Patents Assigned to RM2 TECHNOLOGY LLC
  • Patent number: 12209318
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: January 28, 2025
    Assignee: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Publication number: 20240065749
    Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.
    Type: Application
    Filed: November 6, 2023
    Publication date: February 29, 2024
    Applicants: Inter Science GmbH, RM2 Technology LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky, Michael Klaus Stehling, Enric Günther
  • Patent number: 11866833
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes for electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: January 9, 2024
    Assignee: RM2 Technology LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Patent number: 11857244
    Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: January 2, 2024
    Assignees: Inter Science GmbH, RM2 Technology LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky, Michael Klaus Stehling, Enric Günther
  • Publication number: 20220105256
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Patent number: 11260165
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: March 1, 2022
    Assignee: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Patent number: 11229734
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: January 25, 2022
    Assignee: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Patent number: 11123475
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes for electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: September 21, 2021
    Assignee: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Publication number: 20210220532
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes for electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Application
    Filed: April 2, 2021
    Publication date: July 22, 2021
    Applicant: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Publication number: 20210186592
    Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.
    Type: Application
    Filed: March 8, 2021
    Publication date: June 24, 2021
    Applicants: INTER SCIENCE GMBH, RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky, Michael Klaus Stehling, Enric Günther
  • Patent number: 10939949
    Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: March 9, 2021
    Assignees: INTER SCIENCE GMBH, RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky, Michael Klaus Stehling, Enric Günther
  • Publication number: 20190357960
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes for electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Application
    Filed: July 11, 2019
    Publication date: November 28, 2019
    Applicant: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Patent number: 10390874
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes the electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: August 27, 2019
    Assignee: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Publication number: 20190117291
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 25, 2019
    Applicant: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Patent number: 10154873
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used the treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: December 18, 2018
    Assignee: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Publication number: 20180193082
    Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.
    Type: Application
    Filed: May 13, 2015
    Publication date: July 12, 2018
    Applicants: INTER SCIENCE GMBH, RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky, Michael Klaus Stehling, Enric Günther
  • Publication number: 20160296269
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes the electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Application
    Filed: November 14, 2014
    Publication date: October 13, 2016
    Applicant: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Publication number: 20160287867
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used the treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Application
    Filed: November 14, 2014
    Publication date: October 6, 2016
    Applicant: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky