Abstract: It has surprisingly been discovered that it is possible to stabilize biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood. This invention describes methods to stabilize and preserve biomolecules, whole cells, tissues, blood and biological samples using DES mixtures.
Type:
Grant
Filed:
August 14, 2017
Date of Patent:
January 21, 2020
Assignee:
RNASSIST LTD.
Inventors:
Andrew Simon Goldsborough, Malcolm Robert Bates
Abstract: It has surprisingly been discovered that it is possible to stabilize biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood. This invention describes methods to stabilize and preserve biomolecules, whole cells, tissues, blood and biological samples using DES mixtures.
Type:
Grant
Filed:
May 30, 2017
Date of Patent:
August 27, 2019
Assignee:
RNASSIST LTD.
Inventors:
Andrew Simon Goldsborough, Malcolm Robert Bates
Abstract: It has surprisingly been discovered that it is possible to stabilize biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood. This invention describes methods to stabilize and preserve biomolecules, whole cells, tissues, blood and biological samples using DES mixtures.
Type:
Grant
Filed:
February 28, 2014
Date of Patent:
July 4, 2017
Assignee:
RNASSIST LTD.
Inventors:
Andres Simon Goldsborough, Malcolm Robert Bates