Abstract: Straight- and branched-chain alkanes and 1-hydroxyalkanes of 4 to 18 carbon atoms, substituted in the .omega.-position by hetero-cyclic groups having the formula: wherein X is a methine group or a nitrogen atom and Y is oxygen or sulfur are prepared by reacting a haloalkane or a haloalkanol with an alkali metal salt of a compound containing the desired heterocyclic group, such as a pyridone or a substituted pyrimidine. The compounds have been found to be useful in accelerating the dark adaptation, as determined in tests with mice.
Abstract: A 2-thio-6-chlorouracil having the formula: ##STR1## wherein R.sub.1, R.sub.3 and R.sub.5 are the same or different and represent an alkyl, aryl or aralkyl group. R.sub.1 can also be hydrogen or an alkenyl group. These compounds are useful as inhibitors of the enzyme, alcohol dehydrogenase.