Abstract: For measuring quality of view over a visual field of view of an eye, during a measuring period, deviations between gaze positions and associated stimulus positions where the stimulus to be followed was displayed when the gaze position was detected and magnitudes of the registered deviations arte determined. For each field portion of a map of a visual field of view, quality of view is determined in accordance with a quality of view estimates of associated ones of the registered deviations of which the associated stimulus positions are located relative to the gaze position so that the associated stimulus positions are in that field portion. For each of the associated ones of the registered deviations, the quality of view is estimated in accordance with the magnitude of that associated one of the registered deviations and with magnitudes of at least preceding or succeeding ones of the registered deviations.

Abstract: The present invention relates to novel arginase inhibitors of formula (I). These novel compounds are useful in the treatment of diseases that are associated with arginase activity, such as asthma, allergic rhinitis and COPD (chronic obstructive pulmonary disease).

Abstract: The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to investigate cell-material interactions. Provided is a cell culture system having a biomaterial substrate which has at least a first linear surface gradient oriented orthogonally to a second linear surface gradient, wherein the first gradient and the second gradient are selected from the group consisting of stiffness (S), (aligned) topography (T) and wettability (W). Also provided is a cell screening platform having a combination of at least two, preferably at least three, more preferably four distinct cell culture systems.

Abstract: The present invention relates to anti-CD 103 antibodies, as well as use of these antibodies in diagnosis, prognosis, monitoring, and treatment of diseases. Also disclosed is an imaging agent comprising the anti-CD 103 antibody and a detectable label, wherein the antibody either does not block CD 103 binding to E-cadherin or at least partially blocks CD 103 binding to E-cadherin. The methods of treatment involve administering the anti CD 103 antibody which may be optionally coupled to a cytotoxic agent. Diseases to be treated include e.g. Hairy Cell leukemia, HCLv, intestinal and extraintestinal lymphomas, enteropathy-associated T-cell lymphoma (EATL), T-lymphoblastic leukemia/lymphoma (T-ALL), T-cell prolymphocytic leukemia (T-PLL), adult T cell leukemia/lymphoma (ATLL), mycosis fungoides (ME), anaplastic large cell lymphoma ALCL, cutaneous T-cell lymphoma (CTCL), Sezary Syndrome (SS), Alzheimer's disease, Parkinson's disease or multiple sclerosis.

Abstract: A computer program product for gathering respondent input for determining a ranking of states each characterized by a set of selected levels each associated to an attribute. The interface mechanism provides for inputting selected attribute levels of a respondent state and for ranking of comparable alternative states determined in response to the inputted respondent state, in comparison with that respondent state. The alternative states are each displayed as the set of attributes with the associated set of alternative levels simultaneously and with an input field for inputting a preference indication of the shown alternative state compared with the respondent state. This allows the respondent input to be entered with very few input actions and little switching between screens. Only the selected attribute levels of the respondent state and the rankings and identifications of the determined alternative states need to be transmitted to the central computer.

Abstract: A method for the in situ derivatization of at least one biogenic amine, precursor, or metabolite thereof in an isolated aqueous sample includes the steps of: (i) contacting the sample with a propionic anhydride/acetonitrile solution in the presence of a phosphate buffer having a pH in the range of 7.0 to 9.0 and allowing the conversion of amine and/or hydroxyl moieties of the biogenic amine, precursor, or metabolite thereof to form a propionyl derivative of the biogenic amine; followed by (ii) adding to the reaction mixture obtained in step (i) a carbodiimide compound and an electrophilic amine-containing compound, and allowing the carbodiimide-mediated derivatization of carboxylic acid moieties of the biogenic amine, precursor, or metabolite thereof.

Abstract: The invention relates generally to the field of nanopores and the use thereof in various applications, such as analysis of biopolymers and macromolecules, typically by making electrical measurements during translocation through a nanopores. Provided is a system comprising a funnel-shaped proteinaceous nanopore comprising an a-helical pore-forming toxin that is a member from the actinoporin protein family, more in particular Fragaceatoxin C (FraC), a mutant FraC, a FraC paralog, or a FraC homolog.

Abstract: A method for detecting an analyte in a sample includes the steps of obtaining a nanopore sensor comprising a nanopore and a protein adaptor internalized in the lumen of the nanopore, adding a sample comprising an analyte to the cis side or the trans side of the nanopore, and measuring conductance across the nanopore. A change in conductance after adding the sample indicates the analyte is present in the sample and has bound to the protein adaptor. Nanopore sensors comprise a nanopore and a protein adaptor internalized in the lumen of the nanopore. The protein adaptor is a functional enzyme or ligand-binding protein.

Abstract: A method for the in situ derivatization of at least one biogenic amine, precursor, or metabolite thereof in an isolated aqueous sample includes the steps of: (i) contacting the sample with a propionic anhydride/acetonitrile solution in the presence of a phosphate buffer having a pH in the range of 7.0 to 9.0 and allowing the conversion of amine and/or hydroxyl moieties of the biogenic amine, precursor, or metabolite thereof to form a propionyl derivative of the biogenic amine; followed by (ii) adding to the reaction mixture obtained in step (i) a carbodiimide compound and an electrophilic amine-containing compound, and allowing the carbodiimide-mediated derivatization of carboxylic acid moieties of the biogenic amine, precursor, or metabolite thereof.

