pharmaceutical compositions containing them
    Patent number: 4504481
    Abstract: The invention relates to new benzhydrylpiperazine derivatives of the formula (I) ##STR1## wherein n is 2 or 3, and acid addition salts thereof. According to another aspect of the invention there are provided processes for the preparation of these compounds.The compounds of the formula (I) are pharmacologically active. More particularly, they inhibit the microsomal monooxigenase enzyme system of liver. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: March 12, 1985
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szabolcs Szeberenyi, Laszlo Szporny, Sandor Gorog, Istvan Hajdu
  • N-Desmethyl-N-(allyloxymethyl)-vinblastine and antileukemic and antilymphomic compositions and method of treatment
    Patent number: 4490378
    Abstract: The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl andR.sup.3 is .alpha.-ethyl; orR.sup.4 is hydrogen andR.sup.3 is .beta.-ethyl;R" is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >N.sub.a --CH.sub.2 --O-- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety;R.sup.1 is methoxy andR.sup.2 is acetyl, provided that if R.sup.3 is .alpha.-ethyl and R.sup.4 .beta.-hydroxyl,R.sup.4 is other than ethyl.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: December 25, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Lajos Dancsi, Tibor Keve, Gyorgy Fekete, Eszter Dezseri, Sandor Gorog, Tibor cs, Csaba Szantay, Lajos Szabo, Katalin Honty, Sandor Eckhardt, Ivan Hindi, Sandor Kerpel-Fronius, Zsuzsanna Relle nee Somfa, Janos Sugar
  • Apovincaminic acid esters
    Patent number: 4474960
    Abstract: A process is disclosed for the preparation of racemic cis or trans apovincaminic acid esters of the formula (I) ##STR1## and the corresponding optically active derivatives of the formulae (Ia) ##STR2## wherein R.sup.1 and R.sup.2 are identical or different alkyl groups having 1 to 6 carbon atoms. Apovincaminic acid alkyl esters are well-known vasodilating compounds.
    Type: Grant
    Filed: June 11, 1982
    Date of Patent: October 2, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Janos Kreidl, Laszlo Czibula, Gyorgy Visky, Andras Nemes, Maria Farkas nee Kirlyak
  • Process for the preparation of eburnamonine derivatives
    Patent number: 4464535
    Abstract: The invention relates to a new process for the preparation of eburnamonine derivatives of the general Formula I ##STR1## (wherein R.sup.1 is an alkyl group having 1-6 carbon atoms) and optical and geometrical isomers thereof which comprises reacting a hydroxyimino-octahydro-indolo[2,3-a]quinolizine derivative of the general Formula II ##STR2## (wherein R.sup.1 is as stated above and R.sup.2 stands for an alkyl group having 1-6 carbon atoms being identical with or different from R.sup.1, or a hydrogen atom) or an acid addition salt thereof in an organic protic solvent or solvent mixture with an inorganic base, optionally under the addition of water or an aqueous mineral acid, at a temperature between 60.degree. C. and 200.degree. C.The compounds of the present invention are known drugs having blood pressure decreasing and cerebral vasodilatatory effect.
    Type: Grant
    Filed: November 1, 1982
    Date of Patent: August 7, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Janos Kreidl, Gyorgy Visky, Andras Nemes, Laszlo Czibula, Maria Farkas nee Kirjak
  • Process for the preparation of vincaminic acid esters
    Patent number: 4464534
    Abstract: The invention relates to a new process for the preparation of apovincaminic acid esters. More particularly, the invention concerns a process for preparing racemic and optionally active vincaminic acid esters of the formula (I) ##STR1## in which R.sup.1 and R.sup.2 independently stand for alkyl having from one to 6 carbon atoms, and 14-epimers thereof.According to the invention an octahydroindolo[2,3-a]quinolizine-oxime ester of the formula (II) ##STR2## in which R.sup.1 and R.sup.2 have the same meaning as defined above, is reacted with an aqueous solution of sulfurous acid or a salt thereof at a temperature of 80.degree. to 110.degree. C. and the 14-epimeric mixture obtained is epimerized or separated in a known manner and if desired, the racemic vincaminic acid esters are resolved.
