Abstract: The invention provides methods of identifying drug targets in dopaminergic and/or noradrenergic neurons and to the drug targets identified by such methods. This invention also provides a method of screening for agents that modulate dopaminergic neurons and/or noradrenergic neuron activity, function and/or drug target expression, and agents that bind drug targets and to kits for use in the methods described herein.
Abstract: The invention features methods and compositions for preventing or treating post-surgical pain by administering an anti-NGF antagonist antibody.
Abstract: The invention features methods and compositions for preventing or treating pain resulting from surgery or an incision by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.
Abstract: This invention relates to the field of taxol-induced gut disorder. More specifically, the invention relates to methods of treating taxol-induced gut disorder comprising administration of agonist anti-trkC antibody for the treatment, prevention, and/or amelioration of a symptom of taxol-induced gut disorder.