Patents Assigned to RNA, INC.
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Patent number: 10676708Abstract: The present disclosure relates to a method for preparing an aglycone or hydrolyzed glycoside converted from a glycoside and, specifically, to a method for preparing an aglycone or hydrolyzed glycoside from a glycoside by converting a glycoside into an aglycone form or hydrolyzed glycoside by using a microorganism producing ?-glycosidase, and then recovering the aglycone or hydrolyzed glycoside accumulated in the cells of the microorganism.Type: GrantFiled: September 30, 2015Date of Patent: June 9, 2020Assignee: RNA INC.Inventors: Dae Kyun Chung, Hangeun Kim, Seung Su Lee, Bong Jun Jung, Hye Rim Kim, Yoon Doo Lee, Jae Yeon Park, Boram Jeon, Seong Jae Kim
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Publication number: 20170306289Abstract: The present disclosure relates to a method for preparing an aglycone or hydrolyzed glycoside converted from a glycoside and, specifically, to a method for preparing an aglycone or hydrolyzed glycoside from a glycoside by converting a glycoside into an aglycone form or hydrolyzed glycoside by using a microorganism producing ?-glycosidase, and then recovering the aglycone or hydrolyzed glycoside accumulated in the cells of the microorganism.Type: ApplicationFiled: September 30, 2015Publication date: October 26, 2017Applicant: RNA INC.Inventors: Dae Kyun Chung, Hangeun Kim, Seung Su Lee, Bong Jun Jung, Hye Rim Kim, Yoon Doo Lee, Jae Yeon Park, Boram Jeon, Seong Jae Kim
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Publication number: 20130071501Abstract: The present invention relates to an extract of Stewartia koreana and use thereof More particularly, it relates to an extract of Stewartia koreana which is extracted with any one selected from the group consisting of water, a C1-4 low alcohol, a polar solvent, a non-polar solvent and a mixture thereof, and a pharmaceutical composition for promoting angiogenesis or tissue regeneration and a cosmetic for improving wrinkles comprising the same as an effective ingredient. The extract of Stewartia koreana promotes migration and multiplication of endothelial cell and shows excellent effect in angiogenesis and wound healing and is useful in treatment or prevention of diseases which requires angiogenesis for healing of wounded and frostbitten region, wound healing after surgical operation, and treatment and prevention of gastric ulcer, ischaemic heart diseases and hair loss.Type: ApplicationFiled: March 22, 2012Publication date: March 21, 2013Applicant: RNA, INC.Inventors: Ji Young KIM, Dae Kyun CHUNG, Tae Hoon LEE, Guy Wilhem LEE, Jung Min LEE
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Publication number: 20130065947Abstract: The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of PAR4, in particular, by targeting natural antisense polynucleotides of PAR4. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PAR4.Type: ApplicationFiled: May 14, 2011Publication date: March 14, 2013Applicant: Cu RNA ,Inc.Inventors: Joseph Collard, Olga Khorkova Sherman
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Publication number: 20120190634Abstract: A lipoteichoic acid (LTA)-derived glycolipid, and a pharmaceutical, food or cosmetic composition and a vaccine adjuvant including the same are provided. The LTA-derived glycolipid can inhibit the production of inflammatory cytokines and thus have anti-inflammatory effects. Therefore, the pharmaceutical, food or cosmetic compositions including the LTA-derived glycolipid can be used to prevent and treat inflammatory diseases, and the LTA-derived glycolipid can be also used as the vaccine adjuvant.Type: ApplicationFiled: August 26, 2010Publication date: July 26, 2012Applicant: RNA INC.Inventors: Dae Kyun Chung, Kyoung Soon Jang, Byung Gee Kim, Han Geun Kim, Na Ra Kim, Hea Young Lee, Bong Jun Jung, Tae Rahk Kim, Ji Hye Jeong
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Publication number: 20100028463Abstract: The present invention relates to an extract of Stewartia koreana and use thereof. More particularly, it relates to an extract of Stewartia koreana which is extracted with any one selected from the group consisting of water, a C1-4 low alcohol, a polar solvent, a non-polar solvent and a mixture thereof, and a pharmaceutical composition for promoting angiogenesis or tissue regeneration and a cosmetic for improving wrinkles comprising the same as an effective ingredient. The extract of Stewartia koreana according to the present invention promotes migration and multiplication of endothelial cell and shows excellent effect in angiogenesis and wound healing and thus, is useful in treatment or prevention of diseases which requires angiogenesis for healing of wounded and frostbitten region, wound healing after surgical operation, and treatment and prevention of gastric ulcer, ischaemic heart diseases and hair loss.Type: ApplicationFiled: February 13, 2007Publication date: February 4, 2010Applicant: RNA, INC.Inventors: Ji Young Kim, Dae Kyun Chung, Tae Hoon Lee, Guy Wilhem Lee, Jung Min Lee
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Publication number: 20080241840Abstract: The present invention describes, in certain embodiments, a composition for detecting a tau protein comprising a modified detector molecule having two ends, a first end capable of binding the tau protein and a second end comprising a single-stranded DNA template, wherein the template is capable of being replicated by an RNA polymerase.Type: ApplicationFiled: November 1, 2007Publication date: October 2, 2008Applicant: Q-RNA, Inc.Inventors: Abraham Grossman, James Moe, Sara Vasan, Phyllus Y. Mong
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Publication number: 20060257904Abstract: Described herein are compositions and methods for identifying cellular factors involved in protein agglomeration. One such factor is a nucleic acid component. Another factor is a cellular binding factor. The nucleic acid components, and methods of using them, to interact with agglomeration proteins are also disclosed herein. The nucleic acid compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally or non-naturally occurring molecule with twenty or more ribonucleotide bases. For RNA, at least one nucleotide sequence portion of this RNA molecule has affinity to at least one consensus sequence present in the agglomeration RNA-binding protein. Methods disclosed herein are directed towards detecting the presence of one or more agglomeration proteins in a sample matrix using the amplibody compositions described herein.Type: ApplicationFiled: April 7, 2006Publication date: November 16, 2006Applicant: Q-RNA, Inc.Inventors: Abraham Grossman, James Moe, Sara Vasan, Eliot Davidowitz