Abstract: A sensor cartridge contains a porous matrix for passing analyte molecules of a liquid sample. A porous collection disk supports the matrix and closes a lower end of a wall of the cartridge. The collection disk being sandwiched between the lower end and a base cap. An air channel extends between a first air opening at a top end of the cartridge and a second air opening positioned above the collection disk and opposite a base cap air opening. The collection disk is between the second air opening and the base cap air opening. At least one of the first air openings and the base cap air opening comprises a connection to a supra-atmospheric or subatmospheric pressure air source. The second air opening and the base cap air opening guide an air flow to provide evaporation and analyze concentration at specific locations of the collection disk, thereby improving detection limits.

Abstract: The invention relates to methods, reagents and kits for detecting the susceptibility to cervical cancer. In particular, it relates to novel methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3 (CIN2/3) and the use thereof for identifying a cervical cell as neoplastic or predisposed to neoplasia in an isolated sample.

Abstract: The invention is directed to a method and a surgical instrument, typically a surgical stapler that is configured for performing anastomosis of a first gastro-intestinal tract section to a second gastro-intestinal tract section, both gastro-intestinal tract sections comprising a superficial layer and an intermediate layer. Said method comprises contacting the superficial layers of said gastro-intestinal tract sections and compressing the contacted sections between a first pressure area and a second pressure area, wherein the sum of the first pressure area and the second pressure increases during the compression such that the superficial layers are pressed aside and the intermediate layers are contacted.

Abstract: A method for detecting an analyte in a sample includes the steps of obtaining a nanopore sensor comprising a nanopore and a protein adaptor internalized in the lumen of the nanopore, adding a sample comprising an analyte to the cis side or the trans side of the nanopore, and measuring conductance across the nanopore. A change in conductance after adding the sample indicates the analyte is present in the sample and has bound to the protein adaptor. Nanopore sensors comprise a nanopore and a protein adaptor internalized in the lumen of the nanopore. The protein adaptor is a functional enzyme or ligand-binding protein.

Abstract: The invention provides an underwater energy storage system (UW-ES system) comprising a reservoir structure (5), which is resting at the bottom (4) of a waterbody (1), such as a sea, an ocean, a waterway, etc. The reservoir structure has a pressurizing reservoir (7A, 7B) with a deformable wall structure (17A, 17B) and a depressurizing reservoir (8A, 8B) with a rigid wall structure (6, 14, 18A, 18B), which are holding a working liquid (9) separated from the water (2) of the water body. Energy is stored and retrieved by displacing part of the working liquid from the depressurizing reservoir into the pressurizing reservoir, and vice versa, respectively. Therein use is made of the hydrostatic pressure of the water (2) acting on the deformable wall structure of the pressurizing reservoir. The UW-ES system is compact and economical, and allows for highly synergistical integration with various power take-off systems.

Abstract: A method for reclaiming rubber comprises the steps of: (i) providing a starting material comprising a vulcanized rubber polymer; (ii) subjecting the starting material to mechanical stress and at a temperature of at least 200° C. to achieve at least a partial destruction of the cross-links and the backbone structure of the rubber polymer into fragments; and (iii) reconstituting at least part of the fragments in the presence of a branching/grafting agent to obtain a renewed rubber composition.

Abstract: The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to investigate cell-material interactions. Provided is a cell culture system having a biomaterial substrate which has at least a first linear surface gradient oriented orthogonally to a second linear surface gradient, wherein the first gradient and the second gradient are selected from the group consisting of stiffness (S), (aligned) topography (T) and wettability (W). Also provided is a cell screening platform having a combination of at least two, preferably at least three, more preferably four distinct cell culture systems.

Abstract: Sensor cartridge comprising a wall having an open top end and a lower end and enclosing a space containing porous matrix. The porous matrix is configured for passing analyte molecules of a liquid sample therethrough. A porous collection disk supports and contacts the porous matrix and closes the lower end of the wall. A base cap is attached to the lower end such that the collection disk is sandwiched between the lower end of the wall and the base cap. The sensor cartridge comprises an air channel extending between a first air opening positioned at a top end thereof and a second air opening positioned at a distance above the collection disk. The base cap comprises a base cap air opening positioned opposite the second air opening. The collection disk is positioned between the second air opening and the base cap air opening.

Abstract: The invention is directed to an adhesive complex coacervate composition, to a method of physically crosslinking an adhesive complex coacervate composition, to a method for adhering a tissue defect in a subject, and to the use of an adhesive complex coacervate composition. The adhesive complex coacervate composition of the invention comprises a polycation and a polyanion, wherein said polycation and polyanion together comprise on average at least two thermoresponsive moieties per polymer chain, said thermoresponsive moieties exhibiting a lower critical solution temperature, wherein said polycation comprises 5-70 mol % of thermoresponsive moieties and/or wherein said polyanion comprises 5-70 mol % of thermoresponsive moieties, and wherein said polycation and/or said polyanion is a graft or block copolymer comprising said thermoresponsive moieties.

Abstract: The present invention relates generally to the production of steviol glycosides. Provided is a method for enzymatically providing a modified steviol glycoside, comprising incubating a steviol glycoside substrate in the presence of sucrose and the glucansucrase GTF180 of Lactobacillus reuteri strain 180, or a mutant thereof having the desired transglycosylation activity. Also provided are modified steviol glycosides obtainable by a method of the invention, and the use thereof as low-glycemic sweetener.

Abstract: A method for producing a porous metallic structure comprising a metal element from a metal salt comprising a cation part and an anion part, comprising the steps of: providing a volume of metal salt; exposing the volume of metal salt in an atmosphere comprising a reduction gas at a temperature below a melting temperature of the metal element, leading to converting the volume of metal salt into the porous metallic structure by removing the anion part using the reduction gas; wherein the porous metallic structure has a pore size between 1 nanometer and 50 micrometer, and a ligament size between 1 nanometer and 50 micrometer; wherein the ligament size is controlled by the temperature during the exposing.