Patents Assigned to Roche Diagnostic Operations, Inc.
  • Publication number: 20220018868
    Abstract: A laboratory sample distribution system comprising a plurality of sample container carriers, each adapted to carry one or more sample containers, each carrier comprising at least one magnetically active device and at least one electrically conductive member, a transport plane adapted to support the carriers, a plurality of electro-magnetic actuators stationary arranged below the transport plane, the actuators being adapted to move the carriers on top of the transport plane by applying a magnetic force to the carriers, a plurality of inductive sensors distributed over the transport plane, a control unit configured to control the movement of the carriers using an output signal provided by the inductive sensors by driving the actuators such that the carriers move along corresponding transport paths, and an evaluation unit configured to linearize the output signal from an inductive sensor by means of a linearization algorithm.
    Type: Application
    Filed: July 14, 2021
    Publication date: January 20, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Pankaj Tanotra, Michele Andruszkiewicz
  • Publication number: 20220020489
    Abstract: A computer-implemented method for inferring a condition of at least one analytical device based on at least one automatic notification received over a network from the analytical device is disclosed. The method comprises receiving, at a data processing agent, at least one automatic notification from at least one analytical device, processing, at the data processing agent, the at least one automatic notification, to thus identify one or more characteristics of the at least one automatic notification from the at least one analytical device, inferring, at the data processing agent, the condition of the at least one analytical device, by applying the one or more identified characteristics to a model; and generating, at the data processing agent, a notification reporting the inferred condition of the analytical device.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 20, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stephen Martin, Jakub Winiarz, Alexandra Paun
  • Patent number: 11226348
    Abstract: A storage module for a laboratory automation system, a method of operating a laboratory automation system, and a laboratory automation system are presented. Items used by laboratory stations are stored centrally in a storage module and can be transported to the laboratory stations using a laboratory sample distribution system.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: January 18, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Urs Vollenweider, Gottlieb Schacher, Goran Savatic, Marco Maetzler, Christoph Ludwig, Christian Loewenstein, Yves Laloux, Rik Harbers, Matthias Edelmann, Andreas Drechsler
  • Publication number: 20220009110
    Abstract: A gripper for a laboratory container sorting device includes a vacuum gripper and a mechanical gripper. The vacuum gripper includes a suction cup and is configured to move the suction cup between a pickup position and a transfer position. The suction cup is configured to pick up a laboratory container when the suction cup is in the pickup position and to transfer the laboratory container when the suction cup is in the transfer position. The mechanical gripper is configured to grip and release the laboratory container when the suction cup is in the transfer position. A laboratory container sorting device, a laboratory system, and a method of operating the laboratory system are also disclosed.
    Type: Application
    Filed: June 25, 2021
    Publication date: January 13, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Norbert Schmitt
  • Publication number: 20220003788
    Abstract: A method of determining a level of interference with a photometric in-vitro diagnostic assay and an in-vitro diagnostic analyzer for carrying out the method are described. The method comprises treating an aliquot of a sample with at least one reagent to obtain a sample/reagent mixture and subjecting the sample/reagent mixture to a photometric measurement in order to obtain a result of the in-vitro diagnostic assay, and during the same photometric measurement determining a preliminary level of interference by semi-quantitatively determining one or more interfering substances in the same sample/reaction mixture. The method further comprises triggering a separate photometric measurement of another aliquot of the same sample either undiluted or diluted with a liquid other than a reagent in order to determine an effective level of interference by quantitatively determining the one or more interfering substances, only upon determining a preliminary level of interference above a predetermined threshold.
    Type: Application
    Filed: June 22, 2021
    Publication date: January 6, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Jean-Pierre Bolliger, Rik Harbers, Rolf Knobel
  • Publication number: 20220006746
    Abstract: A computer implemented method and associated apparatus, networked system, computer readable medium, and computer program element are presented. The computer-implemented method generates a message filter configuration based on a message priority indication received from a first analyzer network. The first analyzer network comprises at least one analytical device configured to generate a message. The method comprises receiving, at a data processing agent, a message priority indication indicating a priority assigned to the message in the first analyzer network, providing, at the data processing agent, at least one message filter configuration based on the message priority indication of the message, and communicating the message filter configuration, or a portion thereof, to a second analyzer network comprising a second analytical device.
