Abstract: The invention involves the use of novel nucleic acid sequences to detect, modulate, ablate, inhibit or augment the transcription and therefore translation and expression of functionally-linked genes. The present disclosure is based on the novel finding that Transposable Element remnant (TEr) RNA or promoter non-processive transcripts (NPtx) have a high probability of aligning with high identity to transcriptional regulatory regions of functionally-linked genes, suggesting that they participate in beneficial transcriptional crosstalk.

Abstract: A computer network with distributed shared memory, including a clustered memory cache aggregated from and comprised of physical memory locations on a plurality of physically distinct computing systems. The network also includes a plurality of local cache managers, each of which are associated with a different portion of the clustered memory cache, and a metadata service operatively coupled with the local cache managers. Also, a plurality of clients are operatively coupled with the metadata service and the local cache managers. In response to a request issuing from any of the clients for a data item present in the clustered memory cache, the metadata service is configured to respond with identification of the local cache manager associated with the portion of the clustered memory cache containing such data item.

Abstract: A computer network with distributed shared memory, including a clustered memory cache aggregated from and comprised of physical memory locations on a plurality of physically distinct computing systems. The clustered memory cache is accessible by a plurality of clients on the computer network and is configured to perform page caching of data items accessed by the clients. The network also includes a policy engine operatively coupled with the clustered memory cache, where the policy engine is configured to control where data items are cached in the clustered memory cache.