    Type: Grant
    Filed: September 28, 1982
    Date of Patent: August 7, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Janos Kreidl, Andras Nemes, Maria Farkas nee Kirjak, Gyorgy Visky, Laszlo Czibula
  • 9-Bromo-hexahydro- and octahydro-indolo[2,3 a]quinolizines and use for increasing blood circulation
    Patent number: 4456607
    Abstract: New salts of the formula XIIIa and XIIIb are disclosed ##STR1## wherein R.sup.2, R.sup.3 and R.sup.5 are each C.sub.1 to C.sub.6 alkyl and A.sup.- is an anion of a pharmaceutically acceptable acid. Furthermore new compounds of the formula XIVa and XIVb are disclosed: ##STR2## wherein R.sup.2 and R.sup.3 are as defined above. The new salts and compounds are intermediates in the preparation of 10-bromo-vincaminic acid esters. In addition the new salts and compounds have the ability to increase blood circulation and to decrease blood flow resistance in an animal subject while at the same time maintaining a steady pulse rate and blood pressure.
    Type: Grant
    Filed: June 2, 1981
    Date of Patent: June 26, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Lajos Dancsi, Tibor Keve, Egon Karpati, Laszlo Szporny
  • 3-Chloro-pregnane derivatives and a process for the preparation thereof
    Patent number: 4456601
    Abstract: New .DELTA..sup.1,3,5 -3-chloro-pregnane derivatives of the general formula (I), ##STR1## wherein X is hydrogen atom, acetyl group or a chloroacetyl group, andY and Z represent hydrogen atom or a halogen atom, with the proviso that at least one of them is other than hydrogen,are prepared by reacting a .DELTA..sup.1,4 -3-oxo-pregnane derivative of the general formula (II), ##STR2## wherein X' is acetyl group or a chloroacetyl group and Y and Z are as defined above, with a chloromethyleneiminium salt of the general formula (III), ##STR3## wherein A.sup.(-) is a salt-forming anion, in an aprotic solvent in the presence of a tertiary base, and, if desired, subjecting the resulting product to hydrolysis.The compounds of the general formula (I) exert antiphlogistic effects and can be used in the therapy for the treatment of inflammations.
    Type: Grant
    Filed: October 14, 1982
    Date of Patent: June 26, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Jozsef Toth, Gyorgy Hajos, Gyorgy Fekete, Istvan Horvath, Laszlo Szporny, Anna Boor nee Mezei, Peter Aranyi, Aniko Naray, Sandor Gorog, Sandor Holly, Csaba Molnar
  • 3,7-Diazabicyclo [3.3.1] nonanes having anti-arrhythmic activity
    Patent number: 4451473
    Abstract: New bicyclic compounds of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2 each represent a C.sub.1-6 alkyl group, andR.sup.3 is an etherified hydroxy group of the formula --CR.sup.4, wherein R.sup.4 is benzyl group, benzhydryl group or a phenyl group bearing optionally a phenyl or a trihalomethyl substituent or one or more halogen substituent(s), orR.sup.3 is an esterified hydroxy group of the formula --OCO--R.sup.5, which representsa phenyl-(C.sub.1-5 alkyl)-carbonyloxy group,a cinnamoyloxy group having optionally a halogen or one or more C.sub.1-4 alkoxy substituent(s),a benzoyloxy group having optionally a C.sub.1-4 alkyl, phenyl or trihalomethyl substituent or one or more C.sub.
