Patents Assigned to Robarts Research Institute
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Patent number: 9980994Abstract: Myxoma viruses that are deficient in the activity of a Myxoma virus protein selected from the group consisting of M11L, M063, M 136, M-T4 and M-T7 are useful for treating cancer.Type: GrantFiled: January 21, 2016Date of Patent: May 29, 2018Assignee: ROBARTS RESEARCH INSTITUTEInventors: John W. Barrett, Grant McFadden
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Patent number: 9070190Abstract: A method of registering the position of an object moving in a target volume in an ultrasound imaging system includes capturing a first ultrasound image of a target volume. A second ultrasound image of the target volume is then captured after the capturing of the first ultrasound image. The position of the object in the target volume is identified using differences detected between the first and second ultrasound images. In another aspect, a region of interest in the target volume is determined. A segment of an operational scan range of a transducer of the ultrasound imaging system encompassing the region of interest is determined. The transducer is focused on the segment of the operational scan range during image capture.Type: GrantFiled: September 15, 2011Date of Patent: June 30, 2015Assignee: Robarts Research InstituteInventors: Lori Anne Gardi, Donal B. Downey, Aaron Fenster
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Patent number: 8899125Abstract: A mechanical arm assembly comprises an arm rotatable about a pivot, a first force generating device for maintaining the arm at a datum, and a second force generating device for compensating for the first generating device to maintain the arm in positions other than the datum.Type: GrantFiled: September 26, 2008Date of Patent: December 2, 2014Assignee: Robarts Research InstituteInventors: Jeffrey Bax, Aaron Fenster
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Patent number: 8791084Abstract: A method of treating a pathophysiological condition caused by the production of growth-inhibiting proteoglycans is provided. It is based on the finding that down-regulation of SOX9 results in decreased production of growth-inhibiting factors such as proteoglycans, and increased production of growth-promoting factors such as a laminin and fibronectin. The method of the present invention comprises the inhibition of SOX9 expression and function with an inhibitor such as an antisense oligonucleotide or a siRNA.Type: GrantFiled: October 25, 2007Date of Patent: July 29, 2014Assignee: Robarts Research InstituteInventors: Arthur Brown, Paul Gris
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Patent number: 8788019Abstract: A system and method for performing a biopsy of a target volume and a computing device for planning the same are provided. A three-dimensional ultrasound transducer captures ultrasound volume data from the target volume. A three-dimensional registration module registers the ultrasound volume data with supplementary volume data related to the target volume. A biopsy planning module processes the ultrasound volume data and the supplementary volume data in combination in order to develop a biopsy plan for the target volume. A biopsy needle biopsies the target volume in accordance with the biopsy plan.Type: GrantFiled: February 28, 2006Date of Patent: July 22, 2014Assignee: Robarts Research InstituteInventors: Donal Downey, Aaron Fenster
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Publication number: 20130336930Abstract: Myxoma viruses that are deficient in the activity of a Myxoma virus protein selected from the group consisting of M11L, M063, M 136, M-T4 and M-T7 are useful for treating cancer.Type: ApplicationFiled: August 19, 2013Publication date: December 19, 2013Applicant: ROBARTS RESEARCH INSTITUTEInventors: John W. BARRETT, Grant MCFADDEN
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Patent number: 8512713Abstract: Myxoma viruses that are deficient in the activity of a Myxoma virus protein selected from the group consisting of M11L, M063, M 136, M-T4 and M-T7 are useful for treating cancer.Type: GrantFiled: June 1, 2007Date of Patent: August 20, 2013Assignee: Robarts Research InstituteInventors: John W. Barrett, Grant McFadden
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Publication number: 20130209430Abstract: Methods are provided for increasing stem cells, hematopoietic progenitor/stem cells, mesenchymal progenitor/stem cells, mesodermal progenitor/stem cells, muscle progenitor/stem cells, or neural progenitor/stem cells in vivo in a mammalian subject. Methods are also provided for treating an immune related disease, a mesenchymal/mesoderm degenerative disease, or a neurodegenerative disease in a mammalian subject in need thereof.Type: ApplicationFiled: January 8, 2013Publication date: August 15, 2013Applicants: ROBARTS RESEARCH INSTITUTE, UNIVERSITY OF WASHINGTONInventors: UNIVERSITY OF WASHINGTON, ROBARTS RESEARCH INSTITUTE
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Publication number: 20130171106Abstract: The present invention relates to therapeutic use of a combination of Myxoma virus, including in combination with rapamycin. Treatment with rapamycin enhances the ability of Myxoma virus to selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon. The combination of rapamycin and Myxoma virus can be used to treat diseases characterized by the presence of such cells, including cancer. The invention also relates to therapeutic use of Myxoma virus that does not express functional M135R.Type: ApplicationFiled: November 16, 2012Publication date: July 4, 2013Applicant: ROBARTS RESEARCH INSTITUTEInventor: Robarts Research Institute
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Patent number: 8444543Abstract: An apparatus for determining a distribution of a selected therapy in a target volume is provided. A three-dimensional ultrasound transducer captures volume data from the target volume. A computing device is in communication with the three-dimensional ultrasound transducer for receiving the volume data and determining the distribution of the selected therapy in the target volume along a set of planned needle trajectories using the volume data. At least one of the needle trajectories is oblique to at least one other of the planned needle trajectories.Type: GrantFiled: September 8, 2008Date of Patent: May 21, 2013Assignee: Robarts Research InstituteInventors: Aaron Fenster, Lori Gardi, Donal Downey, Chandima Edirisinghe, Mingyue Ding
