Abstract: The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.

Abstract: A method for checking a validity of a mass axis calibration of a mass spectrometer (MS) of an analyzer system, comprising obtaining a mass axis check sample spanning a predetermined m/z measurement range of the MS and automatically processing the sample, performing multiple full scan mode MS measurements of different types using the MS for the at least two mass axis points to obtain measurement data, wherein the different types include at least a first full scan MS measurement in a positive mode and a second measurement in a negative mode, or at least a first full scan measurement for a first mass filter and a second full scan measurement for a second mass filter; comparing the measurement data for each of the at least two mass axis points with respective reference data and determining if a condition is out of specification based on a result of the comparing steps.

Abstract: A centering unit for diagnostics laboratory transporting compartment is presented. The centering unit for diagnostics laboratory transporting compartment comprises at least two arms with grippers for centering diagnostics laboratory transporting compartments of different diameters. For accurate and reliable centering of laboratory transporting compartments, the two arms are biased with a single elastic member. A laboratory system and a method for centering diagnostics laboratory transporting compartment and diagnostics laboratory transporting compartment holder are also disclosed.

Abstract: A healthcare data system. The system comprises a data protection entity configured to: sign at least a portion of a routing header of a data packet with a private key held by the data protection entity, the data packet including a payload and a routing header, the payload including healthcare data and the routing header indicating an intended consumer of the data packet; and transmit the data packet on towards the intended consumer. The healthcare data system further comprises one or more data receivers, each configured to: receive the data packet; and verify the signed routing header.

Abstract: The present invention relates to a method for determining the total amount and/or concentration of an analyte in the presence of a binding molecule as well as kits, compositions and uses relating thereto.

Abstract: Systems for analyzing a biological sample include a separation unit configured to separate a component from the biological sample, an ionization unit configured to generate a plurality of ions from the component, an adjustable mass-selective filtering element, a detector configured to detect ions that pass through the mass-selective filtering element, and a controller connected to the mass-selective filtering element and to the detector, where the controller is configured so that during operation of the system, the controller adjusts the mass-selective filtering element and activates the detector to measure at least three different ion signals corresponding to the plurality of ions, and determines a mass axis shift of the system based on the at least three different ion signals.

Abstract: A method for determining a vertical position of a horizontally extending interface between first and second components is presented. The first and second components are contained in a laboratory sample container in layers vertically separated from each other. The method comprises generating first data, generating second data in the form of picture data of the laboratory sample container containing the first and second components, determining a first probability distribution function in response to the first data, determining a second probability distribution function in response to the second data, and determining the vertical position of the horizontally extending interface depending on the first and second probability distribution functions. The first data depend on the vertical position of the horizontally extending interface. The first and second probability distribution functions assign a probability of the presence of the horizontally extending interface to a vertical position.

Abstract: An optical system configured for Fourier Ptychography is disclosed, comprising at least one array of light emitters, wherein each light emitter is configured for emitting at least one illumination light beam towards a sample plane; at least one lenslet array comprising a plurality of lenses, wherein each of the lenses is dedicated to at least one of the light emitters of the array of light emitters, wherein orientation and shape of the respective lens is adapted to the dedicated light emitter, wherein the lenslet array is configured for focusing the illumination light beams in the sample plane. The array of light emitters and the lenslet array are arranged such that the sample plane is illuminated by the illumination light beams under different illumination angles.

Abstract: A computer-implemented method of automatically managing calibration of an in-vitro diagnostic system is provided comprising determining a lot calibration time period in which a lot calibration is applicable to reagent containers of the same lot, having a predefined time length starting from the time when the lot calibration becomes available, upon making a reagent container of the lot available to the system, determining whether a lot calibration that has not exceeded the lot calibration time period is available and linking the reagent container to the available lot calibration or most recent available lot calibration if more than one lot calibration is available, wherein if a new lot calibration for the same lot becomes available the method comprises replacing the existing link to the previous lot calibration with a link to the new lot calibration.

Abstract: The invention relates to a transport device for a laboratory sample distribution system, the transport device comprising a top cover having a transport surface, the transport surface being adapted to carry sample container carriers, an electromagnetic actuation assembly, the electromagnetic actuation assembly being adapted to generate a magnetic field at the transport surface for magnetic drive-interaction with a sample container carrier placed thereon, a support structure for carrying the actuation assembly, a sensor board being arranged in between the support structure and the top cover, the sensor board being adapted to detect a position of a sample container carrier placed on the transport surface with respect to the transport device, and elastic elements which are biased in between the sensor board and the support structure so that the sensor board is held flush against an inside surface of the top cover by a biasing force resulting from the biasing of the elastic elements.

