Patents Assigned to Rijksuniversiteit Limburg
  • Method for the extraction of a vitamin-K-dependent carboxylase complex and the use thereof
    Patent number: 5100798
    Abstract: Method for the extraction and insolubilization of a vitamin-K-dependent carboxylase complex from biological material, for instance a bovine liver homogenate, which can be used for the conversion of, for example, precursors of the blood coagulation factors II, VII, X and especially IX prepared via recombinant DNA-technology, the insolubilized carboxylase complex, as well as the prepared biologically active blood coagulation factors to be used in pharmaceutical compositions.
    Type: Grant
    Filed: October 27, 1987
    Date of Patent: March 31, 1992
    Assignee: Rijksuniversiteit Limburg
    Inventors: Cornelis Vermeer, Berry A. M. Soute