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Patent number: 8372397Abstract: Methods are provided for increasing stem cells, hematopoietic progenitor/stem cells, mesenchymal progenitor/stem cells, mesodermal progenitor/stem cells, muscle progenitor/stem cells, or neural progenitor/stem cells in vivo in a mammalian subject. Methods are also provided for treating an immune related disease, a mesenchymal/mesoderm degenerative disease, or a neurodegenerative disease in a mammalian subject in need thereof.Type: GrantFiled: November 30, 2010Date of Patent: February 12, 2013Assignees: University of Washington, Robarts Research InstituteInventors: Randall T. Moon, Mickie Bhatia, Jennifer Jean Trowbridge
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Patent number: 8227440Abstract: The present invention relates to therapeutic use of Myxoma virus. Myxomas virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon and can be used to treat diseases characterized by the presence of such cells, including cancer.Type: GrantFiled: August 28, 2009Date of Patent: July 24, 2012Assignee: Robarts Research InstituteInventors: Grant McFadden, John C. Bell
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Patent number: 8193812Abstract: A surface coil array comprises a surface coil support and an arrangement of non-overlapping magnetically decoupled surface coils mounted on the support. The surface coils encompass a volume into which a target to be imaged is placed. Magnetic decoupling circuits act between adjacent surface coils. Impedance matching circuitry couples the surface coils to conventional transmit and receive components.Type: GrantFiled: June 30, 2010Date of Patent: June 5, 2012Assignee: Robarts Research InstituteInventors: Robert G. Pinkerton, Ravi S. Menon
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Publication number: 20110195050Abstract: The present invention relates to therapeutic use of a combination of Myxoma virus, including in combination with rapamycin. Treatment with rapamycin enhances the ability of Myxoma virus to selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon. The combination of rapamycin and Myxoma virus can be used to treat diseases characterized by the presence of such cells, including cancer. The invention also relates to therapeutic use of Myxoma virus that does not express functional M135R.Type: ApplicationFiled: August 4, 2010Publication date: August 11, 2011Applicant: ROBARTS RESEARCH INSTITUTEInventors: Grant McFadden, John Barrett, Marianne Stanford
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Publication number: 20110163751Abstract: A surface coil array comprises a surface coil support and an arrangement of non-overlapping magnetically decoupled surface coils mounted on the support. The surface coils encompass a volume into which a target to be imaged is placed. Magnetic decoupling circuits act between adjacent surface coils. Impedance matching circuitry couples the surface coils to conventional transmit and receive components.Type: ApplicationFiled: June 30, 2010Publication date: July 7, 2011Applicant: ROBARTS RESEARCH INSTITUTEInventors: Robert G. Pinkerton, Ravi S. Menon
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Publication number: 20110158945Abstract: Myxoma viruses that are deficient in the activity of a Myxoma virus protein selected from the group consisting of M11L, M063, M 136, M-T4 and M-T7 are useful for treating cancer.Type: ApplicationFiled: June 1, 2007Publication date: June 30, 2011Applicant: ROBARTS RESEARCH INSTITUTEInventors: John W. Barrett, Grant McFadden
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Publication number: 20110091448Abstract: Methods are provided for increasing stem cells, hematopoietic progenitor/stem cells, mesenchymal progenitor/stem cells, mesodermal progenitor/stem cells, muscle progenitor/stem cells, or neural progenitor/stem cells in vivo in a mammalian subject. Methods are also provided for treating an immune related disease, a mesenchymal/mesoderm degenerative disease, or a neurodegenerative disease in a mammalian subject in need thereof.Type: ApplicationFiled: November 30, 2010Publication date: April 21, 2011Applicants: UNIVERSITY OF WASHINGTON, ROBARTS RESEARCH INSTITUTEInventors: Randall T. MOON, Mickie BHATIA, Jennifer Jean TROWBRIDGE
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Publication number: 20090234369Abstract: There is provided a guide apparatus for orienting a medical tool relative to and through a remote fulcrum or remote center of motion. The guide apparatus may comprise: at least one crank arm comprising at least a portion of a first hinged coupling for hinged coupling to a stabilizer; at least one link arm comprising at least a portion of a second hinged coupling for hinged coupling to the crank arm at a location spaced from the first hinged coupling; a tool holder for supporting a medical tool on the link arm at a location spaced from the first hinged coupling; wherein the rotational axes of the first and second hinged couplings intersect to define a remote fulcrum. The guide apparatus may be configured to be an open-loop spherical chain or a closed-loop spherical chain.Type: ApplicationFiled: June 19, 2007Publication date: September 17, 2009Applicant: ROBARTS RESEARCH INSTITUTEInventors: Jeffrey Bax, Derek Cool, Lori Gardi, Aaron Fenster
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Patent number: 7582614Abstract: The present invention relates to therapeutic use of Myxoma virus. Myxoma virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon and can be used to treat diseases characterized by the presence of such cells, including cancer.Type: GrantFiled: March 8, 2004Date of Patent: September 1, 2009Assignee: Robarts Research InstituteInventors: Grant McFadden, John C. Bell
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Publication number: 20090198094Abstract: An apparatus for determining a distribution of a selected therapy in a target volume is provided. A three-dimensional ultrasound transducer captures volume data from the target volume. A computing device is in communication with the three-dimensional ultrasound transducer for receiving the volume data and determining the distribution of the selected therapy in the target volume along a set of planned needle trajectories using the volume data. At least one of the needle trajectories is oblique to at least one other of the planned needle trajectories.Type: ApplicationFiled: September 8, 2008Publication date: August 6, 2009Applicant: ROBARTS RESEARCH INSTITUTEInventors: Aaron Fenster, Lori Gardi, Donal Downey, Chandima Edirisinghe, Mingyue Ding