Patents Assigned to Ripple Therapeutics Corporation
  • Ocular inserts comprising a covalently linked steroid dimer
    Patent number: 11612567
    Abstract: The disclosure relates to compounds and compositions for sustained release of ocular therapeutics.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: March 28, 2023
    Assignee: RIPPLE THERAPEUTICS CORPORATION
    Inventors: Ian Charles Parrag, Matthew Alexander John Statham, Kyle Battiston, Dimitra Louka, Wendy Alison Naimark, Hans Christian Fischer, Leonard Pinchuk
  • Intravitreal injector
    Patent number: 11464914
    Abstract: Provided herein are needle assemblies for intravitreal injection of an implant into an eye of a patient through an unsheathed state and a sheathed state. Such needle assemblies are precise and accurate for proper treatment and prevent further damage to the eye.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: October 11, 2022
    Assignee: RIPPLE THERAPEUTICS CORPORATION
    Inventors: Ian Parrag, Hans Fischer, Dimitra Louka, Jared A. Demorat, Robert William Henson, Eli B. Nichols
  • Heterodimer compositions and methods for the treatment of ocular disorders
    Patent number: 11279729
    Abstract: Described herein are processable compositions comprising at least one moiety that is processable in its free form. Also described herein are compositions and methods for the treatment of ocular diseases or disorders including glaucoma, blepharitis, ocular inflammation, diabetic macular edema, posterior inflammation, anterior inflammation, macular degeneration (e.g., wet macular degeneration (AMD) or dry AMD), post-cataract surgery, and retinal vein occlusion. Said compositions and methods comprise steroids and prostaglandins which demonstrate anti-inflammatory activity, intraocular pressure (IOP) lowering, and/or other desirable activities. Injection of said compositions in the eye provides therapeutic benefit to patients suffering from ocular disorders.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: March 22, 2022
    Assignee: RIPPLE THERAPEUTICS CORPORATION
    Inventors: Ian Charles Parrag, Wendy Alison Naimark, Matthew Alexander John Statham, Georgios Rizis, Kyle Giovanni Battiston
  • Dexamethasone prodrug compositions and uses thereof
    Patent number: 10959954
    Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: March 30, 2021
    Assignee: RIPPLE THERAPEUTICS CORPORATION
    Inventors: Ian Charles Parrag, Matthew Alexander John Statham, Kyle Battiston, Dimitra Louka, Hans Christian Fischer, J. Paul Santerre, Wendy Alison Naimark, Roseita Esfand
  • Dexamethasone prodrug compositions and uses thereof
    Patent number: 10945958
    Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: March 16, 2021
    Assignee: RIPPLE THERAPEUTICS CORPORATION
    Inventors: Ian Charles Parrag, Matthew Alexander John Statham, Kyle Battiston, Dimitra Louka, Hans Christian Fischer, J. Paul Santerre, Wendy Alison Naimark
  • Glass formulations and uses thereof
    Patent number: 10632075
    Abstract: The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: April 28, 2020
    Assignee: Ripple Therapeutics Corporation
    Inventors: Ian Charles Parrag, Matthew Alexander John Statham, Kyle Battiston, Dimitra Louka, Hans Christian Fischer, J. Paul Santerre, Wendy Alison Naimark
  • Dexamethasone prodrug compositions and uses thereof
    Patent number: 10588862
    Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: March 17, 2020
    Assignee: Ripple Therapeutics Corporation
    Inventors: Ian Charles Parrag, Matthew Alexander John Statham, Kyle Battiston, Dimitra Louka, Hans Christian Fischer, J. Paul Santerre, Wendy Alison Naimark