Patents Assigned to RM2 TECHNOLOGY LLC
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Patent number: 12209318Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.Type: GrantFiled: December 16, 2021Date of Patent: January 28, 2025Assignee: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Publication number: 20240065749Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.Type: ApplicationFiled: November 6, 2023Publication date: February 29, 2024Applicants: Inter Science GmbH, RM2 Technology LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky, Michael Klaus Stehling, Enric Günther
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Patent number: 11866833Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes for electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.Type: GrantFiled: April 2, 2021Date of Patent: January 9, 2024Assignee: RM2 Technology LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Patent number: 11857244Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.Type: GrantFiled: March 8, 2021Date of Patent: January 2, 2024Assignees: Inter Science GmbH, RM2 Technology LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky, Michael Klaus Stehling, Enric Günther
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Publication number: 20220105256Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.Type: ApplicationFiled: December 16, 2021Publication date: April 7, 2022Applicant: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Patent number: 11260165Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.Type: GrantFiled: December 13, 2018Date of Patent: March 1, 2022Assignee: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Patent number: 11229734Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.Type: GrantFiled: December 13, 2018Date of Patent: January 25, 2022Assignee: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Patent number: 11123475Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes for electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.Type: GrantFiled: July 11, 2019Date of Patent: September 21, 2021Assignee: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Publication number: 20210220532Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes for electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.Type: ApplicationFiled: April 2, 2021Publication date: July 22, 2021Applicant: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Publication number: 20210186592Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.Type: ApplicationFiled: March 8, 2021Publication date: June 24, 2021Applicants: INTER SCIENCE GMBH, RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky, Michael Klaus Stehling, Enric Günther
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Patent number: 10939949Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.Type: GrantFiled: May 13, 2015Date of Patent: March 9, 2021Assignees: INTER SCIENCE GMBH, RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky, Michael Klaus Stehling, Enric Günther
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Publication number: 20190357960Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes for electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.Type: ApplicationFiled: July 11, 2019Publication date: November 28, 2019Applicant: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Patent number: 10390874Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes the electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.Type: GrantFiled: November 14, 2014Date of Patent: August 27, 2019Assignee: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Publication number: 20190117291Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.Type: ApplicationFiled: December 13, 2018Publication date: April 25, 2019Applicant: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Patent number: 10154873Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used the treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.Type: GrantFiled: November 14, 2014Date of Patent: December 18, 2018Assignee: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Publication number: 20180193082Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.Type: ApplicationFiled: May 13, 2015Publication date: July 12, 2018Applicants: INTER SCIENCE GMBH, RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky, Michael Klaus Stehling, Enric Günther
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Publication number: 20160296269Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes the electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.Type: ApplicationFiled: November 14, 2014Publication date: October 13, 2016Applicant: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
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Publication number: 20160287867Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used the treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.Type: ApplicationFiled: November 14, 2014Publication date: October 6, 2016Applicant: RM2 TECHNOLOGY LLCInventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky