Abstract: Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) comprising at least one non-naturally occurring amino acid mutation. In some embodiments, the S protein is derived from an Omicron variant. Additionally provided are relevant polynucleotides, vectors, cells, compositions, kits, production methods and methods of use.
Type:
Application
Filed:
October 31, 2023
Publication date:
May 16, 2024
Applicant:
RNAimmune, Inc.
Inventors:
David BROWN, Yong-sik BONG, Neeti ANANTHASWAMY, Naihsuan C. GUY, Dong SHEN
Abstract: Novel lipids, compositions, and methods of using the novel lipids and compositions are disclosed. Three-component lipid nanoparticle compositions comprising the novel lipids or other types of lipids, and methods of using the three-component lipid nanoparticle compositions are disclosed. Three-component lipid nanoparticle compositions contain a steroidal or structural lipid-containing component, a PEGylated lipid-containing component, a cationic or ionizable lipid-containing component, and are free of phospholipids. Pharmaceutical formulations including the three-component lipid nanoparticle compositions and further including therapeutic and/or prophylactics such as mRNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs.
Type:
Application
Filed:
April 7, 2023
Publication date:
November 9, 2023
Applicant:
RNAimmune, Inc.
Inventors:
Evan Michael Lewoczko, Renxiang Chen, Neeti Ananthaswamy, Dong Shen
Abstract: Compositions and methods are provided for potent mRNA vaccines for prevention and treatment of 2019 novel Coronavirus (2019-nCoV) infections. The compositions include a pharmaceutical composition containing one or more mRNA molecules encoding spike protein epitopes, including mutated epitopes, or mRNA cocktails that encode critical viral genes together with pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Methods for stimulating system immune responses and treatment are provided, including subcutaneous, intraperitoneal and intramuscular injections.
Type:
Application
Filed:
February 8, 2021
Publication date:
April 6, 2023
Applicant:
RNAimmune, Inc.
Inventors:
Shenggao TANG, Dong SHEN, Chun LU, Ziyang HE, Jiaxi HE, Patrick Y. LU