    Type: Application
    Filed: June 28, 2021
    Publication date: January 6, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stephen Martin, Alexandra Paun, Jakub Winiarz
  • Patent number: 11215577
    Abstract: A test system for analyzing a sample of a bodily fluid is provided and comprises: at least one test strip comprising at least one capillary channel comprising an inlet opening configured to receive the sample; a vent opening configured to provide an air vent to the capillary channel; and at least one zone consisting of a detection zone and a reagent zone; at least one measuring device configured for interacting with the test strip, the measuring device comprising at least one sealing element for hermetically sealing the vent opening from an ambient atmosphere; and at least one suction device adapted to provide an underpressure to the vent opening; wherein the measuring device further comprises at least one valve or is connectable to the valve, wherein the valve is configured to vent the vent opening of the test strip when the measuring device interacts with the test strip.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: January 4, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Uwe Goebbert, Eloísa Lopez-Calle, Michael Marquant, Christine Nortmeyer, Katja Reiter, Reiner Stein
  • Patent number: 11215627
    Abstract: In conventional automatic analyzers, there have been instances where, when a plurality of associated items are analyzed as a set item, there is high variation in the analysis data obtained using the set item, leading to a need for improvement of analysis precision. The present invention comprises performing, in mutual association, a set of preparation steps to carry out until it is time to analyze an unknown sample, the set of preparation steps including a pre-preparation step in which stirring, etc., is performed when an analysis reagent kit is mounted on the analyzer, and a step for correcting a standard curve in which correction samples that correspond to analysis items are used. This makes it possible to perform analysis after the preparation states of a plurality of analysis reagent kits are collected as needed, enabling high-precision analysis of a set item.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: January 4, 2022
    Assignees: HITACHI HIGH-TECH CORPORATION, ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Kenta Imai, Toshiharu Suzuki, Shigeki Matsubara, Takayuki Sugime, Shunsuke Sasaki, Elke Faatz, Beatus Ofenloch-Haehnle
  • Publication number: 20210402394
    Abstract: A sample concentrating unit and a sample concentrating method are described, which enable fast, precise and reproducible analyte concentration in a sample by evaporation of sample solvent. A specifically directed gas stream in cooperation with a vacuum generated in the sample concentrating unit keeps the sample at boiling point during the entire evaporation procedure while reducing analyte loss and risk of cross-contamination. The fully automated sample concentrating unit is designed to be integrated into an in-vitro diagnostic analyzer.
    Type: Application
    Filed: June 18, 2021
    Publication date: December 30, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Adrian Sievers-Engler
  • Patent number: 11211152
    Abstract: A system and method for managing information relating to requests for a number of tests to be made of at least one sample within a laboratory environment are disclosed. The system may include a sample reception unit, a pre-analytical unit to scan, sort and/or aliquot the sample on request according to respective test requirements included within a respective sample order, an analytical unit to run at least one test on a sorted and/or aliquoted sample, and at least one decision unit. The decision unit acts as a connecting component for interconnecting the sample reception unit, the pre-analytical unit and the analytical unit as both an intermediary and coordinator such that tests can be performed via a recursive workflow until the sample is completely measured. The decision unit is further configured to collate the test results appropriately with the sample and to give a respective report towards a host component.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: December 28, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Ralf Bauer, Werner Schönenberger, Roger Iten
  • Publication number: 20210396775
    Abstract: A laboratory sample distribution system with a number of sample container carriers, each comprising at least one magnetically active device and adapted to carry a sample container; a transport plane adapted to support the carriers; a number of electro-magnetic actuators stationary arranged below the transport plane and adapted to move a corresponding carrier located on top of the transport plane by applying a magnetic force to the carrier; a touch panel arranged below the transport plane adapted to generate position signals (PS) depending on positions of the carriers located on top of the transport plane; a position determination unit adapted to determine the positions of the carriers located on top of the transport plane in response to the position signals (PS); and a control unit adapted to control the operation of the laboratory sample distribution system in response to the determined positions of the carriers.