    Type: Grant
    Filed: July 16, 1982
    Date of Patent: May 29, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Karoly Nador, Gabor Kraiss, Katalin Sinko, Margit Paroczai, Egon Karpati, Laszlo Szporny
  • Apparatus for producing tempered plate parts
    Patent number: 4450608
    Abstract: An apparatus for producing tempered plate spare parts, planar shaped products, shear platus, blades cut from band material, and particularly ampule files, comprises a band hobbing and feeding unit, in certain cases a mechanical forming unit, particularly a serrating and/or sharpening unit, a heating and cooling unit and a cutting mechanism. The apparatus is equipped with a cutting-cooling mechanism arranged on a cross slide that can alternately be displaced crosswise to the transfer trace of the band material and it is provided with pairs of cutting tools arranged in two parallel or approximately parallel--expediently flat--clamp plates that can be pressed to one another.
    Type: Grant
    Filed: June 18, 1982
    Date of Patent: May 29, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Janos Balazs, Tibor Bano, Arpad Kollar, Tibor Kovacs, Denes Lengyel, Ferenc Mozer
  • Heterocyclic compounds containing an alkoxycarbonyl and a substituted methyl group
    Patent number: 4435322
    Abstract: The invention relates to new heterocyclic compound containing an alkoxycarbonyl and a substituted methyl group a process for the preparation of these and analogeous compound and pharmaceutical compositions containing them.More particularly, the invention concerns compounds of the general formula (IVa) ##STR1## wherein R' is hydrogen, 2-ethoxycarbonylethyl, aryl or a group suitable for a temporary protection of amides andY' represents a group of the formula --COOZ or --CH.sub.2 M, in whichZ is lower alkyl andM is hydroxyl, halogen, cyano or a group of the formula --O--SO.sub.2 R.sup.2, in whichR.sup.2 is lower alkyl or aryl,with the proviso that if R' is phenyl, Y' cannot stand for the group --COOC.sub.2 H.sub.5.The invention further relates to a process for the preparation of compounds of the general formula (IV) ##STR2## in which R and Y are identical with R' and Y', respectively, except the proviso.
    Type: Grant
    Filed: September 11, 1981
    Date of Patent: March 6, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Karoly Lempert, Kalman Harsanyi, Gabor Doleschall, Gyula Hornyak, Jozsef Nyitrai, Karoly Zauer, Jozsef Fetter, Gyula Simig, Zsuzsanna Visky nee Gombos, Gizella Barta nee Szalai
  • Beta-lactam compounds containing a protected C-acetyl group, process for their preparation and pharmaceutical compositions containing them
    Patent number: 4434099
    Abstract: The invention relates to new heterocyclic compounds containing a protected C-acetyl group. More particulary, the invention concerns new compounds of the formula (VI) ##STR1## wherein R.sup.1 is hydrogen or a group suitable for a temporary protection or amides,X is hydroxyl, halogen, cyano or an --O--SO.sub.2 --R.sup.2 group, in whichR.sup.2 is lower alkyl or aryl,Y.sup.1 and Y.sup.2 together form a group suitable for a temporary protection of a keto group.The new compounds possess anaphylactic properties and are valuable intermediates of thienamycin synthesis. Their preparation and the new intermediates obtained during their preparation are also within the scope of the invention.
    Type: Grant
    Filed: September 11, 1981
    Date of Patent: February 28, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Karoly Lempert, Kalman Harsanyi, Gabor Doleschall, Gyula Hornyak, Jozsef Nyitrai, Karoly Zauer, Jozsef Fetter, Gyula Simig, Zsuzsanna Gombos nee Visky, Gizella Szalai nee Barta
  • Beta-lactam compounds containing a C-acetal group and process for their preparation
    Patent number: 4432901
    Abstract: The invention relates to new heterocyclic compounds containing a C-acetyl group and a process for their preparation. More particularly, the invention concerns new compounds of the formula (III). ##STR1## in which R is a protecting group suitable for temporary protection of amines and amides or an aryl group, and Z is alkyl.The compounds are intermediates in the preparation of penicillins.
