Abstract: A method, a mobile device and a kit for performing an analytical measurement are disclosed, wherein outliers are eliminated. In the inventive method, a mobile device having a camera and a test strip for performing a color-change detection reaction are provided. A sample is applied to a test field of the test strip and an image of at least part of the test strip is captured. A region of interest in the image is determined and associated with a first sub-set of pixels. A color distribution is evaluated and outliers are eliminated in the first sub-set of pixels. A sub-region of interest is determined within the region of interest and is associated with a second sub-set of pixels. Mean values of the color distributions of the first sub-set of pixels and the second sub-set of pixels are compared to thereby determine homogeneity information of the image.

Abstract: A method for generating a module configured to determine concentration of an analyte in a sample of a body fluid is disclosed. The method includes providing a first set of measurement data derived from images of one or more test strips indicating a color transformation in response to a body fluid containing an analyte. The images can be recorded by multiple devices with differing cameras, software and/or hardware device configurations for image recording and image data processing. A neural network model can be generated in a machine learning process applying an artificial neural network and a module configured to determine concentration of an analyte in a second sample of a body fluid can be generated. Further, the present disclosure includes a system for generating the module as well as a method and a system for determining concentration of an analyte in a sample of a bodily fluid.

Abstract: The present invention relates to a test element for the detection of an analyte comprising an enzyme, wherein the enzyme is incorporated in a nanocapsule.

Abstract: Management of a diabetic condition may be performed by detecting a mealtime and/or an increased level of activity associated with a user. The mealtime is detected based one or more mealtime indicators that may indicate a likelihood of an occurrence of a mealtime. Each mealtime indicator provides additional context around the likelihood of a mealtime. To assist in managing the diabetic condition, a user's elevated activity levels may be detected. The activity level of a user is detected based on one or more activity indicators. Each activity indicator provides additional context around the likelihood of an increased level of activity by the user. Management of the diabetic condition may be performed proximate a mealtime or a user exercising to increase the efficacy of management of the diabetic condition.

Abstract: A lock mechanism for a compartment has been developed. The lock mechanism includes a deformable arm affixed to a housing of the compartment and positioned within the compartment. The deformable arm includes a first end configured to be biased into a first position to engage a latch of a door of the compartment to prevent the latch from opening, and a receiving surface configured to receive an external force to move the deformable arm to a second position that disengages the first end from the latch to enable opening of the latch while the external force is applied to the receiving surface.

Abstract: Systems and methods for automatically displaying patterns in biological data may include one or more processors, and machine readable instructions. The machine readable instructions can cause the one or more processors to divide biological data into segments of interest. The one or more processers can transform, automatically, each of the segments of interest into a set of features according to a mathematical algorithm. Further, the one or more processers can cluster, automatically, the segments of interest into groups of clustered segments according to a clustering algorithm. The segments of interest can be grouped in the groups of clustered segments based at least in part upon the set of features. A cluster center can be associated with one of the groups of clustered segments. Moreover, the one or more processers can present, automatically, the cluster center on a human machine interface.

Abstract: A method of determining analyte concentration in a body fluid with a mobile device having a camera. A user is prompted to apply body fluid to an optical test strip and then waits a predetermined minimum waiting time. The camera captures an image of part of the test field having the body fluid applied thereto. Analyte concentration is determined based on the image captured. The determination includes estimating a point in time of sample application to the test field by taking into account time-dependent information derived from the image captured using a first color channel of a color space. The determination also estimates the concentration of the analyte by taking into account concentration-dependent information derived from the image using a second color channel of the color space.

Abstract: A method for generating graphical data of a patient treatment history includes receiving medical data for the patient corresponding to patient visits to a healthcare provider and generating graphical data corresponding to a timeline view of the patient visits. The generated graphical data include first and second graphical elements corresponding to first and second diagnoses based on the medical data during a current patient visit and a prior patient visit. Each graphical element includes a graphical indicator of a diagnosis for a medical condition and at least one graphical sub-element, the at least one graphical sub-element being relevant to a physiological parameter selected from the medical data and related to the diagnosis. The method includes generating a first graphical connector between the second graphical element and the first graphical element, to indicate a progression of time between patient visits in the timeline view.

Abstract: A method for generating a user interface of predicted disease progressions includes receiving medical data corresponding to patient visits to a healthcare provider, generating a diagnosis for the patient based on the medical data, and generating a predicted diagnosis for a future condition of the patient based upon the diagnosis, and a predictive model. The method further includes generating a timeline view of a diagnosis in the current patient visit and the predicted diagnosis. The graphical element of the diagnosis and the predicted diagnosis both include a graphical indicator of a diagnosis and at least one graphical sub-element of a physiological parameter relevant to the diagnosis. The method further includes generating a graphical connector between the graphical elements to indicate progression of time between a first time of the current patient visit and a second time.

Abstract: Methods and devices involving using a bolus calculator to account for an uncertainty of a carbohydrate estimate to reduce a risk of hypoglycemia and/or a risk of hyperglycemia. More specifically, methods and devices using an algorithm executed by a processor of the bolus calculator and using a carbohydrate estimate and a measure defining the uncertainty of the carbohydrate estimate to determine the probability of hypoglycemia and/or hyperglycemia if the carbohydrate estimate is an overestimate or an underestimate, and subsequently providing recommendations and alerts to a user.