Abstract: A computer-implemented method for optimising an assignment of one or more medical samples to one or more analytical tests to be conducted on those medical samples. The method comprises the steps of: obtaining an initial assignment of the one or more medical samples to the one or more analytical tests; determining a compliance status for the or each medical sample, the compliance status indicating: (i) whether a sample quality metric of the or each medical sample violates an analytical test specification of the medical sample's assigned analytical test(s) in the initial assignment and/or (ii) whether the or each medical sample is unprocessable; and performing a mitigation action if one or more compliance status indicate: (i) that the sample quality metric of a given medical sample violates the analytical test specification and/or (ii) a given medical sample is unprocessable.

Abstract: The invention relates to an adjustable adapter for closing a c-shaped gap in between two modules of a laboratory system, the adjustable adapter comprising a base extending along a width direction (W) of the adjustable adapter, and a pair of legs each protruding from the base in a length direction (L) of the adjustable adapter so that the base and the legs are arranged in a c-shape of the adjustable adapter, the base being adjustable to set its dimension (D, D1, D2) along the length direction (L).

Abstract: A liquid chromatographic (LC) system is herein disclosed, the LC system comprising at least one fluidic stream comprising at least one HPLC column, a downstream valve connected to the at least one fluidic stream and connectable to a detector via a valve-to-detector conduit, wherein the at least one fluidic stream is connectable to the valve-to-detector conduit via the downstream valve, and where the LC system further comprises a downstream pump fluidically connected to the downstream valve and connectable to the at least one fluidic stream via the downstream valve in order to backflush and thereby clean the at least one HPLC column. A respective automated LC method is herein also disclosed.

Abstract: A method of monitoring a state of a liquid chromatography (LC) stream of an automated analyzer is provided including automatically monitoring a system pressure of an injection assembly of the liquid chromatography stream to generate a time series of system pressures, classifying the time series in one of two or more predetermined classes indicating different states of the LC stream and triggering a response based on the classification result.

Abstract: A method of determining the concentration of an analyte comprising: providing a sensor device comprising: a field effect transistor having a source electrode, a drain electrode and a gate electrode, a sensing electrode electrically connected or integrated into the gate electrode, and a control device for applying operation parameters to the field effect transistor and for monitoring a signal value with the field effect transistor; selecting a set of operation parameters of the field effect transistor, the selecting comprising performing evaluation measurements with the field effect transistor using various sets of operation parameter candidates and selecting a set in accordance with optimization criterion monitored during the evaluation measurements; and detecting the concentration by applying the selected set of operation parameters to the field effect transistor and determining a signal value with the field effect transistor.

Abstract: A laboratory apparatus comprising a housing, wherein the housing comprises a through-opening, wherein the through-opening is adapted for passing through it a transport device for transporting laboratory sample containers in and/or out of the housing, and a cover, wherein the cover comprises at least two ring segments, wherein the ring segments are adjustable to each other between a distant adjustment with at least one distance in between ends of the ring segments for arranging them around the passed through transport device and a near adjustment with less or no distance in between the ends of the ring segments for surrounding the passed through transport device, and wherein the cover in the near adjustment is adapted to cover a part of the through-opening left free by the passed through transport device, wherein the laboratory apparatus is a pre-analytical, analytical, and/or post-analytical laboratory apparatus, in particular a sorting module.

Abstract: A system for securely storing data, such as sensitive personal data, including an interface configured with a REST API, an authentication module, at least one target database for storing the data, and a data access module which is configured to receive requests from a client computer by means of the interface, query data from the at least one target database in response to the received request, determine whether the client computer and/or the user has permission to query, and generate a response data set to respond to the request and transmit it to the client computer, wherein at least some data of the response data set is anonymised if restricted authentication is determined.

Abstract: The invention relates to a chute arrangement for a cap-removal apparatus, the cap removal apparatus being configured to remove caps from sample containers, the chute arrangement comprising a chute for transporting removed caps through a transport space of the chute arrangement, a sensor for detecting caps passing through a detection range of the sensor, the transport space being partially delimited by a chute bottom of the chute, the chute bottom being inclined with respect to gravity, the detection range protruding into the transport space, the detection range having a range border within the transport space, and the range border facing the chute bottom at a distance so that a bypass portion of the transport space is formed in between the chute bottom and the detection range.

Abstract: Methods for identifying a patient who is eligible for an intensification of heart failure therapy are disclosed. Furthermore, methods for optimizing B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy are disclosed. The methods are based on the measurement of the level of at least one marker in a sample from a patient who has heart failure and who receives B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy. Further described are kits and devices adapted to carry out the described methods.