    Type: Grant
    Filed: September 11, 1981
    Date of Patent: February 21, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Karoly Lempert, Kalman Harsanyi, Gabor Doleschall, Gyula Hornyak, Jozsef Nitrai, Karoly Zauer, Jozsef Fetter, Gyula Simig, Zsuzsanna Visky nee Gombos, Gizella Barta nee Szalai
  • Polycyclic compounds substituted on the A-ring, pharmaceutical compositions containing them, and methods of treating psoriasis with them
    Patent number: 4432982
    Abstract: The invention relates to new polycyclic compounds substituted on the A-ring. More particularly, the invention concerns new polycyclic compounds of the formula (I) ##STR1## wherein R.sup.1 is methoxy or halogen andR.sup.2 is hydrogen; orR.sup.1 is hydrogen andR.sup.2 is halogen and acid addition salts thereof.
    Type: Grant
    Filed: February 4, 1982
    Date of Patent: February 21, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Mari Zajer nee Balazs, Lilla Forgach, Egon Karpati, Arpad Kiraly, Gyongyver Kiraly nee Soos, Laszlo Szporny, Bela Rosdy
  • Process for the preparation of a selective anorexogenic substance regulating food intake
    Patent number: 4430264
    Abstract: A process is disclosed for the preparation of an endogenous anorexogenic substance obtained from blood serum. The anorexogenic substance itself is also described having a specific activity of 100 units/mg.
    Type: Grant
    Filed: September 28, 1982
    Date of Patent: February 7, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Jozsef Knoll, Janos Nagy
  • Cis-10-bromo-E-homoeburnanes
    Patent number: 4428877
    Abstract: A novel process for preparing 10-bromo-vincaminic acid esters and homologous compounds of the general formula ##STR1## wherein R.sup.1 and R.sup.2 each stand for a C.sub.1-6 alkyl group is disclosed.All the intermediate products are new and exhibit valuable therapeutical effect on the blood circulation.
    Type: Grant
    Filed: February 13, 1981
    Date of Patent: January 31, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Lajos Dancsi, Tibor Keve, Egon Karpati, Laszlo Szporny
  • 1.alpha.-Ethyl-1.beta.-(2'-alkoxy carbonyl-2'-hydroxyiminoethyl)-10-methoxy 1,2,3,4,6,7,12,12.beta.-octahydroindolo(2,3A)quinolizines
    Patent number: 4429129
    Abstract: The invention relates to a new process for the preparation of alkoxyvincaminic acid esters of the formula (I) ##STR1## and/or alkoxyapovincaminic acid esters of the formula (II) ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 independently stand for alkyl groups having from one to 6 carbon atoms.The compounds of the formulae (I) and (II) are pharmaceutically active, thus some of them show psychostimulant activity.
    Type: Grant
    Filed: August 20, 1982
    Date of Patent: January 31, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt
    Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Tibor Keve, Lajos Dancsi, Janos Galambos, Ferenc Vezekenyi, Tibor Acs
  • Peptides affecting the immune regulation and a process for their preparation
    Patent number: 4428938
    Abstract: Peptides affecting the immune regulation selected from the following group:Arg-Lys-AspArg-Lys-Asp-ValArg-Lys-Asn-ValArg-Lys-Asu-ValArg-Lys-Ala-ValArg-Lys-Asp-AlaArg-Lys-Asp-IleArg-Lys-Glu-ValArg-Ala-Asp-ValArg-Asp-Lys-ValAla-Lys-Asp-ValLys-Arg-Asp-ValGlp-Arg-Lys-AspGlp-Arg-Lys-Asp-ValGlp-Arg-Lys-Asp-Val-Tyr and salts, amides lower alkyl esters and protected derivatives thereof.
    Type: Grant
    Filed: June 11, 1982
    Date of Patent: January 31, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Lajos Kisfaludy, Olga Nyeki nee Kuprina, Istvan Schon, Laszlo Denes, Julia Ember, Gyorgy Hajos, Laszlo Szporny, Bela Szende