Patents Assigned to Robert L. Letcher
  • Enteric encapsulation of ancrod for oral administration
    Patent number: 4729893
    Abstract: Disclosed is a pharmaceutically effective agent and method of use, comprising ancrod which has been incubated with neuraminidase. The neuraminidase-treated ancrod (NTA) can be substituted for ancrod in ancrod therapy, when immunological resistance to the latter has become manifest. Conversely, NTA can be administered initially, and ancrod substituted therefor after NTA resistance becomes manifest. In a second embodiment, the efficacy of ancrod treatment is improved by enterically coated oral administration of native ancrod.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: March 8, 1988
    Assignee: Robert L. Letcher
    Inventors: Robert L. Letcher, Jeffrey W. Williams
  • Neuraminidase treated ancrod
    Patent number: 4585653
    Abstract: Disclosed is a pharmaceutically effective agent and method of use, comprising ancrod which has been incubated with neuraminidase. The neuraminidase-treated ancrod (NTA) can be substituted for ancrod in ancrod therapy, when immunological resistance to the latter has become manifest. Conversely, NTA can be administered initially, and ancrod substituted therefor after NTA resistance becomes manifest.
    Type: Grant
    Filed: December 26, 1984
    Date of Patent: April 29, 1986
    Assignee: Robert L. Letcher
    Inventor: Jeffrey W. Williams