Patents Assigned to Riom Laboratories C.E.R.M.
  • Patent number: 4820702
    Abstract: Compounds of formula: ##STR1## in which R and R' denote an alkyl radical having 1 to 7 carbon atoms; R.sub.1 denotes hydrogen or an alkyl radical having 1 to 7 carbon atoms; and R.sub.2 and R.sub.3 denote, separately, an alkyl radical having 1 to 7 carbon atoms or a phenyl radical, or, together with the carbon atom to which they are attached, a cycloalkyl radical having at most 7 carbon atoms; n may assume the values 2 or 3; and their pharmaceutically acceptable salts.Application as a cardiovascular medicinal product.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: April 11, 1989
    Assignee: Riom Laboratories C.E.R.M.
    Inventors: Patrick Carlier, Jacques A. Simond, Andre J. Monteil
  • Patent number: 4803219
    Abstract: N,N-dimethyl-N'-benzoyl-N'-(2,3-dihydrobenzofuran-2-ylmethyl)1,3-propanedia mine of formula: ##STR1## and its pharmaceutically acceptable salts, in racemic form or in the form of enantiomers, which compounds have anti-arrhythmic properties.
    Type: Grant
    Filed: July 21, 1987
    Date of Patent: February 7, 1989
    Assignee: RIOM Laboratories C.E.R.M.
    Inventors: Michel Combourieu, Nadine Simbille, Marie-Paule Landes, Yvon Bernet
  • Patent number: 4668679
    Abstract: The invention relates to compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, in which X represents either --CH.dbd. or --N.dbd., R.sub.1 represents an alkyl radical having 1 to 5 carbon atoms, R.sub.2 represents hydrogen and R.sub.3 is an alkyl radical having 1 to 5 carbon atoms, or R.sub.2 and R.sub.3, together with the nitrogen atom to which they are bonded, represent a heterocyclic radical, such as pyrrolidinyl, morpholino, 4-phenyl-piperazinyl, in which the phenyl radical can carry one or more substituents, such as a halogen atom, an alkyl or alkoxy radical having 1 to 5 carbon atoms or the trifluoromethyl radical, or represents 4-(2-pyrimidinyl)-piperazinyl, having anti-bronchoconstrictory properties.
    Type: Grant
    Filed: December 24, 1985
    Date of Patent: May 26, 1987
    Assignee: Riom Laboratories C.E.R.M.
    Inventors: Jacques A. L. Simond, Patrick Carlier, Andr/e/ J. Monteil
  • Patent number: 4631277
    Abstract: The invention is dealing with antispasmodic compounds of the formula I ##STR1## in which R.sub.1 denotes H, halogen or a linear or branched C.sub.1 to C.sub.3 alkoxy or alkyl group, R.sub.2, R.sub.3 and R.sub.4 separately denote a linear or branched C.sub.1 to C.sub.4 alkyl group or R.sub.2 and R.sub.3 together with the nitrogen atom to which they are bound form a saturated heterocyclic radical, Z denotes a linear or branched C.sub.1 to C.sub.6 alkylene group and X.sup.- denotes an anion, preferably a halogen ion,and is dealing with intermediates in the preparation of the compounds of formula I.
    Type: Grant
    Filed: July 11, 1985
    Date of Patent: December 23, 1986
    Assignee: Riom Laboratories C.E.R.M. "RL-C.E.R.M." S.A.
    Inventors: Michel Combourieu, Yvon Bernet, Jean-Claude Laigle, Nadine Simbille