    Type: Application
    Filed: June 3, 2021
    Publication date: December 23, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Norbert Schmitt
  • Patent number: 11204361
    Abstract: A laboratory automation system for processing sample containers containing laboratory samples and/or for processing the samples is presented. The laboratory automation system comprises a digital camera configured to take an image of the sample container together with a calibration element. The image comprises image data related to the sample container and image data related to the calibration element. The laboratory automation system also comprises an image processing device configured to determine geometrical properties of the sample container depending on the image data related to the sample container and the image data related to the calibration element.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: December 21, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Armin Birrer, Andreas Drechsler, Rik Harbers
  • Patent number: 11204360
    Abstract: A switch for a conveying line for transporting a laboratory diagnostic vessel carrier is presented. The conveying line comprises a first line portion and a second line portion. The switch comprises a curved first guiding surface and a second guiding surface. The switch is moveable between a first position, in which the laboratory diagnostic vessel carrier is transportable along the curved first guiding surface from the first line portion to the second line portion, and a second position, in which the laboratory diagnostic vessel carrier is further transportable along the second guiding surface on the first line portion. A switch assembly and a conveying line are also disclosed.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: December 21, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: David Huber, Daniel Arnold
  • Publication number: 20210387360
    Abstract: A gripping system is provided comprising: gripping fingers of a first type, gripping fingers of a second type, a gripping device for handling sample containers, wherein the gripping device comprises base portions, wherein a gripping finger of the first type and a gripping finger of the second type are releasably fixable to the base portions, and a drive, wherein the drive is adapted to move at least one of the base portions relative to the other base portions to cause a gripping or a releasing of a sample container, and a gripping finger change device, wherein the gripping finger change device is adapted to store gripping fingers of the first type and gripping fingers of the second type, and wherein the gripping finger change device is adapted to replace a gripping finger of the first type fixed to a base portion by a gripping finger of the second type.
    Type: Application
    Filed: May 27, 2021
    Publication date: December 16, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Marius Kraetschmer, Andreas Decool
  • Patent number: 11200326
    Abstract: A method for saving and/or restoring settings of an instrument for processing a sample or reagent is disclosed. The instrument comprises a control unit and an operating system. A storage medium is provided to the instrument. The storage medium comprises a script. The script restores data for restoring settings of the instrument. The script is encrypted and/or digitally signed. The method verifies an identity and/or integrity of the script and executes the script upon starting the instrument by the operating system with the storage medium when the identity and/or integrity of the script correspond to an identity and/or integrity of the instrument. The control unit provides an input menu for allowing a user to input a saving and/or restoring command. The instrument saves settings on the storage medium and/or restores settings of the instrument from the storage medium by the restoring data corresponding to the saving and/or restoring command.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: December 14, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Richard Edward Salin
  • Publication number: 20210373042
    Abstract: A module for an automated laboratory system is disclosed. The module comprises a module connector configured to releasably connect to a component of the automated laboratory system, a detector at least configured to detect at least one component marker located at the component so as to obtain position data of the module indicating an actual position of the module, a processor configured to calculate a position deviation of the module from a target position defined by the component based on the position data and to calculate position alignment data based on the position deviation, and a alignment device configured to align the module to the target position based on the position alignment data. Further, an automated laboratory system and a method for aligning a module are disclosed.
    Type: Application
    Filed: May 24, 2021
    Publication date: December 2, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Ivan Heinzer
  • Patent number: 11187709
    Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: November 30, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Sascha Antoni, Christian Vogl
  • Publication number: 20210364540
    Abstract: A laboratory sample container carrier cleaning apparatus is provided comprising a revolving device, being adapted to move a sample container carrier supplied to the revolving device along a circular path, and a cleaning device, being adapted to clean the sample container carrier being moved along the circular path.
    Type: Application
    Filed: May 11, 2021
    Publication date: November 25, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Christopher William Bates
  • Publication number: 20210364283
    Abstract: An apparatus for measuring an angle between a longitudinal axis of a sample container inserted into an opening of a sample container carrier and a reference ray, the apparatus comprising a first accelerometer being fixable to the sample container and being adapted to generate a number of first accelerometer signals being dependent on the orientation of the sample container, and a calculation unit being coupled to the first accelerometer and being adapted to calculate the angle depending on the number of first accelerometer signals.
    Type: Application
    Filed: May 12, 2021
    Publication date: November 25, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Richard-Paul Daisley
  • Patent number: 11175301
    Abstract: An automatic analyzer includes: a reagent mounting unit 103 in which a plurality of reagent bottles 10 are installed when a reagent bottle 10 is loaded into the automatic analyzer; a reagent conveying mechanism 101 including a gripper mechanism 106; and a reagent mounting mechanism 102 for moving the reagent mounting unit 103 between an installation position at which an operator installs the reagent bottle 10 in the reagent mounting unit 103 and a position at which the gripper mechanism 106 grips the reagent bottle 10. It is thereby possible to achieve saving of a mechanism installation space and reduction of the number of constituent components, automatically carry out an operation from opening of the reagent bottle to loading of the reagent bottle into the reagent disk, and alleviate an operator's burden.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: November 16, 2021
    Assignees: HITACHI HIGH-TECH CORPORATION, ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Takamichi Mori, Kouhei Nonaka, Masaki Hara, Masato Ishizawa, Hitoshi Tokieda, Stephan Sattler