Abstract: An alert is used to inform a user that their blood glucose level has dropped below a threshold (e.g., the user is hypoglycemic) or has increased above a threshold (e.g., the user is hyperglycemic). There is a hierarchy of alerts from lowest priority to highest priority. The alert is communicated by a user device (e.g., a mobile device), which is, for example, a smartphone, smart watch, home automation device, or the like. The alert is modified in order to increase the likelihood that the user receives or acknowledges the alert within a minimal amount of time. An intensity level (e.g., a volume) of an alert is modified based on, for example, whether the user has acknowledged a previous alert. A modality or a sensory channel of an alert is changed if an initial alert does fails to elicit a response from the user.

Abstract: An ambulatory medical device and a method of communication between medical devices are disclosed. In one embodiment, the medical device includes a module for communication with at least a second medical device wherein the module for communication is adapted to be activated by a value of a physiological parameter of an animal. In one embodiment, the method of the present invention involves a first medical device and at least a second medical device wherein the communication between said medical devices is activated by a value of a physiological parameter of an animal.

Abstract: A method for managing refilling a first reservoir of an ambulatory infusion system from a first container that stores a first drug and for managing refilling a second reservoir of the ambulatory infusion system out of a second container that stores a second drug is disclosed. The method includes repeatedly and automatically carrying out a filling volume assessment routine, which involves determining the expected infusion of the first drug and the second drug between the present time tp and the end of an estimation time interval tf and determining if the first reservoir shall be refilled and/or if the second reservoir shall be refilled at tp based on the expected infusion of the first drug and the second drug determined in step (a). Ambulatory infusion device control units and ambulatory infusion devices that are configured for carrying out such method are also disclosed.

Abstract: A cannula cartridge for receiving a cannula includes a needle assembly, a cannula and a protector. The needle assembly is movable within the protector between first and second positions. In the first position the needle is covered by the protector and a retainer of the protector engages an engagement element of the needle hub by a form fit connection. In the second position the needle at least partially extends from the protector. An inserter can move the needle assembly between the first position and to the second position and then back to the first position. The retainer and the engagement element are configured such that a holding force of the retainer is overcome by applying forces parallel to the axis of the needle. An inventive kit that includes an inserter and a driver for moving the needle assembly and a method of manufacturing the cannula cartridge are also disclosed.

Abstract: Management of a diabetic condition may be performed by detecting a mealtime and/or an increased level of activity associated with a user. The mealtime is detected based one or more mealtime indicators that may indicate a likelihood of an occurrence of a mealtime. Each mealtime indicator provides additional context around the likelihood of a mealtime. To assist in managing the diabetic condition, a user's elevated activity levels may be detected. The activity level of a user is detected based on one or more activity indicators. Each activity indicator provides additional context around the likelihood of an increased level of activity by the user. Management of the diabetic condition may be performed proximate a mealtime or a user exercising to increase the efficacy of management of the diabetic condition.

Abstract: An alert is used to inform a user that their blood glucose level has dropped below a threshold (e.g., the user is hypoglycemic) or has increased above a threshold (e.g., the user is hyperglycemic). There is a hierarchy of alerts from lowest priority to highest priority. The alert is communicated by a user device (e.g., a mobile device), which is, for example, a smartphone, smart watch, home automation device, or the like. The alert is modified in order to increase the likelihood that the user receives or acknowledges the alert within a minimal amount of time. An intensity level (e.g., a volume) of an alert is modified based on, for example, whether the user has acknowledged a previous alert. A modality or a sensory channel of an alert is changed if an initial alert does fails to elicit a response from the user.

Abstract: Disclosed herein is a pierceable elastic septum for use in drug reservoirs and infusion sets, the pierceable septum comprising a first surface and a second surface. The first surface and the second surface are positioned opposite to each other. A distance between the first surface and the second surface is not constant over the first surface, and is configured such that if a higher pressure is applied to the first surface as compared to the second surface, a component of a force, which is exerted on the first surface, acts towards an axis (A) which intersects the center of the first surface and the center of the second surface.

Abstract: A method for storing measurement data detected by a sensor and indicative of an analyte in a body fluid sample using a system having a processor and a memory. First and second measurement data indicative of first and second measurement values measured by a sensor, respectively, are provided. A relative measurement value is determined by the processor and is indicative of a value difference between the first and second measurement values. The first measurement value is stored in a first storage area having a first storage size in the memory. The relative measurement value is stored in a second storage area having a second storage size in the memory that is smaller than the first storage size. An indicator is also stored in the memory and is assigned to the relative measurement storage data in the memory and is indicative of a characteristic of the relative measurement storage data.

Abstract: This disclosure is directed to a disposal container system enabling storage of used or contaminated articles having a generally flat, strip-shaped configuration, such as diagnostic biosensors. The disposal container is removably mountable to a supply container, and has an insertion portion provided in a wall of the disposal container. The insertion portion has a contour configured externally to guide deposit of a flat, strip-shaped article through a narrow slit, the contour further configured internally to deflect any loose articles in the interior space of the disposal container away from any accidental alignment with the slit which would cause free extraction of the articles. The disposal container may be configured for engagement with a supply container, such as a round or non-round vial, in a bottom-cap configuration or in a side-by-side configuration, by way of an engagement portion.

Abstract: A method for detecting an analyte in a sample is disclosed. The method includes providing a mobile device having a camera and an illumination source. A test strip having a test field with at least one test chemical for performing an optical detection reaction in the presence of the analyte is provided. The sample is applied to the test field. Several images of a region of the test strip are captured. The region includes at least part of the test field to which sample is applied. The images are captured before and after the sample is applied and with the illumination source turned on and off. The images captured are compared and differences in light intensities are determined. Analyte concentration is determined using the images captured and the determined light intensities.