Abstract: A method to treat cartilage and peri-cartilage is provided which utilizes a pseudoplastic scaffold comprising a PEGylated protein-containing microgel and a hydrolyzed collagen component. The pseudoplastic scaffold composition can be applied topically, via injection, or via ingestion.

Abstract: A method of treating a biological hard tissue that includes applying an antimicrobial composition to a biological hard tissue. The antimicrobial composition includes at least one polymeric biguanide; a vicinal diol component comprising at least one monoalkyl glycol and at least one monoalkyl glycerol, where a weight ratio of the at least one polymeric biguanide and the vicinal diol component ranges from 1:0.05 to 1:500, and a chelating agent, where a weight ratio of the at least one polymeric biguanide and the chelating agent ranges from 1:0.01 to 1:100. The biological hard tissue is selected from bone, cementum, dentin, enamel, keratin, or sclerenchyma.

Abstract: The reduction in the sol-gel temperature of aqueous poloxamer surfactant compositions by the addition of hydrophobic vicinal diols is provided. Lowering of the sol-gel temperature and the gelling efficiency of water-soluble poloxamer block copolymers of polyethylene oxide-b-polypropylene oxide-b-polyethylene oxide has been markedly improved by the addition of small amounts of at least one hydrophobic vicinal diol, such as monoalkyl glycols, monoalkyl glycerols, or monoacyl glycerols. The decrease in the sol-gel temperature facilitates gel formation, and such gels exhibit greater residence time on a surface, particularly those with biological properties.

Abstract: Antimicrobial polymer coating formulations are prepared that protect biological surfaces by treating, reducing, ameliorating, preventing or inhibiting pathogenic microorganism ingress to a human or animal host, reducing the potential for infection, particularly by necrotizing fasciitis originating microorganisms, through use of a polymer coating barrier containing antimicrobial agents that facilitates sustained release of biocidal agents active against such opportunistic microorganisms. Such formulations are effective for inhibiting microbial ingress pertaining to soft tissue and skin tears, abrasions, punctures and surgical wounds, and can be used as in water environments and as a skin protectant sunscreen and insect repellent.

Abstract: This invention relates generally to water-insoluble but water-swellable and deformable crosslinked PEGylated microgel particles of proteins and protein-based macromolecules that are pseudoplastic (shear thinning) and flow in aqueous media under shear and which can be injected or made to flow, wherein said microgel particles can reform as a cluster of microgel particles when shearing forces are removed. The microgel particles function as a matrix to support cell growth, viability, and proliferation.