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Publication number: 20060212947Abstract: Embodiments of the present invention feature compositions and methods for making an animal and an animal exhibiting characteristics of an agglomeration disease. The method comprises the steps of providing an animal cell and placing a vector in said cell having a non-coding RNA under the control of a promoter and controlling the expression of said non-coding RNA with said promoter.Type: ApplicationFiled: January 10, 2006Publication date: September 21, 2006Applicant: Q-RNA, Inc.Inventors: Abraham Grossman, Michael Evgenev
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Publication number: 20060199194Abstract: The present invention describes, in certain embodiments, a composition for detecting a tau protein comprising a modified detector molecule having two ends, a first end capable of binding the tau protein and a second end comprising a single-stranded DNA template, wherein the template is capable of being replicated by an RNA polymerase.Type: ApplicationFiled: September 28, 2005Publication date: September 7, 2006Applicant: Q-RNA, Inc.Inventors: Abraham Grossman, James Moe, Sara Vasan, Phyllus Mong
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Publication number: 20060141467Abstract: Embodiments of the present invention are directed to methods and kits for the generation of double stranded RNA by RNA dependent RNA polymerases. The methods and kits feature exponential generation of such RNAs through simple steps/ The RNA is suitable for interference with expression in cells.Type: ApplicationFiled: December 18, 2003Publication date: June 29, 2006Applicant: Q-RNA, Inc.Inventor: Brian Zeiler
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Publication number: 20060024736Abstract: Disclosed herein are methods of detecting target molecules from a complex sample using a modified affinity ligand. In particular, the modified affinity ligand is an antibody specific for the target and has conjugated to it a nucleic acid molecule. This conjugated nucleic acid molecule serves as a template for a replicase that can replicate the template a billion-fold in an matter of minutes. The replication products then serve to facilitate a detectable signal indicating the presence of the target in the sample.Type: ApplicationFiled: September 28, 2005Publication date: February 2, 2006Applicant: Q-RNA, Inc.Inventor: Abraham Grossman
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Publication number: 20050272081Abstract: The present invention is directed to methods, compositions, kits and devices for making a nucleic acid having selected affinity to a target molecule. One embodiment of the present invention is a method of making a replicatable nucleic acid template having a selected affinity to a target. The method comprises the step of applying a selection to a first generation comprising at least one replicatable nucleic acid template as the replicatable nucleic acid template is replicated by a nucleic acid polymerase to form at least one subsequent generation comprising a replicatable nucleic acid template. The selection is based on the affinity of the replicatable nucleic template of different generations to the target. The nucleic acid polymerase introduces genetic variability between generations of the replicatable nucleic acid template to produce replicatable nucleic acid templates having different affinities to the target.Type: ApplicationFiled: May 24, 2005Publication date: December 8, 2005Applicant: Q-RNA, Inc.Inventor: Abraham Grossman
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Publication number: 20050214805Abstract: Disclosed herein are methods of detecting target molecules from a complex sample using a modified affinity ligand. In particular, the modified affinity ligand is an antibody specific for the target and has conjugated to it a nucleic acid molecule. This conjugated nucleic acid molecule serves as a template for a replicase that can replicate the template a billion-fold in an matter of minutes. The replication products then serve to facilitate a detectable signal indicating the presence of the target in the sample.Type: ApplicationFiled: November 9, 2004Publication date: September 29, 2005Applicant: Q-RNA, Inc.Inventor: Abraham Grossman
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Patent number: 6916613Abstract: The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have utility in medical diagnosis and analysis of various chemical compounds in specimens and samples, as well as the design of test kits and apparatus for implementing such methods.Type: GrantFiled: April 27, 2001Date of Patent: July 12, 2005Assignee: Q-RNA, Inc.Inventors: Alexander Munishkin, Abraham Grossman
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Publication number: 20030180725Abstract: The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have utility in medical diagnosis and analysis of various chemical compounds in specimens and samples, as well as the design of test kits and apparatus for implementing such methods.Type: ApplicationFiled: April 27, 2001Publication date: September 25, 2003Applicant: Q-RNA, INC.Inventors: Alexander Munishkin, Abraham Grossman
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Publication number: 20030087233Abstract: The present invention is directed to methods, compositions, kits and devices for making a nucleic acid having selected affinity to a target molecule. One embodiment of the present invention is a method of making a replicatable nucleic acid template having a selected affinity to a target. The method comprises the step of applying a selection to a first generation comprising at least one replicatable nucleic acid template as the replicatable nucleic acid template is replicated by a nucleic acid polymerase to form at least one subsequent generation comprising a replicatable nucleic acid template. The selection is based on the affinity of the replicatable nucleic template of different generations to the target. The nucleic acid polymerase introduces genetic variability between generations of the replicatable nucleic acid template to produce replicatable nucleic acid templates having different affinities to the target.Type: ApplicationFiled: December 29, 2000Publication date: May 8, 2003Applicant: Q-RNA, Inc.Inventor: Abraham Grossman